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更新日期 : 2023.07.07

Education

1988-1992  B.S., National Taiwan University (Taiwan)

                     College of Medicine

                     School of Medical Technology (台大醫事技術學系)

1992-1997  Ph.D., University of Kentucky (USA)

                     Graduate Center for Toxicology

                     Advisor: Dr. Daret K. St. Clair

1997 Aug-1998 Feb  Postdoctoral scholar, University of Kentucky (USA)

                                    Graduate Center for Toxicology

                                    Mentor: Dr. Daret K. St. Clair

1998 Mar-1999 Mar  Postdoctoral Fellow, Emory University (USA)

                                    Center for Molecular Medicine

                                    Mentor: Dr. Douglas C. Wallace

1. Book-Coupon Award (top 5%) at National Taiwan University (1989).

2. Certificate of the National Examination for the Professional and Skilled Person for Medical Technologist proved by Ministry of Examination, Taiwan: qualified for the exchange of licensures for being a medical technologist (1992).

3. Young Investigator Award in the 5th Annual meeting of The Oxygen Society at Washington DC, November 22, 1998.

4. Award of Excellent Research Paper in the 19th Joint Annual Conference of Biomedical Sciences awarded by Toxicology Society of Taiwan, April 10-11, 2004.

5. "Excellent Teacher Award in Student Counseling"  from Chang Gung University, September, 2009.

6. "Excellent Research Paper Award (Clinical Field)"  from Taiwan Society of Laboratory Medicine, October, 2010. 

7. "Excellent Teacher Award in Student Counseling"  from Chang Gung University, September, 2015.

(1) In Taiwan

1. The Role of Reactive Oxygen Species in Antineoplastic Agent-induced Cardiac Toxicity: A MnSOD Transgenic Mice Model. 15th Joint Annual Conference of Biomedical Sciences, March 2000, National Yong-Ming University, Taipei (invited by Taiwan Society of Toxicology).

2. Status of oxidative stress following aneurysmal subarachnoid hemorrhage. International Conference in Oxidative Damage Marker and Antioxidant Intervention in Health and Diseases, October 29-30, 2004, Chang Gung University, Taoyuan (invited by Society for Free Radical Research, Taiwan).

3. Mitochondrial, antioxidant enzymes, and apoptosis in the effect of anticancer drugs. Symposium on Mitochondria and Related Diseases, October 8, 2005, Holiday Inn Asia World, Taipei (invited by Taiwan Society of Neurology).

4. Simultaneous detection of lipid-soluble antioxidants by CoulArray HPLC. Symposium on Wellness and Free Radicals. May 13, 2006, Chang Gung Memorial Hospital, Taoyuan (invited by Society for Free Radical Research, Taiwan).

5. Effect of antimycin A on levels of coenzyme Q₁₀ and primary antioxidant enzymes in 143B versus 143B-ρ⁰ Cells. First Annual Meeting of Taiwan Society of Mitochondrial Research and Medicine, August 5, 2006, Chang Gung Memorial Hospital, Kaoshung (invited by Taiwan Society of Mitochondrial Research and Medicine).

6. Correlation of CSF F₂-isoprostanes levels with poor outcome following aneurysmal subarachnoid hemorrhage in humans. January 26, 2007, Taipei (invited by Department of Teaching and Research, Taipei Veterans General Hospital/台北榮總教研部).

7. Alterations of endogenous coenzyme Q₁₀ levels by mitochondrial dysfunction and oxidative stress and in human astrocytomas.  Conference of Taiwan Society for Mitochondrial Research and Medicine. February 16-17, 2008, Chang Gung Memorial Hospital, Keelung (invited by Taiwan Society of Mitochondrial Research and Medicine).

8. Regulation of endogenous coenzyme Q₁₀ in response to oxidative stress and mitochondrial dysfunction.  January 8, 2009, Taipei (invited by Department of Pathology, Mackay Memorial Hospital/馬偕紀念 醫院病理科).

9. Mitochondrial DNA and Medical Research. March 23, 2009, Taipei (Invited by Investigation Bureau, Ministry of Justice/法務部調查局).
    

10. F₂-isoprostanes and F₄-neurprostanes: a specific markers of oxidative damage and the clinical application. May 26, 2009, Taoyuan (Invited by Saint Paul's Hospital/財團法人天主教聖保祿修女會醫院).

11. Features of human mitochondrial DNA and its mutation detections. Workshop in DNA Identification. September 25, 2009, Central Police University/ 中央警察大學, Taoyuan (Invited by Taiwan Academy of Forensic Sciences/ 中華民國鑑識學會).

12. F₂-isoprostanes and F₄-neuroprostanes in clinical studies.  台大醫技系55週年系慶暨先導型轉譯醫學研討會. February 26, 2011, National Taiwan University, Taipei, Taiwan (invited by Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University).

13. Elevated levels of F₂-isoprostanes and F₄-neuroprostanes in plasma and cerebrospinal fluid of patients with traumatic brain injury.  Meeting of the Society of Free Radical Research-Taiwan, October 20, 2012, Taipei, Taiwan.

14. Up-regulation of coenzyme Q₁₀ levels and expression of COQ genes in the cybrid with pathogenic mtDNA T8993G mutation. 7^th International Symposium on Genomic Medicine of Changhua Christian Hospital and Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine, October 26-27, 2012, Changhua and Taichung, Taiwan.

15. Regulation of coenzyme Q₁₀ levels and expression of PDSS and COQ genes in human cells in response to mitochondrial and oxidatve stresses. Biennial Meeting of Society for Free Radical Research Asia. Oct 16-19, 2013, Taoyuan, Taiwan.

16. Roles of the human COQ5 protein in the alterations of coenzyme Q₁₀ levels under conditions of mitochondrial dysfunction and oxidative stress. 10^th International Symposium of Genomic Medicine of Changhua Christian Hospital and Meeting of Taiwan Society for Mitochondrial Research and Medicine, September 24-25, 2016, Changhua, Taiwan.

17. F₂-isoprostanes and F₄-neuroprostanes: Golden markers for clinical research. 10^th International Symposium of Genomic Medicine of Changhua Christian Hospital and Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine, June 29-30, 2018, Changhua, Taiwan. 

18. Characterization on various PDSS and COQ proteins for biosynthesis of coenzyme Q₁₀ in human cells. Annual Meeting ofTaiwan Society for Mitochondrial Research and Medicine, November 9, 2019, National Taiwan University College of Medicine, Taipei, Taiwan.

(2) Outside Taiwan

1. The Studies of Oxidative Stress or Antioxidant Enzymes for Two Human Diseases in Neurosurgery : Aneurysmal Subarachnoid Hemorrhage and Astrocytoma. November 24, 2008, Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA (invited by University of Kentucky).
2. Correlation of F₂-isoprostanes and F₄-neuroprostanes levels in cerebrospinal fluid with clinical severity of patients following aneurysmal subarachnoid hemorrhage.  Society for Free Radical Research (SFRR) International's Free Radical School in Japan 2009, September 2-6, 2009, Niigata, Japan (invited by Society for Free Radical Search Japan).
3. Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q₁₀ in human cells. The 7^th Conference of the Asian Society for Mitochondrial Research and Medicine (ASMRM)/International Conference on Mitochondria, Life and Intervention 2010. December 15-18, 2010, Fukuoka Internal Congress Center, Fukuoka, Japan (invited by ASMRM/Japanese Society of Mitochondrial Research and Medicine).
4. F₂-isoprostanes and F₄-neuroprostanes in non-traumatic subarachnoid hemorrhage in humans and rats.  Joint Meetings of the 5th Biennial Meeting of the Society for Free Radical Research –Asia (SFRR-Asia) and the 8th Conference of the ASMRM, August 31-Sepetember 4, 2011, Kagoshima, Japan (invited by SFFR-Asia and ASMRM).

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