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詹爾昌老師實驗室(主持人資料)

主持人個人資料表

 

中文姓名

詹爾昌

英文姓名

ERR-CHENG CHAN

聯絡地址

長庚大學醫學生物技術暨檢驗學系桃園市龜山區文化一路259號

聯絡電話

(03)2118800轉5220

傳真號碼

(03)2118741

E-MAIL

chanec@mail.cgu.edu.tw

主要學歷

美國普渡大學 生物技術 博士

現職

長庚大學 醫學生物技術暨檢驗學系 教授

經歷

長庚大學 醫學生物技術暨檢驗學系 教授

Publication

  1. Chan, E.C*., Ueng, P., Chen, L.F. 1986. D-Xylose fermentation to ethanol by Schizosaccharomyces pombe cloned with xylose isomerase. Biotechnol. Lett. 8:231-234.

  2. Chan, E.C*, Ueng, P., Chen, L.F. 1989. Metabolism of D-xylose in Schizosaccharomyces pombe cloned with a xylose isomerase gene. Appl. Microbiol. Biotechnol. 31:524-528.

  3. Chan, E.C*., Eder, K., Ueng, P., Chen L.F. 1989. Integration and expression of the Escherichia coli xylose isomerase gene in Schizosaccharomyces pombe. J. Indus. Microbiol. 4:409-418.

  4. Chan, E.C* Kuo, J., Lin, H.P. 1991. Stimulation of n-alkane conversion to dicarboxylic acid by organic-solvent and detergent treated microbes. Appl. Microbiol. Biotechnol. 34:772-777.

  5. Lin, H.M., Chan, E.C., Chen, L.F. 1991. Disintegration of yeast cells by pressurized carbon dioxide. Biotechnol. Prog. 7:200-204

  6. Chen,S.C. Chan, E.C., Chen, L.F. 1991. Prediction of bed height in a self-aggregating yeast ethanol tower fermentation. Appl. Biochem. Biotechnol. 28/29:719-729.

  7. Chan, E.C*, Chen, L.F. 1992. Recovery of invertase from ethanol fermentation broth. Biotechnol. Lett. 14:573-576.

  8. Chan, E.C*, Tsai, H.L., Chen, H.L., Mou, D.G. 1993. Amplification of trp operon gene in bacterial chromosome to increase L-tryptophan biosynthesis. Appl. Microbiol. Biotechnol. 40:301-305.

  9. Chen, C.S., Chan, E.C., Gong, C.S., Chen, L.F. 1993. Effect of sugar consumption on ethanol fermentation in a tower fermentor packed with self-aggregating yeast. Appl. Biochem. Biotechnol. 39/40:491-508.

  10. Chan, E.C*., Lin, S.P. 1993. A rapid method for quantitative detection of L-tryptophan . Biotechnol. Techniq. 7:159-163.

  11. Chan E.C*. 1993. Disruption of targeted gene in bacterial chromosome by a temperature sensitive plasmid. Biochem. Biophy. Res. Comm. 194:525-530.

  12. Chan, E.C*. 1994. Cloning a mutated trp operon for the biosynthesis of an antifungal agent. Biotechnol. Lett. 16:1021-1026.

  13. Chan, E.C*. 1994. Genetic engineering to enhance the biosynthesis of an antibiotic agent.  J. Biomed. Lab. Sci. 6:49-53.

  14. Lin, Y.L., Chan, E.C*. 1995. The sphingomyelinase activity of Helicobacter pylori. (abstract) Gut 37:(Suppl 1) A29.

  15. Lin, Y.L, Lee, N., Chan, E.C*. 1996. Determination of the optimal liquid medium for enzyme expression by Helicobacter pyloir. J. Clin. Pathol. 49:818-820.

  16. Wan, L., Lue, M.Y., Chang, C.A., Lin, Y.L., Chan, E.C. 1996. Helicobacter pylori induces genes expression in human gastric cells identified by mRNA differential display. Biochem. Biophy. Res. Comm. 228:484-488.

  17. Chan E.C*., Lin Y.L. 1996.  Signal transduction and pepsinogen secretion in human gastric adenocarcinoma cells stimulated by Helicobacter pylori. (abstract) Gut 39:(Suppl 2) A72.

  18. Chan, E.C*., Chen, K.T., Lin, Y.L. 1996. Vacuolating toxin from Helicobacter pylori activates cellular signaling and pepsinogen secretion in human gastric adenocarcinoma cells. FEBS Lett. 399:127-130.

  19. Chan, E.C* 1996. Expression and purification of recombinant lysostaphin in Escherichia coli. Biotechnol. Lett. 18:833-838.

  20. Chan, E.C*., Kuo, J. 1997. Biotransformation of dicarboxylic acid by immobilized Cryptococcus cells. Enzyme Microbiol. Tech. 20:585-589.

  21. Chan, E.C*., Hsu, Y.S., Cheng, C.S. 1997. Continuous production of dicarboxylic acid by immobilized Pseudomonas aeruginosa cells. J. Fermen. Bioengineer. 83(2):157-160.

  22. Lin, Y.L., Chen, C.T., Chan E.C. 1998. Identification of nuetral and acidic sphingomyelinase inf Helicobacter pylori. FEBS Lett.. 423:249-253.

  23. Chan, E.C*., Lue, M.Y. Hsu, K.C., Fan, H.A. 1998. Identification of novel genes that are differentially expressed in human colorectal carcinoma. Biochim. Biophy. Acta  1407:263-266.

  24. Chan E.C*., Wu, T.Z., Lin, Y.L. 1998. Staphylolytically recombinant lysostaphin enhances concentration of interleukin-8 in normal human epidermal keratinocytes cell line. Biotech. Lett. 20:1051-1056.

  25. Chan, E.C*., Pan, M.R. 1998. A synthetic complement C1q-lide peptide selectively interacts with immune complexes. Biotech. Lett. 20:1119-1123.

  26. Chan, E.C., Hsu, K.C., Fan H.A. 1998. Identification of novel genes that are differentially expressed in human colorectal tumor tissue. J. Tumor Marker Oncol. 13:52-53. (Abstract)

  27. Lin, J.D., Chan, E.C., Weng, H.F., Sheu, C.A. 1998. Two-dimensional electrophoretic analysis of membranous protein from human thyroid tissues and cancer cell lines. Electrophoresis. 19:3213-3216.

  28. Chan E.C*. Lin, Y.L., Chen, C.T., 1999. Signaling pathway and pepsinogen secretion in Helicobacter pylori activated human gastric adenocarcinoma cells. Int. J. Mole. Med. 3:421-425.

  29. Lin, S.S, Lee. S.S., Ueng, S.W.N., Chan, E.C., Chen, K.T., Yang, C.Y., Chen C.Y. Chan Y.S. 1999. .In vitro elution of antibiotic from antibiotic-impregnated biodegradable calcium alginate wound dressing. J. Trauma: Injury, Infect. Critical Care. 47: 136-141.

  30. Liu, J. B., Chan, E.C., Lin, S.S., Tsai, CH.H., Wei, F.C., and Shih, C.H. 1999. In vitro elution of vancomycin from biodegradable beads. J. Biomed. Mater. Res. 48:613-620.

  31. Lin, S.S., Ueng, W.N., Liu, S.J., Chan, E.C., Chao E.K., Tsai, C.H., Wei, F.C. 1999. Development of a biodegradable antibiotic delivery system. Clin. Ortho. Rel. Res. 362:240-250.

  32. Ueng, S.W.N., Lee, S.S., Chan, E.C., Hsu, B.R.S. and Chen, K.T. 2000. Biodegradable alginate antibiotic beads. Clin. Ortho. Rel. Res. 380:250-259.

  33. Lin, J.D., Chan, E.C.,. Chao, T.C., Chen, K.T., Weng, H.F. 2000. Expression of sodium iodide symporter in metastatic and follicular human thyroid tissues. Ann. Oncology, 11:625-629.

  34. Shih, S.R., Li, Y.S., Chiou, C.C., Chan, EC*. 2000. Expression of caspid protein VP71 for use as antigen for the diagnosis of enterovirus 71 infection. J. Med. Virol. 61:228-234.

  35. Chan, EC* Chang, C.C., Li, Y.S., Chang C.A., Chiiou, C.C., Wu, T.Z. 2000. Purification and characterization of neutral sphingomyelinase from Helicobacter pylori. Biochemistry. US, 39:4838-4845.

  36. Liou, M.J., Lin, J.D., Chan, EC., Liu, F.H.,Chao, T.C., and Weng, H.F. 2000. Detection of mRNA of sodium iodine symporter in benign and malignant human thyroid tissues. Cancer Lett. 160:75-80.

  37. Hsu, D.L., Hsu, K.C., Fan H.A. Chan, EC* 2001.Matrix Gla protein gene is differentially expressed in human colorectal carcinoma cells. Cancer Lett. 165:63-69.

  38. Chiou, C.C., Chan, E.C* 2001. Helicobacter pylori infection induced alteration of gene expression in human gastric cells. Gut 5: 598-604.

  39. Chen, K.T., Lin, J.D., Chao. T.C., Hsueh, C., Chang, C.A., Weng, H.F., Chan, EC* 2001. Identifying differentially expressed genes associated with metastasis of follicular thyroid cancer by complementary DNA expression array. Thyroid 11:41-46.

  40. Wu, T.Z., Lo, Y.R., Chan, E.C. 2001. Exploring the recognized bio-mimicry materials for gas sensing. Biosensors Bioelectronics 16: 945-953.

  41. Chen, K.T., Lin, J.D., Chao. T.C., Hsueh, C., Chang, C.A., Weng, H.F., Chan, EC* 2001. Identifying differentially expressed genes associated with metastasis of follicular thyroid cancer by complementary DNA expression array. Thyroid 11:41-46.

  42. Ueng, S.W.N., Yuan, L.J. Lee, N., Lin, S.S., Liu, S.J., Chan, E.C., and Weng J.H. 2002. In vivo study of hot compressing molded 50:50 poly(DL-lactide-co-glycolide) antibiotic beads in rabbits. J. Ortho. Res. 20:654-661.

  43. Tsao, K.C., Chan, E.C., Luan, U.C, Chang, P.Y. and Shih, S.R. 2002. Responses of IgM for enterovirus 71 infection. J. Med. Virol. 68:574-580.

  44. Liu, S.J., Ueng, S.W.N., Lin, S.S., and Chan, E.C 2002. In vivo release of vancomycin from biodegradable beads. J. Biomed. Mater. Res. 63:807-813.

  45. Chiou, C.C., Chan, C.C., Li, Y.C., Chan, EC* 2003 Helicobacter pylori induces G2/M arrest in gastric adenocarcinoma cell line. Scan. J. Gastroenterol., 38:147-152

  46. Liou, M.J., Chan, E.C., Lin, J.D., Liu, F.H. Chao, T.C. 2003. Human telomerase reverse transcriptase (hTERT) gene expression in FNA samples from thyroid neoplasms. Cancer Lett. 191:223-227.

  47. Shih, S.R., Tsaum K.N., Chueh, C.C., and Chan, E.C*. 2003. Inhibition of enterovirus 71-induced apoptosis by allophycocyanin isolated from a blue-green alga spirulina platensis. J. Med. Virol. 70:119-125.

  48. Chiou C.C., Chang, P.Y., Chan, E.C., Wu, J.L., and Wu, J.T. 2003. Detection of 8-hydroxy-deoxyguanosine, a marker of oxidative DNA damage in urine: assay development and measurement in both bladder and prostate cancer. Clin. Chim. Acta 334: 87-94.

  49. Tseng, H.J., Chan, C.C., and Chan, E.C. 2004. Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase. Biochem. Biophys. Res. Communi. 314: 513-518.

  50. Ueng SW. Yuan LJ. Lee N. Lin SS. Chan EC. Weng JH. In vivo study of biodegradable alginate antibiotic beads in rabbits. Journal of Orthopaedic Research. 22(3):592-9, 2004.

  51. Wang G. Liu SJ. Ueng SW. Chan EC. 2004. The release of cefazolin and gentamicin from biodegradable PLA/PGA beads. International Journal of Pharmaceutics. 273(1-2):203-12.

  52. Fan CW. Chan CC. Chao CC. Fan HA. Sheu DL. Chan EC. 2004.Expression patterns of cell cycle and apoptosis-related genes in a multidrug-resistant human colon carcinoma cell line. Scandinavian Journal of Gastroenterology. 39(5):464-9, 2004.

  53. Fan CW. Fan HA. Hsu SH. Chan CC. Chen SY. Hsu YH. Chan EC. An in vitro short time-high dose drug exposure assay for predicting 5FU-resistance of colorectal cancer. Cancer Letters. 214(2):181-8, 2004.

  54. Liu SJ. Tsai YE. Wen-Neng Ueng S. Chan EC.2005. A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques. Biomaterials. 26(22):4662-9.

  55. Chan EC. Chang PY. Wu TL. Wu JT. 2005. Enzymatic assay of homocysteine on microtiter plates or a TECAN analyzer using crude lysate containing recombinant methionine gamma-lyase. Annals of Clinical & Laboratory Science. 35(2):155-60.

  56. Chen KT. Lin JD. Liou MJ. Weng HF. Chang CA. Chan EC. 2006.An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.Cancer Letters. 231(2):192-205.

  57. Luo JD. Chan EC. Shih CL. Chen TL. Liang Y. Hwang TL. Chiou CC.2006. Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe. Nucleic Acids Research. 34(2):e12, 2006.

  58. Ueng SW, Lee MS, Lin SS, Chan EC, Liu SJ. 2007. Development of a biodegradable alginate carrier system for antibiotics and bone cells. Journal of Orthopaedic Research. 25(1):62-72.

  59. Liu SJ, Chi PS, Lin SS, Ueng SW, Chan EC, Chen JK. 2007. Novel solvent-free fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for antibiotics and rhBMP-2 delivery. International Journal of Pharmaceutics. 330(1-2):45-53.

  60. Zhao D, Liu TZ, Chan EC, Fein H, Zhang X. A novel enzymatic method for determination of homocysteine using electrochemical hydrogen sulfide sensor. Frontiers in Bioscience. 2007 12:3774-80.

  61. Wu YK, Chen KT, Kuo YB, Huang YS, Chan EC*. 2009. Quantitative detection

of survivin in malignant pleural effusion for the diagnosis and prognosis of lung

cancer. Cancer Letters 273, 331–335.

  1. Cheng ML, Ho HY, Lin JF, Chen YC, Chan EC, Chiu DTY. Clinical relevance of

plasma homocysteine levels in Taiwanese patients with coronary artery disease.

BioFactors. 2009. 34(2): 125-134.

  1. Tsai K.N., Chan E.C., Tsai T.Y., Chen K.T., Chen C.Y., Hung K, Chen C.M. Cytotoxic effect of recombinant mycobacterium tuberculosis CFP-10/ESAT-6 protein on the crucial pathways of WI-38 cells. Journal of Biomedicine and Biotechnology. 2009.DOI: 10.1155/2009/917084.

  2. Chuang C.L., Chen C.M., Wong W.S., Tsai K.N., Chan E.C., Jiang J.A. A robust

correlation estimator and nonlinear recurrent model to infer genetic interactions in

Saccharomyces cerevisiae and pathways of pulmonary disease in Homo sapiens.

BioSystems. 2009.98(3)160-175.

  1. Chan CC, Fan CW, Kuo YB, Chen YH, Chang PY , Chen KT , Hung RP , Chan EC. Multiple serological biomarkers for colorectal cancer detection. International Journal of Cancer. 2009. 126(7): 1683 – 1690.

  2. Chen JS, Chen KT, Fan WC, Yu JS, Chang YS and Chan EC. Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer. Clin Chem Lab Med. 2010. DOI:10.1515/CCLM.2010.123.

  3. Kuo YB, Chang CA, Wu YK, Hsieh MJ, Tsai CH, Chen KT, Chen CY, Chan EC. Identification and clinical association of anti-cytokeratin 18 autoantibody in COPD. Immunology Letters. 2010. 128:131-136

  4. Chen, J.S., Kuo, Y.B., Chou, Y.P., Chang, C.C., Fan, C.W., Chen, K.T., Huang, Y.S.,Chan, E.C*. Detection of autoantibodies against Rabphilin-3A-like protein as a potential biomarker in patient's sera of colorectal cancer. Clinica Chimica Acta. 2011. doi:10.1016/j.cca.2011.04.020

  1. Chen J.S., Chou Y.P., Chen K.T., Hung R.P., Yu J.S., Chang Y.S., Chan E.C*.Detection of annexin A autoantibodies in sera from colorectal cancer patients.Journal of Clinical Gastroenterology. 2011. 45:125-132.

  2. Kuo, Y.B., Fan, C.W., Chan, C.C., Hung, R.P., Hung, Y.S., Chen, K.T., Chang, C.A., Yu, J.S., Chang, Y.S., Chan, E.C*. Identification of Phospholipid Scramblase 1 as a Biomarker and Determination of Its Prognostic Value for Colorectal Cancer. Molecular Medicine. 2011. 17(1-2):41-47.

  3. Fan C.W., Chan C.C., Chen K.T., Huang Y.S., Han C.L., Chen Y.J., Yu J.S., Chang Y.S., Kuo Y.B., Chan E.C*. Identification of SEC61b and its autoantibody as biomarkers for colorectal cancer. Clinica Chimica Acta. 2011. 412:887-893.

  4. Ueng, S.W.N., Yuan, L.J., Lin, S.S., Liu, S.J., Chan, E.C., Chen, K.T., Lee, M.S. In vitro and in vivo analysis of a biodegradable poly(lactide-co-glycolide) copolymer capsule and collagen composite system for antibiotics and bone cells delivery. Journal of Trauma-Injury Infection and Critical Care. 2011. 70:1503-1509.

  5. Tsao, K.C., Kuo, Y.B., Huang, C.G., Chau, S.W., Chan, E.C*. Performance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virus. Journal of Virological Methods. 2011. 173:387-389.

  6. Han,C.L.,Chen,J.S.,Chan,E.C,Wu,C.P.,Yu,K.H.,Chen,K.T.,Tsou,C.C., Tsai,C.F., Chien,C.W., Kuo,Y.B., Lin,P.Y., Yu,J.S., Hsueh,C., Chen,M.C., Chan,C.C., Chang,Y.S., Chen, Y.J. An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer. Molecular & Cellular Proteomics. 2011. 10: 10.1074/mcp.M110.003087,1-15. Co-first author.

  7. Kuo YB, Chao M, Lee YH, Yeh CT, Chan EC. New enzyme-linked immunosorbent assay for

detection of antibodies against hepatitis delta virus using a hepatitis delta antigen derived from a Taiwanese clone and comparison to the Abbott radioimmunoassay. Clin Vaccine Immunol. 2012 May;19(5):817-9.

  1. Chang PY, Kuo YB, Wu TL, Liao CT, Sun YC, Yen TC, Chan EC. Association and prognostic value of serum inflammation markers in patients with leukoplakia and oral cavity cancer. Clin Chem Lab Med. 2013 Jun;51(6):1291-300.

  2. Kuo YB, Chen JS, Fan CW, Li YS, Chan EC. Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer. Clin Chim Acta. 2014 Jun 10;433:284-9.

  3. Chen CY, Chen JS, Chou YP, Kuo YB, Fan CW, Chan EC. Antibody against N-terminal domain of phospholipid scramblase 1 induces apoptosis in colorectal cancer cells through the intrinsic apoptotic pathway. Chem Biol Drug Des. 2014 Jul;84(1):36-43.

  4. Kuo YB, Li YS, Chan EC. Rapid identification of HPV 16 and 18 by multiplex nested PCR-immunochromatographic test. J Virol Methods. 2015 Feb;212:8-11.

  5. Chang PY, Chen CC, Chang YS, Tsai WS, You JF, Lin GP, Chen TW, Chen JS, Chan EC. MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection. Oncotarget. 2016 Mar 1;7(9):10663-75.

  6. Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. Gastroenterology. 2016 Mar;150(3):659-671.

  7. Chang PY, Chen JS, Chang NC, Chang SC, Wang MC, Tsai SH, Wen YH, Tsai WS, Chan EC2,3, Lu JJ. NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing. Oncotarget. 2016 Jun 21;7(25):37566-37580.

  8. Lu YC, Chang JT, Chan EC, Chao YK, Yeh TS, Chen JS, Cheng AJ. miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers. J Cancer. 2016 Mar 20;7(6):650-5.

  9. Hsu YH, Lin CT, Yu YH, Chou YC, Liu SJ, Chan EC. Dual delivery of active antibactericidal agents and bone morphogenetic protein at sustainable high concentrations using biodegradable sheath-core-structured drug-eluting nanofibers. Int J Nanomedicine. 2016 Aug 17;11:3927-37.

  10. Wu RS, Hong JJ, Wu JF, Yan S, Wu D, Liu N, Liu QF, Wu QW, Xie YY, Liu YJ, Zheng ZZ, Chan EC, Zhang ZM, Li BA. OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis. Oncotarget. 2017 Jun 13;8(24):39401-39416.

  11. Fan CW, Kuo YB, Lin GP, Chen SM, Chang SH, Li BA, Chan EC. Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer. Clin Chim Acta. 2017 Dec;475:157-163.

  12. Chou YC, Lee D, Chang TM, Hsu YH, Yu YH, Chan EC, Liu SJ. Combination of a biodegradable three-dimensional (3D) - printed cage for mechanical support and nanofibrous membranes for sustainable release of antimicrobial agents for treating the femoral metaphyseal comminuted fracture. J Mech Behav Biomed Mater. 2017 Aug;72:209-218.

Conference presentations

  1. Chan,E.C., Becvar, J.E. 1984. May 15-19. Kinetics studies on the bacterial bioluminecence. ACS annual meetig. Albuquerque, NM. USA

  1. Chan, E.C., Ueng, P., Chen., L.F. 1987. May 14-18. Limiting factor of D-xylose fermentation by Schizosaccharomyces pombe. The 9th symposium on the Biotechnology for fuels and chemicals. Boulder, CO.USA

  1. Chan, E.C., Ueng, P. 1988 May 15-19. D-Xylose fermentation by the transformed Schizosaccharomyces pombe.  The 10th symposium on the Biotechnology for fuels and chemicals. Gatlinburg, TN.USA

  1. Chan, E.C., 1994. March 12-13. Olfactory biosensor on the assistance of diagnosis of Helicobacter pylori-infected ulcer.  The 9th Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Lin, S.H. 1994, March 12-13. Development of C1q-like peptide for using in ELISA kits. The 9th Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C. 1994. Sep. 25. Immuno-diagnostic kit for Helicobacter pylori.  The 1994 Joint Meeting of the Chinese Society of Microbiology and Immunology.

  1. Chan, E.C., Lai, C.Z. 1995. March 25-26. Development of a diagnostic kit for Helicobacter pylori: Evaluation of the officiency for detecting Helicobacter pylori antibody in serum.The 10th Joint Conference of Biomedical Sciences. Taipei. Taiwan.

  1. Chan,E.C., Young, C.C. 1995. March 25-26. Expression and purification of lysostaphin. The 10 Joint Conference of Biomedical Sciences. Taipei. Taiwan

  1. Chan, E.C., Lai, C.Z. 1995 March 25-26. Cloning and secreting of a antigenicitive fragment from cytotosin associate gene of Helicobacter pylori with the lysostaphin signal sequence. The 10th Joint Conference of Biomedical Sciences. Taipei. Taiwan.

  1. Chan, E.C., Lin, Y.L. 1995. March 25-26. Identification of phospholipase of Helicobacter pylori cultured in different media. The 10th Joint Conference of Biomedical Conference. Taipei. Taiwan.

  1. Chan, E.C., Lin, Y.L. 1995 July 7-9. The sphingomyelinase acitvity of Helicobacter pylori. The 8th International Workshop on Gastroduodenal Pathology & Helicobacter pylori. Edinburgh. England.

  1. Chan, E.C. 1995. Nov. 4. The application of complement C1q in immunodiagnostic reagents. The Workshop of Immunochemistry analysis. Held by ROC Clinical Biochemistry Association. Taipei, Taiwan.

  1. Chan, E.C., Fu, C.C. 1996. April 13-14. Urea quantification by utilizing Helicobacter pylori cells and a pH indicator. The 11th Joint Conference of Biomedical Sciences. Taipei. Taiwan.

  1. Chan, E.C., Lin, Y.L. 1996. Oct. 16-19. The signal transduction pathway and pepsinogen secretion in Helicobacter pylori stimulated human gastric cells. The 9th International Workshop on Gastroduodenal Pathology & Helicobacter pylori. Copenhagen, Danmark.

  1. Chan, E.C., Lin, C.W., Chang, A.C., Pan, M.R.. 1997. April 19-20. Development of C1q like peptide for using as an universal tracer in immunoassay.  The 12th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Lin, Y.H., Chen, K.T. 1997. April 19-20. Vacuolating toxin from Helicobacter pylori activates cellular signaling and pepsinogen secretion in human gastric adenocarcinoma cells.  The 12th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Chen, K.T., Leu, M.Y., Shu, K.C., Fan H.A. 1997. April 19-20. Iedntification of novel genes that are differentially expressed in human colorectal carcinoma.  The 12th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Wan, L.., Chang, A.C., Lin, Y.H.. 1997. April 19-20. Helicobacter pylori induces genes expression in human gastric cells identified by mRNA differential display.  The 12th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Cheng, S.P., Chang, A.C. 1998. April 18-19. Development of a piezoelectric immunosensor for the detection of anti-Helicobacter pylori antibodies. The 13th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Cheng, C.C., Liu, C.S., Lin, Y.H. 1998. April 18-19. Sphingomyelinase activity of Helicobacter pylori. The 13th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chan, E.C., Hsu, K.C., Fan H.A. 1998. June 14-17. Identification of novel genes that are differentially expressed in human colorectal tumor tissue. The 15th International Conference on Human Tumor Markers “Clinical Cancer Genetics and Biological Therapies” Lugano

  1. Y.C. Tseng, K.T. Chen, E.C. Chan. 2006 March. The study of detecting influenza virus with electrochemical biosensor. The 21th Joint Annual Conference of Biomedical Sciences.Taipei, Taiwan.

  1. Jinn-Yuan Hsu, Err-Cheng Chan. 2006 March. The study of in vitro diagnostic method for colorectal cancer and lung cancer with survivin. The 21th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. M.Y. Kang, K.T. Chen, Y.H. Chen, D.R. Kang, E.C. Chan. 2007 March.a survey of the humoral immune response of colorectal cancer patients to a panel of human tumor antigens. The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Y.S. Huang, K.T. Chen, D. R. Kang, E.C. Chan. 2007 March. detection of plasma homocysteine by using an in vitro diagnostic method for cardiovascular diseases. The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan..

  1. K.T. Chen, Y.C. Chen, M.Y. Yang, D. R. Kang, E.C. Chan. 2007 March. specific proteins from mycobacterium tuberculosis in clinical diagnostic application. The 22th Joint Annual Conference of Biomedical Sciences. Taipei, Taiwan.

  1. Chen CY, Chen KY, Tsai KN, Kuo YB,Tsai CH,Wang JT, Chan EC. 2008 March.Study of the apoptosis-related pathway induced by CFP-10/ESAT-6 complex from Mycobacterium tuberculosis on normal lung cell(WI-38).The 23nd Joint Annual Conference of Biomedical Sciences.Taipei, Taiwan.

  1. Kuo YB, Chang CA, Tsai CH, Chen KY, Chen CY, Wang JT, Chan EC.The cytotoxic effects of cigarette smoke extract on lung alveolar cell line and serum autoantibodies screening of COPD patients. The 23nd Joint Annual Conference of Biomedical Sciences.Taipei, Taiwan.

  1. Fan, W.C., Chen, K.T., Kuo, Y.B., Huang, Y.S., Chen, C.Y., Hung, J.P., Wang,J.T., Chen, C., Chan, E.C. 2009 March. Development of Immunoassays by Using Survivin Antigen and Antibody for Screening Cancer Patients. The 24nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. Chen, C., Chen, K.T., Kuo, Y.B., Chen, C.Y., Hung, J.P., Huang, Y.S., Wang, J.T.,Fan, W.C., Chan, E.C. 2009 March. Development of an ELISA for Detection Colorectal Cancer with Specific Panel of Antibodies. The 24nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. Wang, J.T., Chen, K.T., Kuo, Y.B., Chen, C.Y., Hung, J.P., Huang, Y.S., Fan, W.C.,Chen, C., Chan, E.C. 2009 March. Development of an ELISA for Detection of Human Colorectal Cancer Antibodies Based on Recombinant Preteins. The 24nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. 陳俊宇，陳桂添，蔡昆男，郭永斌，詹爾昌。2010 March. Study of the Apoptosis-Related Pathway Induced by CFP-10/ESAT-6 Complex from Mycovacterium tuberculosis on WI-38 cells. The 25nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. 洪瑞萍，陳桂添，郭永斌，黃雅淑，陳俊宇，陳臻，陳業皓，詹爾昌。2010 March. Identification of Phospholipid Scramblase 1 as a Serological Marker for Colorectal Cancer. The 25nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. 李奇峰，郭永斌，吳耀光，謝孟哲，陳桂添，張正，詹爾昌。2010 March. Identification of Autoantibody Againat Alpha-Enolase in Serum of Patients with Chronic Obstructive Pulmonary Disease. The 25nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. 呂宗憲，郭永斌，吳耀光，謝孟哲，陳桂添，張正，詹爾昌。2010 March. Serum-induced Cytotoxicity against Primary Human Pulmonary Alveolar Epithelial Cells in Patients with COPD. The 25nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. 彭建慈，郭永斌，駱紀東，張正，詹爾昌。2010 March. Cigarette Smoking Extract Modulates TLRs Expression on Human Neutrophil. The 25nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. 陳業皓，陳桂添，郭永斌，陳俊宇，黃雅淑，洪瑞萍，陳臻，詹爾昌。2010 March. Development of an In Vitro Diagnostic Method for colorectal cancer by Measuring the Concentration of Stomatin-like Protein 2 in Patients’ Sera. The 25nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

  1. Jinn-Shiun Chen, Kuei-Tien Chen, Chung-Wei Fan, Chia-Li Han,Yu-ju Chen, Jau-Song Yu,Yu-Sun Chang, Err-cheng Chan. Comparison of proteomic profiles in membrane fractions between human colorectal normal and cancer tissues by using gel-assisted digestion and iTRAQ labeling mass spectrometry. 2nd CGMH International Symposium on Disease Proteomics, Taoyuan, Taiwan.

智慧財產權及應用成果

專利名稱

國別

專利號碼

發明人

專利權人

期間

染色體之目標基因突變方法

中華民國

67905

陳華儀、詹爾昌

生物技術開發中心

94/7/11~//

藉由離子交換樹酯排代色層分析法從發酵液中分離色氨酸之方法

中華民國

74319

王正仁、詹爾昌、牟敦剛

生物技術開發中心

95/10/21~//

發酵法生產色氨酸之基因工程菌

日本

蔡秀蘭、詹爾昌

生物技術開發中心

/7/11~//

基因重組菌直接發酵法生產色氨酸

中華民國

74114

蔡秀蘭、詹爾昌

生物技術開發中心

95/10/1~99/

12/31

 

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