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系主任簡介

沈 家 瑞 (Chia-Rui Shen)

Education

(學歷)

Ph.D.  1998   

Department of Pathology and Microbiology,

Faculty of Medicine, University of Bristol,

United Kingdom

 英國布里斯托大學病理與微生物學系博士

B.Sc. 1993             

Department of Medical Technology, College of

Medicine, National Cheng Kung University

成功大學醫事技術學系學士

http://mip.cgu.edu.tw/ezfiles/35/1035/img/1302/464218227.jpg

研究專長

免疫療法、醫學檢驗、疫苗發展、分子影像

Telephone

(電話):

03-2118800 ext 5200

Fax number (傳真):

03-2118698

E-mail

crshen@mail.cgu.edu.tw

    Training and working experience (專業工作經歷)

Jan. 2016 -              Associate Researcher, Department of Ophthalmology, Linkou Chang Gung Memorial Hospital 林口長庚醫院眼科部視網膜科副研究員

Jul. 2013 -Sep. 2013 Visiting Scholar, Genomic and Proteomic Center, Academia Sinica

                                中央研究院基因體中心訪問研究學人

Aug. 2010 -       Associate Professor, Department of Medical Biotechnology and Laboratory

                               Science, Chang Gung University 長庚大學醫學生物技術暨檢驗學系副教授

Dec. 2006 -Jan. 2007 Visiting Scholar, Department of Radiology, Washington University in

                                St. Louis, USA  美國華盛頓大學聖路易校區放射學系訪問學者

Jul. 2003 – present  考選部醫師、中醫師、醫檢師國家考試命題委員

Feb. 2000 - Jul. 2010  Assistant Professor, Department of Medical Biotechnology and

                                Laboratory Science, Chang University 

                                長庚大學醫學生物技術暨檢驗學系助理教授

Sep. 1998 - Feb.2000 Postdoctoral fellow, Institute of Biomedical Science, Academia

                                Sinica 中央研究院生物醫學研究所博士後研究學者

Aug. 1993 - Jul. 1994 Teaching Assistant, Department of Medical Technology, College of

                                 Medicine, National Cheng Kung University 成功大學醫事技術學系專任助教

Industrial experience (產學合作)

Jun.2018 -                 全葳生物科技公司

Jan.2018 -                 聖川生物科技公司

Jun.2017 - May2018   芯生代生物科技公司

Aug.2006 - Jun.2007  昕穎生物科技公司

Dec.2002 - May2003  遠東生物科技公司

Professional Qualification or Courses (專業證照)

輻射安全防護證書(2012)

人體試驗主持人考試及格證書(2008)

流式細胞分選儀FACSAria操作證書 (2007)

有機溶劑作業主管安全衛生教育訓練班第465期結業證書(2005)

操作γ射線設備Gamma Cell 3000 serial #296安全訓練證書(2004)

操作人員輻射安全訓練合格證書 (2004)

香港大學問題導向學習訓練營結業證書(2001, 2002)

實驗動物飼養管理合格證書 (2001)

醫事檢驗師執照 (1993)

Membership (專業學會)

American Association for the Advancement of Science (AAAS)

American Chemical Society (ACS)

British Society of Immunology (BSI)

The Federation of Clinical Immunology Societies (FOCIS)

中華民國醫事檢驗學會

中華民國免疫學會(理事2012-)

中華民國細胞與分子生物學學會

台灣幾丁質幾丁聚醣學會 (理事2008-)

台灣女科技人學會

台灣生物技術與生化工程學會(原中華生化工程學會)

Honors and Awards (獎項)

        2018科技部106年度大專學生研究計畫研究創作獎(擔任指導老師)

        2017科技部105年度大專學生研究計畫研究創作獎(擔任指導老師)

        2018醫檢學會107年度學生論壇第一名(擔任指導老師, 與郭瑞琳、溫巧尼共同指導 )

        2015長庚大學104年度優良教師教學獎

Book and Book Chapter:

藥理學原理:以病態生理學為基礎的藥物治療(Principles of Pharmacology:The Pathophysiologic Basis of Drug Therapy, 3/e)/ Golan D.E et al. 原著;沈家瑞等編譯(2015)/藝軒出版社 (ISBN 978-95-76169-98-4)

Advances in Chitin Science- vol XII, p196-199. (2010) Published by FEQ-UNICAMP , Brazil (ISBN978-85-64131-00-2)

臨床血清免疫學/Mary Louis Turgeon 原著; 郭永斌等編譯; 沈家瑞等審閱(2004)/合記出版社

Shen, CR (1998) T-cell specificity in autoimmune haemolytic anaemia. Ph.D. thesis, University of Bristol, University of Bristol, UK.

Elson, CJ, Shen, CR (1998) Anemia, autoimmune hemolytic in experimental model. In Encyclopedia of Immunology (p.91-93), 2nd Ed. Edited by Roitt, I.M. and Delves, P.J. Arnold.

Patents:

2015利用幾丁質引發之免疫反應檢測過敏性氣喘病人之檢驗方法。中華民國發明專利第I479152號。

2015 A Chitin-induced Immune Response Based Method for Diagnosing Allergic Asthma in Patients. USA Patent US9,005,899.

2012短片段干擾RNA(siRNA)核苷酸及其醫藥組合物及用途。中華民國發明專利第I378800號。

2010幾丁質酵素的快速且多樣化定性試劑組與方法。中華民國發明專利第I322889號。

2010 Development of asthma therapy with rAAV-mediated AMCase shRNA. USA Patent US 7,851,616.

2009單離之幾丁質水解蛋白質、DNA、重組載體、重組幾丁質水解蛋白質以及表現系統。中華民國發明專利第I314557號。

論文與著作(Publication)

  1. Shen CR (correspondence), Juang JH, Tsai ZT, Wu ST, Tsai FY, Wang JJ, Yen TC. Preparation, characterization and application of superparamagnetic iron oxide encapsulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride. Carbohydr Polym 2011 Mar; 84(1): 781- 787. Epub 2010 Aug. SCI=4.811 (CHEMISTRY, APPLIED, 5.56%)
  2. Lee MH, Chang JT, Yu FW, Shen CR (correspondence). The prevalence of IL-17–producing cells in patients with Nasopharyngeal carcinoma. J Biomed Lab Sci 2011 Mar; 23(1): 30-37.
  3. Shen CR, Wu ST, Tsai ZT, Wang JJ, Yen TC, Tsai JS, Liu CL. Characterization of the Quaternized chitosan-stabilized iron-oxide nanoparticles as a novel potential MRI contrast agent for cell tracking. Poly International 2011 Jun 60(6): 945-950. SCI=2.070(POLYMER SCIENCE, 36.05%)
  4. Chen JK, Yeh CH, Wang LC, Liou TH, Shen CR (correspondence), Liu CL. Chitosan, the marine functional food for a potent adsorbent of humic acid. Mar Drugs 2011 9, 2488-2498. SCI=3.503 (CHEMISTRY, MEDICINAL, 21.67%)
  5. Tsai JP, Lee MH, Hsu SC, Chen MY, Liu SJ, Chang JT, Liao CT, Cheng AJ, Chong P, Shen CR (correspondence), Chen HW. CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions. J Immunol 2012 189:1671-1679 SCI=4.856 (IMMUNOLOGY, 22.52%)
  6. Tsai ZT, Tsai FJ, Yang WC, Wang JF, Liu CL, Shen CR (correspondence), Yen TC. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential MRI T2 contrast agent. Mar Drugs2012; 10(11), 2403-2414. SCI=3.503 (CHEMISTRY, MEDICINAL, 21.67%)
  7. Hsu PH, Wei KC, Huang CY, Wen CJ, Yen TC, Liu CL, Lin YT, Chen JC, Shen CR (correspondence), Liu HL. Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound. PLoS One 2013 Feb; 8(2): e57682. SCI=2.806 (MULTIDISCIPLINARY SCIENCES, 23.44%)
  8. Shen CR, Liu CL, Lee HP, Chen JK. The identification and characterization of chitotriosidase activity in pancreatin from porcine pancreas. Molecules 2013 Mar; 148, 2978-2987. SCI=2.861 (CHEMISTRY, ORGANIC, 28.81%)
  9. Shen CR, Chen HW. Fatal attraction: tumor recruitment of myeloid-derived suppressor cells is mediated by IL-17-producing CD8+ T cells. Transl Gastrointest Cancer 2013 June; 2(S1):119-122. doi: 10.3978/j.issn.2224-4778.2013.05.25.
  10. Hwang YS, Chiang PR, Hong WH, Chiao CC, Chu IM, Hsiue GH, Shen CR (correspondence). Study in vivo intraocular biocompatibility of in situ gelation hydrogels: Poly (2-ethyl oxazoline)- block- poly (<epsilon>- caprolactone)- block- poly (2-ethyloxazoline) Copolymer, Matrigel and Pluronic F127. PLoS One 2013 July; (7): e67495. SCI=2.806 (MULTIDISCIPLINARY SCIENCES, 23.44%)
  11. Chen YS, Liu CL, Lee MH, Chen HW, Shen CR (correspondence). The role of Tc17 in cancer immunity and clinical associations. J Biomed Lab Sci 2013 Sep; 25(3): 77-83.
  12. Shen CR, Yang WC, Chen HW. The fate of regulatory T cells: survival or apoptosis. Cell Mol Immunol 2014 Jan; 11(1):11-13. doi:10.1038/cmi.2013.49. SCI=5.897 (IMMUNOLOGY, 17.22%)
  13. Chen YS, Shen CR (correspondence). Immune checkpoint blockade therapy: The 2014 Tang Prize in Biopharmaceutical Science. Biomed J 2015 38:5-8.
  14. Shen CR, Juang HH, Chen HS, Yang CJ, Wu CJ, Lee MH, Hwang YS, Kuo ML, Chen YS, Chen JK, Liu CL. The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma. Int J Mol Sci. 2015 Nov; 16(11): 27371-27377. SCI=3.226 (CHEMISTRY, MULTIDISCIPLINARY, 32.53%)
  15. Yang WC, Hwang YS, Chen YY, Liu CL, Shen CN, Hong WH, Lo SM, Shen CR (correspondence). Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells. Front Immunol 2017 Nov; 8: Article 1508. SCI=6.429 (IMMUNOLOGY, 13.91%)
  16. Lee MH, Chang TC, Liao CT, Chen YS, Kuo ML, Shen CR (correspondence). Interleukin 17 and Peripheral IL-17-Expressing T cells are Negatively Correlated with the Overall Survival of Head and Neck Cancer Patients. Oncotarget 2018 Jan; 9(11): 9825-9837. SCI=5.168 (ONCOLOGY, 20.28%).
  17. Yang WC, Hwang YS, Shen CR (correspondence) Interleukin-4. Encyclopedia of Life Sciences. 2018 (Accepted for publication)
  18. Chen YS, Huang TH, Liu CL, Chen HS, Lee MH, Chen HW, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther. 2018 Aug 4. doi: 10.1089/hum.2018.104. SCI=4.187 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 15.82%)

 

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