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何鴻耀 教授

何 鴻 耀 (Hung-Yao Ho)
何鴻耀

學歷

國防大學生命科學博士

任課科目

組織工程概論、幹細胞生物學

研究專長

生物化學、分子細胞生物學及組織工程相關技術

辦公室分機

3318

實驗室分機

5998

個人網頁

自由基生物學暨氧化還原體學研究室

E-mail

hoh01@mail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

1. 研究氧化壓力與感染性疾病之關係

      宿主因素影響病原體的感染性及致病性，然而氧化還原狀態為宿主因素之一。我們的初步研究結果顯示：宿主氧化還原態若偏向氧化態時，腸病毒的複製及所引至之細胞病變效應即加劇。粒線體狀態在病毒感染時呈異常。目前，我們使用分子技術、動物模式結合蛋白質體學，探討其機轉。感染模型上建立腸病毒71型口餵感染模型。另外，結合傳統中醫藥方，發現降低宿主感染病毒時的氧化壓力能進一步降低其病毒致病率。

2. 研究粒線體與氧化壓力在癌症發生之角色

      粒線體被認為是活性氧分子主要來源；亦是能量產生及其它生理過程如細胞淍亡之調控者。我們的初步研究結果顯示：粒線體狀態與癌細胞生長密不可分。目前，我們使用分子技術及動物模式，結合轉譯體和代謝體學，探討其機轉。同時，我們使用RNA干擾技術，研究粒線體及氧化壓力對癌症發生之角色。

3. 研究胰島代謝訊息傳遞在第二型糖尿病病理角色

        胰島β細胞能分泌胰島素，為調節體內血糖之平衡中不可或缺的角色。β細胞仰賴代謝路徑以耦合胰島素分泌，此即所謂代謝訊息傳遞(Metabolic signaling)，代謝異常發生時可以影響胰島素分泌。第二型糖尿病發病過程中與β細胞功能息息相關。目前，利用分子技術及動物模式結合代謝質體學，深入探討β細胞的代謝訊息傳遞及胰島的代謝異常如何引發糖尿病的機轉。

實驗室成員

        博士學生: 2人; 碩士學生: 2人; 大學部: 2人; 研究助理: 2人
已畢業博士: 2人; 碩士: 11人 (統計於2007-2018年)

論文與著作(Publication)

最近五年所發表論文：

  1. Chen SG, Leu YL, Cheng ML, Ting SC, Liu CC, Wang SD, Yang CH, Hung CY, Sakurai H, Chen KH, Ho HY. Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific Reports.2017; 7(1):12264. (SCI)

  2. Ho HY, Lin YT, Lin G, Wu PR, Cheng ML. Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation. Redox Biology. 2017;12:916-928. (SCI)

  3. Tang HY, Ho HY, Chiu DT, Huang CY, Cheng ML, Chen CM. Alterations of plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre syndrome. Clinica Chimica Acta. 2017; 470:75-80. (SCI)

  4. Chen SG, Cheng ML, Chen KH, Horng JT, Liu CC, Wang SM, Sakurai H, Leu YL, Wang SD, Ho HY. Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Scientific Reports. 2017; 7(1):935. (SCI)

  5. Tang HY, Wang CH, Ho HY, Wu PT, Hung CL, Huang CY, Wu PR, Yeh YH, Cheng ML. Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. Redox Biology.2017;14:499-508. (SCI)

  6. Cheng ML, Chi LM, Wu PR, Ho HY. Dehydroepiandrosterone-induced changes in mitochondrial proteins contribute to phenotypic alterations in hepatoma cells. Biochemical Pharmacology.2016;117:20-34. (SCI)

  7. Wu YH, Chiu DT, Lin HR, Tang HY, Cheng ML, Ho HY. Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses. 2016;7:6689-6706. (SCI)

  8. Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G, Jiang G, Jiang T, Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H, Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J, Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang G J, Kendler K, Flint J. Molecular signatures of major depression. Current Biology.2015; 25(9):1146-1156. (SCI)

  9. Cheng ML, Wang CH, Shiao MS, Liu MH, Huang YY, Huang CY, Mao CT, Lin JF, Ho HY, Yang NI. Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure Diagnostic and Prognostic Value of Metabolomics. Journal of The American College of Cardiology.2015; 65:1509-1520. (SCI)

  10. Yang HC, Cheng ML, Hua YS, Wu YH, Lin HR, Liu HY, Ho HY, Chiu DTY. Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway. Journal of Inflammation-London.2015;12:34. (SCI)

  11. Tang HY, Ho HY, Wu PW, Chen SH, Kuypers FA, Cheng ML, Chiu DTY. Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance. Antioxidants & Redox Signaling.2015; 22:744-759. (SCI)

  12. Cheng ML, Weng SF, Kuo CH, Ho HY. Enterovirus 71 induces mitochondrial reactive oxygen species generation that is required for efficient replication. PLoS ONE .2014; 9 (11): e113234. (SCI)

  13. Ho HY , Cheng ML, Chiu DTY. Glucose-6-phosphate dehydrogenase – beyond the realm of red cell biology. Free Radical Research. 2014; 48:1028-1048. (SCI)

  14. Hsieh YT, Lin MH, Ho HY, Chen LC, Chen CC, Shu JC. Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Epithelial Cells Are Less Tolerant to Infection by Staphylococcus aureus. PLoS One.2013; 8(11):e79566. (SCI)

  15. Cheng ML, Ho HY, Lin HY, Lai YC, Chiu DTY. Effective NET Formation in Neutrophils from Individuals with G6PD Taiwan-Hakka is Associated with Enhanced NADP+ Biosynthesis. Free Radical Research.2013; 47:699-709. (SCI)

  16. Yang HC, Chen TL, Wu YH, Cheng KP, Lin Y H, Cheng ML, Ho HY, Lo SJ, Chiu DTY. Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death & Disease.2013; 4:e616. (SCI)

  17. Ho HY, Cheng ML, Shiao MS, Chiu DTY. Characterization of Global Metabolic Responses of G6PD-Deficient Hepatoma Cells to Diamide-Induced Oxidative Stress. Free Radical Biology & Medicine.2013; 54:71-84. (SCI)

 

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