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舒竹青副教授

舒 竹 青 (Shu, Jwu-Ching)

學歷

英國牛津大學生物化學博士

任課科目

臨床微生物學及實驗、醫學分子檢驗、細胞生物學、分子生物學醫檢概論高等細菌學、書報討論

研究專長

臨床細菌學、病原菌與宿主交互作用、分子流行病學

辦公室分機

3418

實驗室分機

3158

個人網頁

分子暨臨床細菌學研究室

E-mail

shujc@mail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

  1. 研究金黃葡萄球菌抗藥性及致病機轉:金黃葡萄球菌為臨床上最重要致病菌之一,在台灣地區為院內感染排名第一的單一菌種,含有多種致病因子可造成健康的嚴重威脅。而多重抗藥性金黃葡萄球菌日益增加,使得臨床治療上更為棘手。本實驗室主要探討抗生素的刺激對多重抗藥性金黃葡萄球菌致病因子表現的影響,同時探討抗藥基因的調控機轉,並研究金黃葡萄球菌生物膜的調控機制。
  2. 研究金黃葡萄球菌與宿主間交互作用:我們有興趣探討金黃葡萄球菌在不同刺激下,致病因子在動物模式內的表現,以及宿主對於金黃葡萄球菌感染的免疫反應。
  3. 分子流行病學的研究:本實驗室與長庚醫院合作,進行多重抗藥性病原菌分子流行病學的研究,以助於院內感染的控制與監控新興抗藥性病原菌的產生。

論文與著作(Publication)

最近五年所發表論文

  1. Shu JC, Chia JH, Kuo AJ, Su LH, Wu TL*. (2010). A 7-year surveillance for ESBL-producing Escherichia coli and Klebsiella pneumoniae at a university hospital in Taiwan: the increase of CTX-M-15 in the ICU. Epidemiology and Infection. 138: 253-63.
  2. Chiou CS, Li HY, Tung SK, Chen CY, Teng CH, Shu JC, Tseng JT, Hsu CY, Chen CC*. (2010). Identification of prophage gene z2389 in Escherichia coli EDL933 encoding a DNA cytosine methyltransferase for full protection of NotI sites. International Journal of Medical Microbiology. 300: 296-303.
  3. Lee IT, Lee CW, Tung WH, Wang SW, Lin CC, Shu JC, Yang CM*. (2010). Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. American Journal of Pathology. 176: 1671-84.
  4. Chen HY, Chen CC, Fang CS, Hsieh YT, Lin MH, Shu JC*. (2011). Vancomycin activates σB in vancomycin-resistant Staphylococcus aureus resulting in the enhancement of cytotoxicity. PLoS One. 6: e24472.
  5. Hsu CY, Lin MH, Chen CC, Chien SC, Cheng YH, Su IN, Shu JC*. (2011). Vancomycin promotes the bacterial autolysis, release of extracellular DNA, and biofilm formation in vancomycin-non-susceptible Staphylococcus aureus. FEMS Immunology and Medical Microbiology. 63: 236-47.
  6. Shu JC, Chia JH, Siu LK, Kuo AJ, Huang SH, Su LH, Wu TL*. (2012). Interplay between mutational and horizontally acquired resistance mechanisms and its association with carbapenem resistance amongst extensively drug-resistant Pseudomonas aeruginosa (XDR-PA). International Journal of Antimicrobial Agents. 39: 217-22.
  7. Lin MH#*, Shu JC#, Huang HY, Cheng YC. (2012). Involvement of Iron in Biofilm Formation by Staphylococcus aureus. PLoS One. 7: e34388.
  8. Chen LC, Chen JC, Shu JC, Chen CY, Chen SC, Chen SH, Lin CY, Lu CY, Chen CC*. (2012). Interplay of RsbM and RsbK controls the σB activity of Bacillus cereus. Environmental Microbiology. 14: 2788-99.
  9. Shu JC, Su LH, Chia JH, Huang SH, Kao YC, Lee SC, Wu TL*. (2013). Identification of a hidden outbreak due to the spread of a VIM-3-producing, extensive drug-resistant Pseudomonas aeruginosa (XDRPA) clone at a regional hospital in Taiwan. Epidemiology and Infection. 141: 1713-6.
  10. Hsieh YT, Lin MH, Ho HY, Chen LC, Chen CC*, Shu JC*. (2013). Glucose-6-phosphate dehydrogenase (G6PD)-deficient epithelial cells are less tolerant to infection by Staphylococcus aureus. PLoS One. 8: e79566.
  11. Shu JC, Soo PC, Chen JC, Hsu SH, Chen LC, Chen CY, Liang SH, Buu LM, Chen CC*. (2013). Differential regulation and activity against oxidative stress of Dps proteins in Bacillus cereus. International Journal of Medical Microbiology. 303: 662-73.
  12. Chen CJ, Lin MH, Shu JC, Lu JJ*. (2014). Reduced susceptibility to vancomycin in isogenic Staphylococcus aureus strains of sequence type 59: tracking evolution and identifying mutations by whole-genome sequencing. Journal of Antimicrobial Chemotherapy. 69: 349-54.
  13. Kuo AJ, Su LH, Shu JC, Wang JT, Wang JH, Fung CP, Chia JH, Lu JJ, Wu TL*. (2014). National surveillance on vancomycin-resistant Enterococcus faecium in Taiwan: emergence and widespread of ST414 and a Tn1546-like element with simultaneous insertion of IS1251-like and IS1678. PLoS One. 9: e115555.
  14. Shu JC, Su LH, Chiu CH, Kuo AJ, Liu TP, Lee MH, Su IN, Wu TL*. (2015). Reduced Production of OprM May Promote oprD Mutations and Lead to Imipenem Resistance in Pseudomonas aeruginosa Carrying an oprD-Group 1A Allele. Microbial Drug Resistance. 21: 149-57.
  15. Lin MH#, Shu JC#, Lin LP, Chong KY, Cheng YW, Du JF, Liu ST*. (2015). Elucidating the crucial role of poly N-acetylglucosamine from Staphylococcus aureus in cellular adhesion and pathogenesis. PLoS One. 10: e0124216.
  16. Hsu CY#, Shu JC#*, Lin MH, Chong KY, Chen CC, Wen SM, Hsieh YT, Liao WT. (2015). High glucose concentration promotes vancomycin-enhanced biofilm formation of vancomycin-non-susceptible Staphylococcus aureus in diabetic mice. PLoS One. In press.

#equal contribution  *corresponding author

 

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