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(Err-Cheng Chan)






生物技術、生物化學 、基因工程、 蛋白質工程








研究方向及研究室特色(Lab & Research Interest)

1. 結核桿菌研究:針對結核桿菌之致病機制和致病菌之偵測進行研究研究。實驗室以肺纖維母細胞(WI-38 cell)為模式,探討結核桿菌其所分泌的蛋白對宿主細胞信號傳遞和基因表現之影響。此外,可靠非侵入性和簡單之檢驗試劑亦將開發。

2. 腫瘤標誌之研究:利用蛋白質體學方法探討大腸直腸癌、肺癌等腫瘤蛋白質的表現和其早期與預後檢驗方法之開發。並從事血清免疫試劑之研發。

3. 慢性阻塞性肺病(COPD):研究病患體內自體抗體的血清學研究,並探討患者血清中 anti-elastin 自體抗體濃度與其疾病嚴重性之相關性。



1. Han,C.L.,Chen,J.S.,Chan,E.C,Wu,C.P.,Yu,K.H.,Chen,K.T.,Tsou,C.C., Tsai,C.F.,

Chien,C.W., Kuo,Y.B., Lin,P.Y., Yu,J.S., Hsueh,C., Chen,M.C., Chan,C.C.,

Chang,Y.S., Chen, Y.J. An informatics-assisted label-free approach for personalized

tissue membrane proteomics: case study on colorectal cancer. Molecular & Cellular

Proteomics. 2011. 10: 10.1074/mcp.M110.003087,1-15. Co-first author.

2. Tsao, K.C., Kuo, Y.B., Huang, C.G., Chau, S.W., Chan, E.C*. Performance of

rapid-test kits for the detection of the pandemic influenza A/H1N1 virus. Journal of

Virological Methods. 2011. 173:387-389.

3. Ueng, S.W.N., Yuan, L.J., Lin, S.S., Liu, S.J., Chan, E.C., Chen, K.T., Lee, M.S. In

vitro and in vivo analysis of a biodegradable poly(lactide-co-glycolide) copolymer

capsule and collagen composite system for antibiotics and bone cells delivery.

Journal of Trauma-Injury Infection and Critical Care. 2011. 70:1503-1509.

4. Fan C.W., Chan C.C., Chen K.T., Huang Y.S., Han C.L., Chen Y.J., Yu J.S., Chang

Y.S., Kuo Y.B., Chan E.C*. Identification of SEC61b and its autoantibody as

biomarkers for colorectal cancer. Clinica Chimica Acta. 2011. 412:887-893.

5. Kuo, Y.B., Fan, C.W., Chan, C.C., Hung, R.P., Hung, Y.S., Chen, K.T., Chang,

C.A., Yu, J.S., Chang, Y.S., Chan, E.C*. Identification of Phospholipid Scramblase

1 as a Biomarker and Determination of Its Prognostic Value for Colorectal Cancer.

Molecular Medicine. 2011. 17(1-2):41-47.

6. Chen J.S., Chou Y.P., Chen K.T., Hung R.P., Yu J.S., Chang Y.S., Chan E.C*.

Detection of annexin A autoantibodies in sera from colorectal cancer patients.

Journal of Clinical Gastroenterology. 2011. 45:125-132.

7. Chen, J.S., Kuo, Y.B., Chou, Y.P., Chang, C.C., Fan, C.W., Chen, K.T., Huang, Y.S.,

Chan, E.C*. Detection of autoantibodies against Rabphilin-3A-like protein as a

potential biomarker in patient's sera of colorectal cancer. Clinica Chimica Acta. 

2011. doi:10.1016/j.cca.2011.04.020

8. Chan CC, Fan CW, Kuo YB, Chen YH, Chang PY , Chen KT , Hung RP , Chan

EC*. Multiple serological biomarkers for colorectal cancer detection. International

Journal of Cancer. 2010. 126(7): 1683 – 1690.

9. Chen J.S., Chen K.T., Fan C.W., Han C.L., Chen Y.J., Yu J.S., Chang Y. S., Chien

C.W., Wu C.P., Hung R. P., Chan E.C*. Comparison of membrane fraction

proteomic profiles of normal and cancerous human colorectal tissues with

gel-assisted digestion and iTRAQ labeling mass spectrometry. FEBS Journal. 2010.


10. Kuo YB, Chang CA, Wu YK, Hsieh MJ, Tsai CH, Chen KT, Chen CY, Chan EC*.

  Identification and clinical association of anti-cytokeratin 18 autoantibody in COPD.

  Immunology Letters. 2010. 128: 131-136.

11. Chen JS, Chen KT, Fan WC, Yu JS, Chang YS and Chan EC*. Combined analysis

  of survivin autoantibody and carcinoembryonic antigen biomarkers for improved

  detection of colorectal cancer. Clinical Chemistry and Laboratory Medicine. 2010.


12. Tsao, K.C., Huang, C.G., Kuo, Y.B., Chang, T.C., Sun, C.F., Chang, C.A., Yang,

  S.L., Chan, E.C*. Prevalence of human papillomavirus genotypes in northern

  Taiwanese women. J Med Virol, 2010. 82: 1739-1745.

13. Wu YK, Chen KT, Kuo YB, Huang YS, Chan EC*. Quantitative detection of

  survivin in malignant pleural effusion for the diagnosis and prognosis of lung

  cancer. Cancer Letters. 2009. 273:331-335.

14. Cheng ML, Ho HY, Lin JF, Chen YC, Chan EC, Chiu DTY. Clinical relevance of

  plasma homocysteine levels in Taiwanese patients with coronary artery disease.

  BioFactors. 2009. 34(2): 125-134.

15. Tsai K.N., Chan E.C, Tsai T.Y., Chen K.T., Chen C.Y., Hung K, Chen C.M.

  Cytotoxic effect of recombinant mycobacterium tuberculosis CFP-10/ESAT-6

  protein on the crucial pathways of WI-38 cells. Journal of Biomedicine and

  Biotechnology. 2009.DOI: 10.1155/2009/917084.

16. Chuang C.L., Chen C.M., Wong W.S., Tsai K.N., Chan E.C, Jiang J.A. A robust

  correlation estimator and nonlinear recurrent model to infer genetic interactions in

  Saccharomyces cerevisiae and pathways of pulmonary disease in Homo sapiens.

  BioSystems. 2009.98(3)160-175.

17. Ueng SW, Lee MS, Lin SS, Chan EC, Liu SJ. Development of a biodegradable

  alginate carrier system for antibiotics and bone cells. Journal of Orthopaedic

  Research. 2007. 25(1):62-72.

18. Liu SJ, Chi PS, Lin SS, Ueng SW, Chan EC, Chen JK. Novel solvent-free

  fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for

  antibiotics and rhBMP-2 delivery. International Journal of Pharmaceutics. 2007.


19. Zhao D, Liu TZ, Chan EC, Fein H, Zhang X. A novel enzymatic method for

  determination of homocysteine using electrochemical hydrogen sulfide sensor.

      Frontiers in Bioscience. 2007. 12:3774-80.


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