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賴信志教授

  (Hsin-Chih Lai)

學歷

英國劍橋大學病理系所博士

 

 

任課科目

大學部(臨床微生物學及實驗、生物化學)、碩士班(生物技術學)、博士班(高等細菌學)

研究專長

腸道微生物體與宿主免疫力及疾病互動機轉(Deciphering the Interplay between Gut Microbiome and Host Immunity and Diseases)

開發具免疫調控與發炎疾病控制的草藥生物製劑

(Discovery of Novel Bioactive Components from Traditional Chinese Herbs to Treat Inflammatory Diseases)

開發具免疫調控的益生菌與益菌元

(Discovery of Novel Probiotics and Prebiotics with Immunomodulatory Function)

生物感測器開發(Biosensors development)

辦公室分機

3585

實驗室分機

3585

個人網頁

感染、發炎暨分子免疫研究室

E-mail

hclai@mail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

Deciphering the Interplay between Gut Microbiome and Host Immunity and DiseasesGut microbiome has been closely linked to immune development and inflammatory disease progression in local gastrointestinal (GI) tract and systemic extra-GI regions. We mainly focus on several diseases, including gastrointestinal tract diseases (intestinal bowel disorders (IBDs) and colorectal cancer (CRC)), metabolic disorders (obesity and non-alcoholic fatty liver diseases (NAFLD)), and respiratory tract diseases (asthma and mycobacterial infection). Using established murine diseases model (SPF and Germ-free model) and metagenomics microbiota analysis, we aim to uncover the novel players from the microbial and host side in order to develop novel gut microbiota-targeting intervention strategy.


Discovery of Novel Bioactive Components from Medicinal Herbs to Treat Inflammatory Diseases(
開發具免疫調控與發炎疾病控制的草藥生物製劑)Traditional Chinese herbal medicine, including medicinal mushrooms and plants, exerts immune-homeostatic ability of Yin-Yang effects and gut microbiota targeting ability. Based on our established in vitro screening platform and in vivo disease mouse model, we aim to uncover novel bioactive ingredients from medicinal mushrooms and herbs to counteract inflammatory diseases, including IBDs, CRC, obesity, NAFLD, and asthma.

 
Discovery of Novel Probiotics and Prebiotics with Immunomodulatory Function(
開發具免疫調控的益生菌與益菌元)Understanding the interplay between gut microbiota-host immunity in health and disease circumstances will facilitate the discovery of novel gut microbes and derived components in order to develop potential probiotics. Additionally, medicinal herbs-mediated microbiota manipulation will be beneficial for development of novel prebiotics to exploit gut microbiota against inflammatory diseases.

Biosensors development(生物感測器開發)Labor-intensive and time-consuming procedures of clinical diagnosis of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterium (NTM) have been a problem for clinicians to make a proper treatment for patients suffering from these troublesome mycobacterial infections. In collaboration with engineers in academic and bioindustry, we aim to develop fast, simple, and accurate engineered biosensors for diagnosis of MTB and NTM in order to apply to clinical diagnosis. 

專利

專利名稱

國別

專利號碼

發明人

專利權人

專利期間

靈芝多醣體用於抑制脂肪肝形成之用途及其製備方法

中華民國

I569803

柯雲飛、馬 奕安、廖建清、張義德、簡瑋廷、林美鳳、楊嘉蓁、邱振堯、張志榮、林詮盛、吳宗儒、陸嘉真、歐大衛、賴信志、楊定一

長庚生物科技股份有限公司

20170211-

20350726

靈芝多醣體作為抑制肥胖之用途及其製備方式

中華民國

I543765

柯雲飛、馬 奕安、廖建清、張義德、簡瑋廷、林美鳳、楊嘉蓁、邱振堯、張志榮、林詮盛、吳宗儒、陸嘉真、歐 大衛、賴信志、楊定一

長庚生物科技股份有限公司

20160801- 20350524

靈芝多醣體用於促進胰島素敏感性之用途及其製備分法

中華民國

I542355

柯雲飛、馬 奕安、廖建清、張義德、簡瑋廷、林美鳳、楊嘉蓁、邱振堯、張志榮、林詮盛、吳宗儒、陸嘉真、歐 大衛、賴信志、楊定一

長庚生物科技股份有限公司

20160721- 20350604

從牛樟菇中分離的化合物、其製備方法及用途

中華民國

I538671

柯雲飛、馬 奕安、廖建清、簡瑋廷、張義德、邱振堯、呂彥禮、吳宗儒、黃宗騰、陸嘉真、歐大衛、賴信志、楊定一

長庚生物科技股份有限公司

20160621- 20340713

檢測結核性肋膜炎的裝置

中華人民共和國

CN 4756153

王振源、賴信志、樹金忠

王振源

2015-2025

使用Serratia marcescens 突變菌株檢測環境汙染物質之方法及包含發光基因之Serratia marcescensr菌株

中華民國

I352119

賴信志

成功大學

20111111-20241213

基因重組載體、基因重組發光菌及其用於檢測生物抑制性物質之方法

中華民國

I325892

楊琇瑩、賴信志、魏君容、林慧玲

成功大學

20100611- 20231218

檢測裝置

中華民國

M374057

賴信志、王振源、薛博仁、蘇伯琦、洪育芝、張凱誌、陸嘉真

生策會

20100211- 20190915

技術移轉

技術名稱

專利名稱

授權單位

被授權單位

合約期間

肺結核檢測裝置

檢測裝置

生策會

肽湛生技

103/4-113/4

論文與著作(Publication)

 近年所發表論文

  1. Tsung-Ru Wu, Tsung-Teng Huang, Jan Martel, Jian-Ching Liau, Chen-Yaw Chiu, Yann-Lii Leu, Wei-Ting Jian, I-Te Chang, Chia-Chen Lu, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai*, John D. Young*. Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells. Journal of Ethnopharmacology. 2017 Apr 6;201:117-122.SCIIF:3.055
  2. Jan Martel, David Ojcius, Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Yun-Fei Ko, Shun-Fu Tseng, Hsin-Chih Lai, and John Young*. Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nature Review Endocrinology. 2017 Mar;13(3):149-160. Review.SCIIF:15.432
  3. Chin-Chung Shu, Jann-Yuan Wang, Ming-Fang Wu, Chen-Tu Wu, Hsin-Chih Lai, Li-Na Lee, Bor-Luen Chiang* & Chong-Jen Yu*. Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes. Scientific Reports. 2017 Feb 7 ;7:42004.SCIIF:5.228
  4. Chun-Hung Yang, Heng-Yuan Chang, Yi-Chuan Chen, Chia-Chen Lu, Shyh-Shyun Huang, Guan-Jhong Huang*, Hsin Chih Lai*. Ethanol extract of Phellinus merrillii protects against Diethylnitrosamine- and 2-Acetylaminofluorene-induced Hepatocarcinogenesis in Rats. Chinese Journal of Integrative Medicine. 2017 Feb;23(2):117-124.SCIIF:1.234
  5. Yun-Fei Ko, Jian-Ching Liau, Chien-Sheng Lee, Chen-Yaw Chiu, Jan Martel, Chuan-Sheng Lin, Shun-Fu Tseng, David M. Ojcius, Chia-Chen Lu, Hsin-Chih Lai, John D. Young*. Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body. PLoS One. 2017 Jan 3;12(1): e0168734. SCI IF:3.057
  6. Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tsung-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel4, David M. Ojcius, Hsin-Chih Lai* & John D. Young*. An iron detection system determines bacterial swarming initiation and biofilm formation. Scientific Reports. 2016 Nov 15; 6:36747.SCIIF:5.228
  7. Hsin-Chih Lai, Yu-Tze Horng, Pen-Fang Yeh, Jann-Yuan Wang, Chin-Chung Shu,Chia-Chen Lu, Jang-Jih Lu, Jen-Jyh Lee and Po-Chi Soo*. The assessment of host and bacterial proteins in sputum from active pulmonary tuberculosis. Journal of Microbiology. 2016 Nov;54(11):761-767.SCIIF:1.621
  8. Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai* and John D. Young*. Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. Innate Immunity. 2016 Oct;22(7):522-33.SCIIF:2.83
  9. Hwai-Jeng Lin, Fang-Yu Hsu, Wei-Wei Chen, Che-Hsin Lee, Ying-Ju Lin, Yi-Ywan M. Chen, Chih-Jung Chen, Mei-Zi Huang, Min-Chuan Kao, Yu-An Chen, Hsin-Chih Lai and Chih-Ho Lai*. Helicobacter pylori Activates HMGB1 Expression and Recruits RAGE into Lipid Rafts to Promote Inflammation in Gastric Epithelial Cells. Frontiers in Immunology. 2016 Sep 9;7:341.SCIIF:5.695
  10. Chia-Hao Lin, Chih-Yu Chi, Han-Po Shih, Jing-Ya Ding, Chia-Chi Lo, Shang-Yu Wang,Chen-Yen Kuo, Chun-Fu Yeh, Kun-Hua Tu, Shou-Hsuan Liu, Hung-Kai Chen, Chen-Hsuan Ho, Mao-Wang Ho, Chen-Hsiang Lee, Hsin-Chin Lai & Cheng-Lung Ku*. Identification of a major epitope by anti-interferon-γ autoantibodies in patients with mycobacterial disease. Nature Medicine. 2016 Sep;22(9):994-1001SCIIF:30.357
  11. Patricia T. Santana, Jan Martel, Hsin-Chih Lai, Jean-Luc Perfettini*, Jean M. Kanellopoulos, John D. Young, Robson Coutinho-Silva, David M. Ojcius*. Is the inflammasome relevant for epithelial cell function? Microbes and Infection. 2016 Feb;18(2):93-101.SCIIF:2.291
  12. Briliant Adhi Prabowo, Li-Chen Su, Ying-Feng Chang, Hsin-Chih Lai*, Nan-Fu Chiu, Kou-Chen Liu*. Performance of white organic light-emitting diode for portable optical biosensor. Sensors and Actuators B. 2016 January; 222:1058-1065SCIIF:4.758
  13. Tsung-Teng Huang, Hsin-Chih Lai, Yun-Fei Ko, David M. Ojcius, Ying-Wei Lan, Jan Martel, John D. Young *& Kowit-Yu Chong*. Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo. Scientific Reports. 2015 Oct 26;5:15282. SCIIF:5.228
  14. Agnes Purwidyantri, Hsin-Chih Lai, Sheng-Hui Tsai, Ji-Dung Luo, Chiuan-Chian Chiou, Ya-Chung Tian, Chi-Hui Cheng, Yi-Ting Lin, Chao-Sung Lai*. Sensing performance of fibronectin-functionalized Au-EGFET on the detection of S. epidermidis biofilm and 16S rRNA of infection-related bacteria in peritoneal dialysis. Sensors and Actuators B. 2015 Oct 1;217: 92-99.SCIIF:4.758
  15. Sheng-Hui Tsai, Hsin-Chih Lai, Shiau-Ting Hu. Subinhibitory Doses of Aminoglycoside Antibiotics Induce Changes in the Phenotype of Mycobacterium abscessus. Antimicrob Agents and Chemother. 2015 Oct;59(10):6161-9. IF:4.415
  16. Chih-Jung Chang, Chuan-Sheng Lin, Chia-chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young*, Hsin-Chih Lai*. Ganoderma lucidum reduces obesitly in mice by modulating the composition of the gut microbiota. Nature Communications. 2015 Jun 23;6:7489.SCIIF:11.329
  17. Chuan-Sheng Lin, Chih-Cheng Su, Shang-Chen Hsieh, Chia-Chen Lu, Tsu-Lan Wu, Ju-Hsin Jia, Ting-Shu Wu, Chau-Chung Han, Wen-Cherng Tsai, Jang-Jih Lu*, Hsin-Chih Lai*. Rapid identification of Mycobacterium avium clinical isolates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Microbiology, Immunology and Infection. 2015 Apr;48(2):205-212. SCIIF:2.995
  18. Chin-Chung Shu, Jann-Yuan Wang, Chia-Lin Hsu, Li-Ta Keng, Kochung Tsui, Jeng-Feng Lin, Hsin-Chih Lai, Chong-Jen Yu*, Li-Na Lee, Kwen-Tay Luh. Diagnostic role of inflammatory and anti-inflammatory cytokines and effector molecules of cytotoxic T lymphocytes in tuberculous pleural effusion. Respirology. 2015 Jan;20(1):147-54.SCIIF:3.078
  19. Tsai-Hsien Hung, Sheng-Chi Hsu, Ching-Yi Cheng, Kong-Bung Choo, Ching-Ping Tseng, Tse-Ching Chen, Ying-Wei Lan, Tsung-Teng Huang, Hsin-Chih Lai, Chuan-Mu Chen and Kowit-Yu Chong*. Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway. Oncotarget. 2014 Dec 15;5(23):12273-90. SCIIF:5.008
  20. Chia-Chen Lu, Ting-Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, John D. Young*, and Hsin-Chih Lai*. NK cells kill mycobacteria directly by releasing perforin and granulysin. Journal of Leukocyte Biology. 2014 Dec;96(6):1119-1129.SCIIF:4.165
  21. Jan Martel, David M. Ojcius, HsinChih Lai, John D. Young*. Mushrooms - From cuisine to clinic. Biomed J. 2014 Nov-Dec;37(6):343-344.
  22. Tsung-Teng Huang, Hsin-Chih Lai*, Young-Bin Chen, Lih-Geeng Chen, Yi-Hui Wu, Yun-Fei Ko, Chia-Chen Lu, Chih-Jung Chang, Cheng-Yeu Wu, Jan Martel, David M Ojcius, Kowit-Yu Chong, John D Young. cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophages. Innate Immun. 2014 Oct;20(7):735-50.SCIIF:2.83
  23. Chuan Sheng Lin, Chih Jung Chang, Chia Chen Lu, Jan Martel, David M. Ojcius1, Yun Fei Ko, John D. Young*, Hsin Chih Lai*. Impact of the Gut Microbiota, Prebiotics, and Probiotics on Human Health and Disease. Biomed J. 2014 Sep-Oct;37(5):259-68.
  24. Nan-Fu Chiu*, Teng-Yi Huang, Hsin-Chih Lai and Kou-Chen Liu. Graphene oxide-based SPR biosensor chip for immunoassay applications. Nanoscale Research Letters. 2014 Aug 28;9(1):445.SCIIF:2.584
  25. Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius, Yi-Hui Wu, Yun-Fei Ko, Cheng-Yeu Wu, Jan Martel, Chia-Chen Lu, Hsin-Chih Lai* & John D. Young*. The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome. Journal of Ethnopharmacology. 2014 Aug 8;155(1):154-64.SCIIF:3.055
  26. Briliant Adhi Prabowo, Ying-Feng Chang,Yu-Ying Lee, Li-Chen Su, Chih-Jen Yu, Yen-Heng Lin, Chien Chou, Nan-Fu Chiu, Hsin-Chih Lai*, Kou-Chen Liu*. Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor. Sensors and Actuators B. 2014 July 31; 198: 424-430.SCIIF:4.758
  27. Chun-Hung Yang, Hui-Ling Wang , Yi-Sheng Lin , K. P. Shravan Kumar, Hung-Chi Lin, Chih-Jung Chang, Chia-Chen Lu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, Yu-Sun Chang, John D. Young* , Hsin-Chih Lai*. Identification of CD24 as a Cancer Stem Cell Marker in Human Nasopharyngeal Carcinoma. PLoS One. 2014 Jun 23;9(6):e99412.SCIIF:3.057
  28. Chih-Jung Chang, Yi-Yuan M Chen, Chia-Chen Lu, Chuan-Sheng Lin, Jan Martel, Sheng-Hui Tsai, Yun-Fei Ko, Tsung-Teng Huang, David M Ojcius, John D Young, Hsin-Chih Lai*. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun. 2014 Apr;20(3):301-311.SCIIF:2.83
  29. Po-Chi Soo, Yu-Tze Horng, Yung-Lin Chang, Wei-Wen Tsai, Wen-Yih Jeng, Chia-Chen Lu*, Hsin-Chih Lai*. ManA is regulated by RssAB signaling and promotes motility in Serratia marcescens. Research in Microbiology 2014 Jan;165(1):21-29.SCIIF:2.154
  30. Ju-Hsin Chia, Hsin-Chih Lai, Lin-Hui Su, An-Jing Kuo, Tsu-Lan Wu*. Molecular Epidemiology of Clostridium difficile at a Medical Center in Taiwan: Persistence of Genetically Clustering of A-B+ Isolats and Increase of A+B+ Isolates. PLoS One. 2013 Oct 7;8(10):e75471.SCIIF:3.057
  31. Sheng-Hui Tsai, Gwan-Han Shen, Chao-Hsiung Lin, Jiue-Ru Liau, Hsin-Chih Lai, Shiau-Ting Hu*. Mab_3168c, a putative acetyltransferase, enhances adherence, intracellular survival and antimicrobial resistance of Mycobacterium abscessus. PLoS One. 2013 Jun 28;8(6):e67563.SCIIF:3.057
  32. Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius, Yi-Hui Wu, Yun-Fei Ko, Cheng-Yeu Wu, Jan Martel1,, Chia-Chen Lu, Hsin-Chih Lai* & John D. Young*. Hirsutella sinensis mycelium suppresses interleukin-1b and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. Scientific Reports. 2013 Mar 5; 3(1):1374.SCIIF:5.228
  33. Hsin-Chih Lai, Chih-Jung Chang, Chun-Hung Yang, Ya-Jing Hsu, Chang-Chieh Chen, Chuan-Sheng Lin, Yu-Huan Tsai, Tsung-Teng Huang, David M. Ojcius, Ying-Huang Tsai, and Chia-Chen Lu. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. Journal of Leukocyte Biology. 2012 Oct;92(4):807-814.SCIIF:4.165
  34. Chia-Chen Chang, Shenhsiung Lin, Chung-Han Lee, Tsung-Liang Chuang, Po-Ren Hsueh, Hsin-Chih Lai, Chii-Wann Lin*. Amplified surface plasmon resonance immunosensor for interferon-Gamma based on a streptavidin-incorporated aptamer. Biosensors & Bioelectronics. 2012 Aug-Sep;37(1):68-74.SCIIF:7.476
  35. Tsung-Teng Huang, David M. Ojcius, John D. Young, Yi-Hui Wu, Yun-Fei Ko, Tsui-Yin Wong, Cheng-Yeu Wu, Chia-Chen Lu, Hsin-Chih Lai*. The Anti-Tumorigenic Mushroom Agaricus blazei Murill Enhances IL-1β Production and Activates the NLRP3 Inflammasome in Human Macrophages. PLoS ONE. 2012 Jul 23;7(7):e41383.SCIIF:3.057
  36. Ting-Shu Wu, Cheng-Hsun Chiu, Chih-Hsun Yang, Hsieh-Shong Leu, Ching-Tai Huang, Yi-Chieh Chen, Tsu-Lan Wu, Pi-Yueh Chang, Lin-Hui Su, An-Jing Kuo, Ju-Hsin Chia, Chia-Chen Lu, Hsin-Chih Lai*.  Fish Tank Granuloma Caused by Mycobacterium marinum. PLoS ONE. 2012 Jul 20;7(7):e41296.SCIIF:3.057
  37. Shang-Chen Hsieh; Chia-Chen Chang; Chia-Chen Lu; Chia-Fong Wei; Chuan-Sheng Lin; Hsin-Chih Lai*; Chii-Wann Lin*. Rapid identification of Mycobacterium tuberculosis infection by a new array format-based surface plasmon resonance method. Nanoscale Research Letters.2012 Mar 8;7(1):180.SCIIF:2.584
  38. Chang-Chieh Chen, Sheng-Hui Tsai, Chia-Chen Lu, Shiau-Ting Hu, Ting-Shu Wu, Najwane Said, David M. Ojcius, Hsin-Chih Lai*. Activation of an NLRP3 Inflammasome Restricts Mycobacterium kansasii Infection. PLoS ONE. 2012 Apr 30; 7(4):e36292.SCIIF:3.057
  39. Ju-Hsin Chia, Tsu-Lan Wu, Lin-Hui Su, An-Jing Kuo, Hsin-Chih Lai*. Direct identification of mycobacteria from smear-positive sputum samples using an improved multiplex polymerase chain reaction assay. Diagnostic Microbiology and Infectious Disease. 2012 Apr;72(4):340-9SCIIF:2.450
  40. Yu-Huan Tsai, Jun-Rong Wei, Yu-Ching Lin, Chuan-Sheng Lin, Po-Han Chen, Stella Huang, Chia-Fong Wei, Chia-Chen Lu, Hsin-Chih Lai*. RssAB signaling coordinates early development of surface multicellularity in Serratia marcescens. PLoS ONE. 2011 Aug 26;6(8):e24154.SCIIF:3.057
  41. Tsung-Teng Huang, Hung-Chi Lin, Chang-Chieh Chen, Chia-Chen Lu, Chia-Fong Wei, Ting-Shu Wu, Fu-Guo Liu, Hsin-Chih Lai*. Resveratrol induces apoptosis of human nasopharyngeal carcinoma cells via activation of multiple apoptotic pathways. Journal of Cellular Physiology. 2011 Mar;226(3):720-728.SCIIF:4.155
  42. Tsung-Teng Huang, Fu-Guo Liu, Chia-Fong Wei, Chia-Chen Lu, Chang-Chieh Chen, Hung-Chi Lin, David M Ojcius, Hsin-Chih Lai*. Activation of Multiple Apoptotic Pathways in Human Nasopharyngeal Carcinoma Cells by the Prenylated Isoflavone, Osajin. PLoS ONE. 2011 Apr 12;6(4):e18308.SCIIF:3.057
  43. Bor-Ching Sheu, Chih-Chen Lin, Ying-Hsien Fu, Shih-Yuan Lee, Hsin-Chih Lai, Rung-Shin Wu, Chih-Hao Liu, Jui-Chang Tsai and Shiming Lin. Unraveling the role of the rssC gene of Serratia marcescens by atomic force microscopy. Microscopy and Microanalysis. 2010 Dec;16(6):755-63.SCIIF:1.730
  44. Chuan-Sheng Lin, Jim-Tong Horng, Chun-Hung Yang, Yu-Huan Tsai, Lin-Hui Su, Chia-Fong Wei, Chang-Chieh Chen, Shang-Chen Hsieh, Chia-Chen Lu and Hsin-Chih Lai*. RssAB-FlhDC-ShlBA as a Major Pathogenesis Pathway in Serratia marcescens. Infection and Immunity. 2010 Nov;78(11):4870-81.SCIIF:3.603
  45. Yu-Tze Horng, Kai-Chih Chang, Yen-Ni Liu, Hsin-Chih Lai*, Po-Chi Soo*. The RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic, prodigiosin, in Serratia marcescens. International Journal of Medical Microbiology. 2010 Jun;300(5):304-12.SCIIF:2.269
  46. Po-Chi Soo; Yu-Tze Horng; Kai-Chih Chang; Jann-Yuan Wang; Po-Ren Hsueh; Chun-Yu Chuang; Chia-Chen Lu; Hsin-Chih Lai*. A simple Gold Nanoparticle Probes assay for identification of Mycobacterium tuberculosis and Mycobacterium tuberculosis complex from Clinical Specimens. Molecular and Cellular Probes. 2009 Oct;23(5):240-6.SCIIF:1.565
  47. Ting-Shu Wu, Hsieh-Shong Leu, Cheng-Hsun Chiu, Ming-Hsun Lee, Ping-Cherng Chiang, Tsu-Lan Wu, Ju-Hsin Chia, Lin-Hui Su, An-Jing Kuo, Hsin-Chih Lai*. The clinical manifestations, antibiotic susceptibility and molecular analysis of Mycobacterium kansasii isolates from a university hospital in Taiwan. Journal of Antimicrobial Chemotherapy. 2009 Sep;64(3):511-4.SCIIF:4.919
  48. Ting-Shu Wu, Chia-Chen Lu and Hsin-Chih Lai*. Current Situations on Identification of Nontuberculous Mycobacteria. Journal of Biomedical and Laboratory Sciences. 2009 Api; 21(1):1-6. (EI)
  49. Tsu-Lan Wu, Ju-Hsin Chia, An-Jing Kuo, Lin-Hui Su, Ting-Shu Wu and Hsin-Chih Lai*. 2008 Nov. Rapid Identification of Mycobacteria from Smear Positive Sputum Samples by Nested PCR-Restriction Fragment Length Polymorphism Analysis. Journal of Clinical Microbiology. 2008 Nov;46(11):3591-4.SCIIF:3.631