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DANIEL TSUN-YEE CHIU

 
 

Daniel Tsun-Yee Chiu

Highest Degree

Ph. D. in Biochemistry Univ. of 

Calif at Davis

Areas of Specialty

Clinical Hematology, Wellnest Testing, Free Radical Biomedicine

Office Phone

5097/3505

Lab phone

3708

Research website:

Redox Biology and Redoxomics Research Lab

E-mail

dtychiu@mail.cgu.edu.tw

Lab & Research Interest

A.    The Effect of Oxidative Stress on Cellular Function and Human Health

Free radicals like superoxide and nitric oxide are essential for maintaining physiological functions such as phagocytosis, signal transduction and gene regulation. On the other hand, free radicals are also risk factors of ageing (including apoptosis) and degenerative diseases (including cancer, cardiovascular disease, immunosuppresion, brain dysfunction and cataract). Hence, our laboratory employs  G6PD deficient model to investigate how does oxidative stress modulate cellular structure and function. Furthermore, we will address the clinical question whether G6PD-deficient patients are more susceptible to degenerative diseases than normal individuals.

Specific Topics:

 1. The effect of oxidative stress on cellular function (G6PD-deficient cell as model system)

Apply RNAi technique to establish G6PD-deficient cell lines and couple with advanced system biology technology (Proteomics and Metabolomics) for analysis of the comprehensive effect of oxidative stress on cellular physiology.

 2. Development of Antioxidants

     To screen effective antioxidants from herbal medicine.

B.    Research on Hematology

      Research on hematological disorders (including thalassemia and G6PD deficiency) from genomics and proteomics perspectives.

C.   Establish Reference Laboratories

     Reference laboratory to assess oxidative stress and antioxidant capacity.

      Develop ultra-sensitive assays such as Coularray coupled with Metabolomics and Bioinformatics to evaluate the level of oxidative stress and assess the role of oxidative stress in degenerative diseases.

Publication

Publication(since 2014)

  1. Ho HY, Cheng ML, Chiu DTY*(2014)Glucose-6-Phosphate Dehydrogenase - Beyond the Realm of Red Cell Biology.  Free Radical Res. 48:1028-48 (SCI)

  2. Chiu DTY (2014) Oxidative stress in biology and medicine (Editorial Note).  Biomedical J. 37:97-8.

  3. Chiu DTY, Wei YH (2014) Special issue on “Oxidative stress and mitochondrial alterations in ageing and disease. (Editorial).  Free Radical Res. 48: 967-9. (SCI)

  4. Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML*Chiu DTY* (2015) Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance.  Antioxid Redox Sign. 22: 744-59. (SCI)

  5. Yang HC, Cheng ML, Hua YS, Wu YH, Lin HR, Liu HY, Ho HY and Chiu DTY*(2015)Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-kB signaling pathway. J Inflamm-Lond. 12:34. (SCI)

  6. YH Wu, Chiu DTY+, Lin HR, Tang HY, Cheng ML, Ho HY*(2015) Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses-Basel. 7: 6689-706. (SCI)

  7. Chiu DTY (2016) Helmut Sies: A continuous presence in my scientific development. Arch Biochem Biophys. 595: 181-4.(SCI)  

  8. Lin HR, Wu YH, Yen WC, Yang CM*Chiu DTY*(2016) Diminished COX-2/PGE2-mediated antiviral response due to impaired NOX/MAPK signaling in G6PD-knockdown lung epithelial cells. PLoS One. 11:e015346. (SCI)

  9. Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, ……., Lin SY, Chiu DTY, Lin SC* (2016)ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Mol Cell. 62:359-70. (SCI )

  10. Yang HC, Wu YH, Liu HY, Stern A, Chiu DTY* (2016)What has passed is prologue: New cellular and physiological roles of G6PD.  Free Radical Res. 50:1047-64. (SCI)

  11. Chen TL, Yang HC, Hung CY, Ou MH, Pan YY, Cheng ML, Stern Arnold, Lo SJ* and Chiu DTY*(2017)Impaired embryonic development in glucose 6-phosphate dehydrogenase deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death Dis. 8:e2545 (SCI)

  12. Wu YH, Lin HR, Lee YH, Huang PH, Wei HC, Stern A, Chiu DTY(2017)A novel fine tuning scheme of miR-200c in modulating lung cell redox homeostasis. Free Radical Res. 51:591-603(SCI)

  13. Tang HY, Chiu DTY, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC, Cheng ML, Chen CM(2017) Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome. Scientific Reports. 7:8140

  14. Yang HC*, Hung CY, Pan YY, Lo SJ and Chiu DTY(2017) Lipidomic Analysis of Caenorhabditis elegans Embryos.  Bio Protoc. 7 (20).

  15. Wu YH, Lee YH, Shih HY, Chen SH, Cheng YC*Chiu DTY*(2018)Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death Dis. 9:10. (SCI )

  16. Chou CA, Lin CN, Chiu DTY, Chen IW, Chen ST* (2018)Tryptophan as a surrogate prognostic marker for diabetic nephropathy. J Diabetes Invest. 9:366-74. (SCI)