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趙崇義教授

(DANIEL TSUN-YEE CHIU)

學歷

美國加州大學戴維斯分校生化學博士

 

任課科目

臨床血液學(及實驗)、自由基生物醫學、生物技術實驗、細胞生物學、醫學生物研究論文寫作

研究專長

醫技(血液學)、自由基生物醫學、溶血性貧血(G6PD缺乏症,海洋性貧血等)、細胞生物學

辦公室分機

5097/3505

實驗室分機

3708

個人網頁

自由基生物醫學暨
預防醫學檢驗研究室

E-mail

dtychiumail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

甲.氧化壓力(Oxidative Stress)對細胞功能及人類健康之影響

超氧陰離子及一氧化氮等自由基是促使吞噬作用,訊息傳遞及基因表達等正常生物運作不可缺之化學物。但此等自由基也是造成細胞老化(apoptosis)及許多慢性病(如癌症、心血管疾病、免疫力下降,腦功能衰退及白內障等)之主要因素。有鑑於此,本研究室乃以G6PD缺乏症為模型來探討氧化壓力如何影響細胞之結構與功能並進一步探討G6PD缺乏症患者是否比正常人容易罹患一些慢性病。

 體研究題目如下列:

◆ 氧化壓力對細胞功能之影響(G6PD缺乏之細胞為模型)

Effects of oxidative stress on cellular function.

(G6PD-deficient cell as a model system.)

應用RNAi等分生技術建立了各種G6PD缺乏之細胞株並應用蛋白質體(Proteomic)及代謝體(Metabolomic)等新的生物技術去探討氧化壓力對細胞功能之影響。

 ◆ 抗氧化劑之研發。

Development of antioxidants

 

乙.血液相關之研究

血液病之研究(如海洋性貧血及G6PD缺乏症其病體生理

(Pathophysiology)之深入探討)及從基因(Genomic)及蛋白(Proteomic)之層次探討G6PD缺乏症。

 

丙.建立診斷中心(Reference Laboratories)

氧化壓力及抗氧化劑評估中心Reference laboratory to assess oxidative stress and antioxidant capacity.

研發更敏感的檢測方法如CoulArray HPLC去檢測氧化壓力並建立代謝體(Metabolomic)的檢測技術,再合併生物資訊(Bioinformatic)之分析方法去評核氧化壓力在退化性疾病中所扮演之角色。

論文與著作(Publication)

最近五年所發表論文 

  1. Ho HY, Cheng ML, Chiu DTY*(2014)Glucose-6-Phosphate Dehydrogenase - Beyond the Realm of Red Cell Biology.  Free Radical Res. 48:1028-48 (SCI)
  2. Chiu DTY (2014) Oxidative stress in biology and medicine (Editorial Note).  Biomedical J. 37:97-8.
  3. Chiu DTY, Wei YH (2014) Special issue on “Oxidative stress and mitochondrial alterations in ageing and disease. (Editorial).  Free Radical Res. 48: 967-9. (SCI)
  4. Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML*, Chiu DTY* (2015) Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance.  Antioxid Redox Sign. 22: 744-59. (SCI)
  5. Yang HC, Cheng ML, Hua YS, Wu YH, Lin HR, Liu HY, Ho HY and Chiu DTY*(2015)Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-kB signaling pathway. J Inflamm-Lond. 12:34. (SCI)
  6. YH Wu, Chiu DTY+, Lin HR, Tang HY, Cheng ML, Ho HY*(2015) Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses-Basel. 7: 6689-706. (SCI)
  7. Chiu DTY (2016) Helmut Sies: A continuous presence in my scientific development. Arch Biochem Biophys. 595: 181-4.(SCI)  
  8. Lin HR, Wu YH, Yen WC, Yang CM*, Chiu DTY*(2016) Diminished COX-2/PGE2-mediated antiviral response due to impaired NOX/MAPK signaling in G6PD-knockdown lung epithelial cells. PLoS One. 11:e015346. (SCI)
  9. Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, ……., Lin SY, Chiu DTY, Lin SC* (2016)ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Mol Cell. 62:359-70. (SCI )
  10. Yang HC, Wu YH, Liu HY, Stern A, Chiu DTY* (2016)What has passed is prologue: New cellular and physiological roles of G6PD.  Free Radical Res. 50:1047-64. (SCI)
  11. Chen TL, Yang HC, Hung CY, Ou MH, Pan YY, Cheng ML, Stern Arnold, Lo SJ* and Chiu DTY*(2017)Impaired embryonic development in glucose 6-phosphate dehydrogenase deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death Dis. 8:e2545 (SCI)
  12. Wu YH, Lin HR, Lee YH, Huang PH, Wei HC, Stern A, Chiu DTY* (2017)A novel fine tuning scheme of miR-200c in modulating lung cell redox homeostasis. Free Radical Res. 51:591-603(SCI)
  13. Tang HY, Chiu DTY, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC, Cheng ML, Chen CM(2017) Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome. Scientific Reports. 7:8140
  14. Yang HC*, Hung CY, Pan YY, Lo SJ and Chiu DTY(2017) Lipidomic Analysis of Caenorhabditis elegans Embryos.  Bio Protoc. 7 (20).
  15. Wu YH, Lee YH, Shih HY, Chen SH, Cheng YC*, Chiu DTY*(2018)Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death Dis. 9:10. (SCI )
  16. Chou CA, Lin CN, Chiu DTY, Chen IW, Chen ST* (2018)Tryptophan as a surrogate prognostic marker for diabetic nephropathy. J Diabetes Invest. 9:366-74. (SCI)