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自由基暨粒線體醫學實驗室_論文發表 Publications

 
 
 
       更新日期 : 2023.07.07
 

<1>  Journal Articles

    1. HC Yen, TD Oberley, S Vichitbandha, YS Ho, and DK St. Clair*. 1996 September. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. The Journal of Clinical Investigation, 98, 1253-1260. [SCI] 
    2. HC Yen and DK St. Clair*. 1997 June. Transgenic and knockout mice in the study of superoxide dismutases.  Journal of Biomedical and Laboratory Sciences, 9, 40-54.
    3. JN Keller, MS Kindy, FW Holtsberg, DK St. Clair, HC Yen, A Germeyer, SM Steiner, AJ Bruce-Keller, JB Hutchins, and MP Mattson*.1998 January.  Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduced ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. Journal of Neuroscience, 18, 687-697. [SCI] 
    4. HJ Majima, TD Oberley, K Furukawa, MP Mattson, HC Yen, LI Szweda, and DK St. Clair*. 1998 April. Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death.  Journal of Biological Chemistry, 273, 8217-8224.  [SCI]
    5. P Klivenyi, DK St. Clair, M Wermer, HC Yen, TD Oberley, L Yang, and MF Beal*. 1998 October. Manganese superoxide dismutase overexpression attenuates MPTP-induced toxicity.  Neurobiology of Disease, 5, 253-259.  [SCI]
    6. HC Yen, TD Oberley, CG Gairola, LI Szweda, and DK St. Clair*. 1999 February.  Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice.  Archives of Biochemistry and Biophysics, 362, 59-66.   {SCI] 
    7. W Ibrahim, US Lee, HC Yen, DK St. Clair, and CK Chow*. 2000 March.  Antioxidant and oxidative status in tissues of manganese superoxide dismutase transgenic mice.  Free Radical Biology & Medicine, 28: 397-400.  [SCI]
    8. I Trounce, J Schmiedel, HC Yen, S Hosseini, MD Brown, JJ Olsen, and DC Wallace*. 2000 May. Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.  Nucleic Acids Research, 28, 2164-2170.  [SCI]
    9. HC Yen*, HS Cheng, YT Hsu, HJ Ho, CY Nien, and YS Lee. 2001 July. Effects of age and health status on levels of urinary 15-F2t-isoprostane. Journal of Biomedical and Laboratory Sciences, 13: 24-28.
    10.  Y Zhao, Y Xue, TD Oberley, KK Kiningham, SM Lin, HC Yen, H Majima, J Hines and DK St. Clair*. 2001 August.  Overexpression of MnSOD suppresses tumor formation by modulation of AP-1 signaling in a multistage skin carcinogenesis model.  Cancer Research, 61: 6082-6088.  [SCI]
    11.  CK Chow, HC Yen, W Ibrahim, and DK St. Clair*. Manganese superoxide dismutase transgenic mice: characteristics and implications.  2002.  Methods in Enzymology, 353: 398-409.  [SCI]
    12.  HC Yen*, CY Nien, HJ Majima, CP Lee, SY Chen, JS Wei, and LC See. 2003 February.  Increase of lipid peroxidation by cisplatin in WI38 cell but not in transformed WI38 cells. Journal of Biochemical and Molecular Toxicology, 17: 39-46.  [SCI]
    13.  HC Yen* and YT Hsu. 2004 April.  Impurities from polypropylene microcentrifuge tubes as a potential source of interference in simultaneous analysis of multiple lipid-soluble antioxidants by HPLC with electrochemical detection. Clinical Chemistry and Laboratory Medicine, 42: 390-395.   [SCI] 
    14.  F Hirai, S Motoori, S Kakinuma, K Tomita, HP Indo, H Kato, T Yamaguchi, HC Yen, DK St. Clair, T Nagano, T Ozawa, H Saisho, and HJ Majima*. 2004 April. Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in human pancreatic cancer cell line, KP4. Antioxidants & Redox Signaling, 6: 523-535. [SCI]
    15.  HC Yen*, BS Chen, and YT Hsu.  2004 June.  Effect of anticoagulants and storage of coupling regent on the analysis of extracellular glutathione peroxidase in human plasma.  Journal of Biomedical and Laboratory Sciences, 16: 6-10.
    16.  HC Yen*, H-M Chang, H J Majima,, F-Y Chen, and S-H Li. 2005 April. Levels of reactive oxygen species and primary antioxidant enzymes in WI38 cells versus transformed WI38 cells following bleomycin treatment.  Free Radical Biology & Medicine, 38: 950-959. [SCI]
    17.  HC Yen*, YC Tang, FY Chen, SW Chen, and HJ Majima. 2005 June. Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. Annals of the New York Academy of Sciences, 1042: 516-522.  [SCI]
    18. Y Zhao, LM Wang, L Chaiswing, HC Yen, TD Oberley, YC Lien, SM Lin, MP Mattson, DK St. Clair*. 2006 April. Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radical Biology & Medicine, 40: 1234-1241. [SCI]
    19. CL Lin, YT Hsu, TK Lin, JD Morrow, JC Hsu, and TC Hsieh, PK Tsay, and HC Yen*.  2006 April.  Increased levels of F2-isoprostanes following aneurysmal subarachnoid hemorrhage in humans.  Free Radical Biology & Medicine, 40: 1466-1473.  [SCI]
    20. HP Indo, M Davidson, HC Yen, Y Urano, S Suenaga, K Tomita, K Nishii, M Higuchi, Y Koga, T Ozawa, HJ Majima*.  2007 February. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.  Mitochondrion, 7: 106-118.  [SCI]  
    21. BR Huang, CC Liao, WH Huang, CC Liao, WH Huang, YH Hsu, JC Hsu, HC Yen, CL Lin*. 2008 September. Prognostic factors of spontaneous intracerebral haemorrhage in haemodialysis patients and predictors of 30-day mortality.  Internal Medicine Journal, 38: 568-574.  [SCI]
    22. JS Wang*, ML Cheng, HC Yen, BS Lou and HC Liu. 2009 February. Vitamin E suppresses enhancement of factor VIII-dependent thrombin generation by systemic hypoxia. Stroke, 40: 656-659.  [SCI]
    23. HC Tsai, HC Yen, JC Hsu, and CL Lin*. Heparin-induced thrombocytopenia associated with intra-tumour haemorrhage in cavernous sinus after cardiac myxoma surgery. 2009 February.  British Journal of Neurosurgery, 23: 95-96. [SCI]
    24. 謝育萍、顏秀娟*.  氧化傷害之臨床指標:Isoprostanes  Neuroprostanes. 生物醫學, 253-67, 2009.
    25. YP Hsieh, CL Lin, AL Shiue, H Yin, JD Morrow, JC Hsu, TC Hsieh, HJ Wei, HC Yen*. 2009 September. Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans. Free Radical Biology & Medicine, 47: 814-824.  [SCI]
    26. HJ Majima*, HP Indo, K Tomita, Y Iwashita, H Suzuki, D Masuda, T Shimazu, F Tanigaki, S Umemura, S Yano, K Fukui, A Higashibata, TQ Yamazaki, M Kameyama, S Suenaga, T Sato, H-C Yen, O Gusev, T Okuda, H Matsui, T Ozawa, and N Ishioka.  2009.  Bio-assessment of risk in long-term manned space exploration-cell death factors in space radiation and/or microgravity: a review.  Biological Sciences in Space, 23: 43-53.
    27. HC Yen*.  Detection of F2-isoprostanes and F4-neuroprostanes in clinical studies. 2010 March.  Journal of Biomedical and Laboratory Sciences, 22: 1-11. 
    28. HC Yen*, WC Hsu, CL Lin, GW Chen, YH Huang. 2010 July. Advantages and considerations in the confirmation of mitochondrial DNA mutations by denaturing HPLC and pyrosequencing.  Annals of the New York Academy of Sciences, 1201: 13-20. [SCI]
    29. HJ Majima*, HP Indo, S Suenaga, T Kaneko, H Matsui, HC Yen, T Ozawa.  2011 February. Mitochondria as source of free radicals.  Frontiers of Gastrointestinal Research, 29: 12-22.
    30. HC Yen*, SH Li, HJ Majima, YH Huang, CP Chen, YC Tu, and CW Chen. 2011 June.  Up-regulation of antioxidant enzymes and coenzyme Q10 in a human oral cancer cell line with acquired bleomycin resistance.  Free Radical Research, 45: 707-716.   [SCI]
    31. HJ Majima*, HP Indo, S Suenaga, H Matsui, HC Yen, T Ozawa.  2011 July.  Mitochondria as possible pharmaceutical targets for the effects of vitamin E and its homologues in oxidative stress-related diseases.  Current Pharmaceutical Design, 17: 2190-2195.  [SCI]
    32. HC Yen*, FY Chen, SW Chen, YH Huang, YR Chen, CW Chen. 2011 September.  Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q10 in human cells. Journal of Biochemical and Molecular Toxicology, 25: 280-289.    [SCI]
    33. YK Lin, HW Chen, SH Yang, YL Leu, YH Huang, HC Yen*. 2012 February.  Protective effect of indigo naturalis extract against oxidative stress in cultured human keratinocytes.  Journal of Ethnopharmacology, 139: 893-896.  [SCI]
    34. HP Indo, O Inanami, T Koumura, S Suenaga, HC Yen, S. Kakinuma, KC Matsumoto, I Nakanishi, W St. Clair, DK St. Clair, H Matsui, R Cornette, O Guesev, T Okuda, Y Nakagawa, T Ozawa, HJ Majima*. 2012 August. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radical Research, 46: 1029-1043.  [SCI]
    35. HP Indo, I Nakanishi, K Ohkubo, HC Yen, M Nyui, S Manda, KI Matsumoto, K Fukuhara, K Anzai, N Ikota, H Matsui, Y Minamiyama, A Nakajima, H Ichikawa, S Hukuzumi, T Ozawa, C Mukai, HJ Majima*. 2013 March. Comparison of in vivo and in vitro antioxidative parameters for eleven food factors.  RSC Advances, 3: 4535-4538.  [SCI)
    36. 顏秀娟*內生性輔酶Q之淺談生物醫學, 6103-110, 2013.
    37. SW Chen, CC Liu, HC Yen*. 2013 March. Detection of suppressed maturation of the human COQ5 protein in the mitochondria following mitochondrial uncoupling by an antibody recognizing both precursor and mature forms of COQ5.  Mitochondrion, 13: 143-152.    [SCI]
    38. HC Yen*, HJ Wei, and TW Chen. 2013 July. Analytical variables affecting analysis of F2-isoprostanes and F4-neuroprostanes in human cerebrospinal fluids by gas chromatography/mass spectrometry. Biomedical Research International, 2013: Article 810915 (1-14). [SCI]
    39. HC Yen*, SL Li, WC Hsu, P Tang. 2014 March. Interference of co-amplified nuclear mitochondrial DNA sequences on the determination of human mtDNA heteroplasmy by using the SURVEYOR Nuclease and the WAVE HS system. PLOS ONE, 9: e92817 (1-18). [SCI]
    40. HC Yen*, CC Liu, CC, Kan, CS Chen, HR Wei. 2014 September. Suppression of coenzyme Q10 levels and the induction of multiple PDSS and COQ genes in human cells following oligomycin treatment.  Free Radical Research, 48: 1125-1134. [SCI]
    41. HP Indo, HC Yen*, I Nakanishi, KI Matsumoto, M Tamura, Y Nagano, H Matsui, O Gusev, R Cornette, T Okuda, Y Minamiyama, H Ichikawa, S Suenaga, M Oki, T Sato, T Ozawa, DK St.Clair, HJ Majima*. 2015 January. A mitochondrial superoxide theory for oxidative stress diseases and aging. Journal of Clinical Biochemistry and Nutrition, 56: 1-7. [SCI]
    42. HC Yen*, HJ Wei, CL Lin. 2015 July. Unresolved issues in the analysis of F2-isoprostanes, F4-neuroprostanes, isofurans, neurofurans, and F2-dihomo-isoprostanes in body fluids and tissue using gas chromatography/negative-ion chemical-ionization mass spectrometry. Free Radical Research, 49: 861-880.  [SCI; review article]
    43. HC Kuo*, HC Yen, CC Huang, WC Hsu, HJ Wei, CL Lin. 2015 October. Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease. International Journal of Neuroscience, 125: 747-754.  [SCI]
    44. HC Yen, TW Chen, TC Yang, HJ Wei, JC Hsu*, CL Lin*. 2015 December. Levels of F2-isoprostanes, F4-neuroprostanes, and total nitrate/nitrite in plasma and cerebrospinal fluid of patients with traumatic brain injury. Free Radical Research, 49: 1419-1430. [SCI]
    45. HJ Majima*, HP Indo, I Nakanishi, S Suenaga, K Matsumoto, H Matsui, Y Minamiyama, H Ichikawa, HC Yen, CL Hawkins, MJ Davies, T Ozawa, DK St. Clair. 2016 March. Chasing great paths of Helmut Sies “Oxidative Stress”. Archives of Biochemistry and Biophysics, 595, 54-60.
    46. HC Yen*, YC Liu, CC Kan, HJ Wei, SH Lee, YH Wei, YH Feng, CW Chen, CC Huang. 2016 September. Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency. Biochimica et Biophysica Acta-General Subjects, 1860: 1864-1876. [SCI]
    47. HC Yen*, CL Lin, BS Chen, CW Chen, KC Wei, ML Yang, JC Hsu, YH Hsu. Alterations of the levels of primary antioxidant enzymes in different grades of human astrocytoma tissues. Free Radical Research, 52: 856-871, 2018.  [SCI]
    48. HC Yen*, WY Yeh, SH Lee, YH Feng, SL Yang. Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q10 levels and each other’s stability. Biochim Biophys Acta-Bioenergetics, 2020:148192.  [SCI]
    49. HC Yen*, BS Chen, SL Yang, SY Wu, CW Chang, KC Wei, JC Hsu, YH Hsu, TH Yen, CL Lin*. 2022 February. Levels of coenzyme Q10 and several COQ proteins in human astrocytoma tissues are inversely correlated with malignancy. Biomolecules, 12: 336, 2022. [SCI]
    50. TH Yen, CW Chang, HR Tsai, JF Fu, HC Yen*. Immunosuppressive therapies attenuate paraquat-induced renal dysfunction by suppressing inflammatory responses and lipid peroxidation. Free Radical Biology and Medicine 191: 249-260, 2022.    [SCI]

* Corresponding author

 

 

<2>  Book Chapter 

H J Majima, H P Indo, K Tomita, S Suenaga, S Motoori, H Kato, H-C Yen, and T Ozawa.  Intracellular oxidative stress caused by ionizing radiation.  Chapter 2 in : K Singh eds. Oxidative stress, disease, and cancer.  London,: Imperial College Press; 2005 (ISBN: 1-86094-609-7).

 

 

    <3>  Patents

Country Issuing the Patent/通過專利國家 專利名稱/Patent Name

專利證

書號碼/Patent Number

專利

期限/Patent Period

U.S.A/美國 Method of producing and purifying soluble recombinant COQ5 protein and soluble recombinant COQ5 protein thereof (1) US 8,907,062 B2 2014.12.9~2032.8.31
U.S.A./美國 Method of producing and purifying soluble recombinant COQ5 protein and soluble recombinant COQ5 protein thereof (2) US 9,150,838 B2 2015.10~2033.07
Taiwan/台灣 製造及純化可溶性重組COQ5蛋白之方法及其製得的可溶性重組COQ5蛋白 (Method of producing and purifying soluble recombinant COQ5 protein and soluble recombinant COQ5 protein thereof) 發明第I472534 2015.2.11~2032.2.23
 
 
 

 

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