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詹爾昌 教授

(Err-Cheng Chan)

學歷

美國普渡大學生物技術博士

http://mip.cgu.edu.tw/ezfiles/35/1035/img/90/teacher03.jpg


任課科目

儀器分析學及實驗、生物工業產品生產設施設計、生物技術智慧財產權、生物技術特論、生物分子分離純化技術、微生物應用技術

研究專長

生物技術、生物化學 、基因工程、 蛋白質工程

辦公室分機

5220

實驗室分機

5220

個人網頁

醫學生物技術研究室

E-mail

chanecmail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

1. 結核桿菌研究:針對結核桿菌之致病機制和致病菌之偵測進行研究研究。實驗室以肺纖維母細胞(WI-38 cell)為模式,探討結核桿菌其所分泌的蛋白對宿主細胞信號傳遞和基因表現之影響。此外,可靠非侵入性和簡單之檢驗試劑亦將開發。

2. 腫瘤標誌之研究:利用蛋白質體學方法探討大腸直腸癌、肺癌等腫瘤蛋白質的表現和其早期與預後檢驗方法之開發。並從事血清免疫試劑之研發。

3. 慢性阻塞性肺病(COPD):研究病患體內自體抗體的血清學研究,並探討患者血清中 anti-elastin 自體抗體濃度與其疾病嚴重性之相關性。

論文與著作(Publication)

 最近五年所發表論文 

  1. Chou YC, Lee D, Chang TM, Hsu YH, Yu YH, Chan EC, Liu SJ. Combination of a biodegradable three-dimensional (3D) - printed cage for mechanical support and nanofibrous membranes for sustainable release of antimicrobial agents for treating the femoral metaphyseal comminuted fracture. J Mech Behav Biomed Mater. 2017 Aug;72:209-218.

  2. Fan CW, Kuo YB, Lin GP, Chen SM, Chang SH, Li BA, Chan EC. Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer. Clin Chim Acta. 2017 Dec;475:157-163.

  3. Wu RS, Hong JJ, Wu JF, Yan S, Wu D, Liu N, Liu QF, Wu QW, Xie YY, Liu YJ, Zheng ZZ, Chan EC, Zhang ZM, Li BA. OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis. Oncotarget. 2017 Jun 13;8(24):39401-39416.

  4. Hsu YH, Lin CT, Yu YH, Chou YC, Liu SJ, Chan EC. Dual delivery of active antibactericidal agents and bone morphogenetic protein at sustainable high concentrations using biodegradable sheath-core-structured drug-eluting nanofibers. Int J Nanomedicine. 2016 Aug 17;11:3927-37.

  5. Lu YC, Chang JT, Chan EC, Chao YK, Yeh TS, Chen JS, Cheng AJ. miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers. J Cancer. 2016 Mar 20;7(6):650-5.

  6. Chang PY, Chen JS, Chang NC, Chang SC, Wang MC, Tsai SH, Wen YH, Tsai WS, Chan EC2,3, Lu JJ. NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing. Oncotarget. 2016 Jun 21;7(25):37566-37580.

  7. Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. Gastroenterology. 2016 Mar;150(3):659-671.

  8. Chang PY, Chen CC, Chang YS, Tsai WS, You JF, Lin GP, Chen TW, Chen JS, Chan EC. MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection. Oncotarget. 2016 Mar 1;7(9):10663-75.

  9. Kuo YB, Li YS, Chan EC. Rapid identification of HPV 16 and 18 by multiplex nested PCR-immunochromatographic test. J Virol Methods. 2015 Feb;212:8-11.

  10. Chen CY, Chen JS, Chou YP, Kuo YB, Fan CW, Chan EC. Antibody against N-terminal domain of phospholipid scramblase 1 induces apoptosis in colorectal cancer cells through the intrinsic apoptotic pathway. Chem Biol Drug Des. 2014 Jul;84(1):36-43.

  11. Kuo YB, Chen JS, Fan CW, Li YS, Chan EC. Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer. Clin Chim Acta. 2014 Jun 10;433:284-9.

  12. Chang PY, Kuo YB, Wu TL, Liao CT, Sun YC, Yen TC, Chan EC. Association and prognostic value of serum inflammation markers in patients with leukoplakia and oral cavity cancer. Clin Chem Lab Med. 2013 Jun;51(6):1291-300.

  13. Kuo YB, Chao M, Lee YH, Yeh CT, Chan EC. New enzyme-linked immunosorbent assay for detection of antibodies against hepatitis delta virus using a hepatitis delta antigen derived from a Taiwanese clone and comparison to the Abbott radioimmunoassay. Clin Vaccine Immunol. 2012 May;19(5):817-9.

 

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