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趙崇義教授

(DANIEL TSUN-YEE CHIU)

學歷

美國加州大學戴維斯分校生化學博士

 

任課科目

臨床血液學(及實驗)、自由基生物醫學、生物技術實驗、細胞生物學、醫學生物研究論文寫作

研究專長

醫技(血液學)、自由基生物醫學、溶血性貧血(G6PD缺乏症,海洋性貧血等)、細胞生物學

辦公室分機

5097/3505

實驗室分機

3708

個人網頁

自由基生物醫學暨
預防醫學檢驗研究室

E-mail

dtychiumail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

甲.氧化壓力(Oxidative Stress)對細胞功能及人類健康之影響

超氧陰離子及一氧化氮等自由基是促使吞噬作用,訊息傳遞及基因表達等正常生物運作不可缺之化學物。但此等自由基也是造成細胞老化(apoptosis)及許多慢性病(如癌症、心血管疾病、免疫力下降,腦功能衰退及白內障等)之主要因素。有鑑於此,本研究室乃以G6PD缺乏症為模型來探討氧化壓力如何影響細胞之結構與功能並進一步探討G6PD缺乏症患者是否比正常人容易罹患一些慢性病。

 體研究題目如下列:

◆ 氧化壓力對細胞功能之影響(G6PD缺乏之細胞為模型)

Effects of oxidative stress on cellular function.

(G6PD-deficient cell as a model system.)

應用RNAi等分生技術建立了各種G6PD缺乏之細胞株並應用蛋白質體(Proteomic)及代謝體(Metabolomic)等新的生物技術去探討氧化壓力對細胞功能之影響。

 ◆ 抗氧化劑之研發。

Development of antioxidants

 

乙.血液相關之研究

血液病之研究(如海洋性貧血及G6PD缺乏症其病體生理

(Pathophysiology)之深入探討)及從基因(Genomic)及蛋白(Proteomic)之層次探討G6PD缺乏症。

 

丙.建立診斷中心(Reference Laboratories)

氧化壓力及抗氧化劑評估中心Reference laboratory to assess oxidative stress and antioxidant capacity.

研發更敏感的檢測方法如CoulArray HPLC去檢測氧化壓力並建立代謝體(Metabolomic)的檢測技術,再合併生物資訊(Bioinformatic)之分析方法去評核氧化壓力在退化性疾病中所扮演之角色。

論文與著作(Publication)

最近五年所發表論文 

1.  Cheng ML, Chen CM, Li JM, Ho HY, Chiu DTY* (2009 Feb) Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin E levels.  Am J Cardiol.  103:471-5 (SCI IF=3.209)

2.   Wu YH, Cheng ML, Ho HY, Chiu DTY*, Wang TC* (2009 Feb) Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.  J Biomed Sci. 16:Articl #18 (online publication)(SCI IF=2.339)

3.   Chen CM, Liu JL, Wu YR, Chen YC, Cheng ML, Chiu DTY* (2009 Mar) Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease.  Neurobiol Dis. 33:429-35 (SCI IF=5.624)

4.  Ho HY, Cheng ML, Weng SF, Leu YL, Chiu DTY* (2009 Jul) Antiviral Effect of Epigallocatechin Gallate on Enterovirus 71.  J Agric Food Chem. 57:6140-7 (SCI IF=2.906)

5.    Gao LP, Cheng ML, Chou HJ, Yang YH, Ho HY, Chiu DTY* (2009 Sep) Ineffective GSH regeneration enhances G6PD knockdown Hep G2 cells to diamide induced-oxidative damage.   Free Radic Biol Med.  47:529-35 (SCI IF=5.271)

6.   Lin CJ, Cheng ML, Ho HY, Cheng TH, Yu JS, and Chiu DTY* (2010 Aug) Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H2O2-induced apoptosis.  Free Radic Biol Med.  49:361-73 (SCI IF=5.271)

7.  Yang HC, Cheng ML, Ho HY, Chiu DTY* (2011 Feb) The microbicidal and cytoregulatory roles of NADPH oxidases.  Microbes Infect. 13:109-20 (SCI IF=2.92)

8.    Chen KH, Cheng ML, Jing YH, Chiu DTY, Shiao MS, Chen JK (2011 Nov) Resveratrol ameliorates metabolic disorders and muscle wasting in streptozotocin-induced diabetic rats.  Am J Physiol-Endoc M.  301: E853-63(SCI IF=4.514)

9.    Cheng ML, Shiao MS, Chiu DTY, Weng SF, Tang HY, Ho HY (2011 Dec) Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics.  Biochem Pharmacol. 82:1549-61(SCI IF=4.576)

10. Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DTY* (2011 Dec) Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.  J Neurosurg. 115:1184-90 (SCI IF=3.148)

11. Cheng ML, Ho HY, Shiao MS, Chiu DTY* (2013 Jan) Characterization of global metabolic responses of glucose-6-phosphate dehydrogenase-deficient hepatoma cells to diamide-induced oxidative stress.  Free Radical Bio Med. 54:71-84 (SCI IF=5.271)

12.  Yang HC, Chen TL, Wu YH, Cheng KP, Lin YH, Cheng ML, Ho HY, Lo SJ*Chiu DTY*  (2013 May) Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death Dis. 4:e616. doi: 10.1038/cddis.2013.132 (SCI IF=6.044)

13. Lin HR, Wu CC, Wu Y, Hsu CW, Cheng ML, Chiu DTY* (2013 Jul) Proteome-wide dysregulation by G6PD reveals a novel protective role for G6PD in aflatoxin B1-mediated cytotoxicity.  J Proteome Res. 12:3434-48 (SCI IF=5.056)

14. Cheng ML, Ho HY*, Lin HY, Lai YC, Chiu DTY* (2013 Sep) Effective NET formation in neutrophils from individuals with G6PD Taiwan-Hakka is associated with NADP+ biosynthesis.  Free Radical Res. 47:699-709 (SCI IF=3.279)

15.  Ho HY, Cheng ML, Chiu DTY*(2014 May) Glucose-6-Phosphate Dehydrogenase - Beyond the Realm of Red Cell Biology.  Free Radic Res.  [Epub ahead of print] (SCI IF=3.279)