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沈家瑞 教授/主任

沈 家 瑞 (Chia-Rui Shen)

沈家瑞

Education

(學歷)

Ph.D. 1998 - Department of Pathology and Microbiology, Faculty of Medicine, University of Bristol, United Kingdom   英國布里斯托大學病理與微生物學系博士

B.Sc. 1993 - Department of Medical Technology, College of Medicine, National Cheng Kung University成功大學醫事技術學系學士

研究專長

免疫療法、醫學檢驗、疫苗發展、分子影像

Telephone

(電話):

03-2118800 ext 5200

Fax number (傳真):

03-2118698

E-mail

crshen@mail.cgu.edu.tw

Training and working experience (專業工作經歷)

Aug2021- present：Professor, Center of Molecular and Clinical Immunology, Chang Gung University長庚大學分子臨床免疫中心教授

Feb2019- Jun2019：台灣人工智慧學校北區第四期經理人班結業

Aug2018- present：Chair/Professor, Division of Biotechnology, Graduate off Biomedical t Science, Chang Gung University長庚大學生物醫學研究所生物技術組教授兼組主任

Aug2018- present：Chair/Professor, Department of Medical Biotechnology and Laboratory Science, Chang Gung University長庚大學醫學生物技術暨檢驗學系教授兼系主任

Jan2016 – present：Associate Researcher, Department of Ophthalmology, Linkou Chang Gung Memorial Hospital 林口長庚醫院眼科部視網膜科副研究員

Jul2013 - Sep2013：Visiting Scholar, Genomic and Proteomic Center, Academia Sinica中央研究院基因體中心訪問研究學人

Aug2010 - Jul2018：Associate Professor, Department of Medical Biotechnology and Laboratory Science, Chang Gung University長庚大學醫學生物技術暨檢驗學系副教授

Dec2006 - Jan2007：Visiting Scholar, Department of Radiology, Washington University in St. Louis, USA 美國華盛頓大學聖路易校區放射學系訪問學者

Jul2003 – present：考選部醫師中醫師醫檢師國家考試命題及審題委員

Feb2000 - Jul2010：Assistant Professor, Department of Medical Biotechnology and Laboratory Science (Department of Medical Technology), Chang Gung University長庚大學醫學生物技術暨檢驗學系助理教授

Sep1998 - Feb2000：Postdoctoral fellow, Institute of Biomedical Science, Academia Sinica 中央研究院生物醫學研究所博士後研究學者

Aug1993 - Jul1994：Teaching Assistant, Department of Medical Technology, College of Medicine, National Cheng Kung University成功大學醫事技術學系專任助教

Industrial experience (產學合作)

Jul. 2021- present    鴻洺科技公司

Jun. 2021- present   凌越生醫公司

Sep.2020- present   台灣花卉生技公司

Jun.2018 - Aug 2018 全崴生技公司

Jan.2018 - present 聖川實業公司

Jun.2017 - May2018   芯生代生物科技公司

Aug.2006 - Jun.2007   昕穎生物科技公司

Dec.2002 - May2003   遠東生物科技公司

Professional Qualification or Courses (專業證照)

輻射安全防護證書(2012)

人體試驗主持人考試及格證書(2008)

流式細胞分選儀FACSAria操作證書 (2007)

有機溶劑作業主管安全衛生教育訓練班第465期結業證書(2005)

操作γ射線設備Gamma Cell 3000 serial #296安全訓練證書(2004)

操作人員輻射安全訓練合格證書 (2004)

香港大學問題導向學習訓練營結業證書(2001, 2002)

實驗動物飼養管理合格證書 (2001)

醫事檢驗師執照 (1993)

Membership (專業學會)

American Association for the Advancement of Science (AAAS)

American Chemical Society (ACS)

British Society of Immunology (BSI)

The Federation of Clinical Immunology Societies (FOCIS)

中華民國醫事檢驗學會

中華民國免疫學會 (理事2012-2018)

中華民國細胞與分子生物學學會

中華民國台灣人工智慧應用發展協會 (理事2019- present)

台灣幾丁質幾丁聚醣學會 (理事2008- present)

台灣女科技人學會

台灣生物技術與生化工程學會 (原中華生化工程學會)

Honors and Awards (獎項)

2018科技部106年度大專學生研究計畫研究創作獎(擔任指導老師)

2017科技部105年度大專學生研究計畫研究創作獎(擔任指導老師)

2018醫檢學會107年度學生論壇第一名(擔任指導老師, 與郭瑞琳、溫巧尼共同指導)

2015長庚大學104年度優良教師教學獎

Book and Book Chapter:

  1. 藥理學原理：以病態生理學為基礎的藥物治療(Principles of Pharmacology:The Pathophysiologic Basis of Drug Therapy, 3/e)/ Golan D.E et al. 原著；沈家瑞等編譯(2015)/藝軒出版社 (ISBN 978-95-76169-98-4)
  2. Advances in Chitin Science- vol XII, p196-199. (2010) Published by FEQ-UNICAMP , Brazil (ISBN978-85-64131-00-2)
  3. 臨床血清免疫學/Mary Louis Turgeon 原著; 郭永斌等編譯; 沈家瑞等審閱(2004)/合記出版社
  4. Shen, CR (1998) T-cell specificity in autoimmune haemolytic anaemia. Ph.D. thesis, University of Bristol, University of Bristol, UK.
  5. Elson, CJ, Shen, CR (1998) Anemia, autoimmune hemolytic in experimental model. In Encyclopedia of Immunology (p.91-93), 2nd Ed. Edited by Roitt, I.M. and Delves, P.J. Arnold.

Patents:

  1. 2015利用幾丁質引發之免疫反應檢測過敏性氣喘病人之檢驗方法。中華民國發明專利第I479152號。
  2. 2015 A Chitin-induced Immune Response Based Method for Diagnosing Allergic Asthma in Patients. USA Patent US9,005,899.
  3. 2012短片段干擾RNA(siRNA)核苷酸及其醫藥組合物及用途。中華民國發明專利第I378800號。
  4. 2010幾丁質酵素的快速且多樣化定性試劑組與方法。中華民國發明專利第I322889號。
  5. 2010 Development of asthma therapy with rAAV-mediated AMCase shRNA. USA Patent US 7,851,616.
  6. 2009單離之幾丁質水解蛋白質、DNA、重組載體、重組幾丁質水解蛋白質以及表現系統。中華民國發明專利第I314557號。

論文與著作(Publication)

Selected publications (近十年)

  1. Shen CR (correspondence), Juang JH, Tsai ZT, Wu ST, Tsai FY, Wang JJ, Yen TC. Preparation, characterization and application of superparamagnetic iron oxide encapsulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride. Carbohydr Polym 2011 Mar; 84(1): 781- 787. Epub 2010 Aug. SCI=9.381 (CHEMISTRY, APPLIED, 5.26%)
  2. Lee MH, Chang JT, Yu FW, Shen CR (correspondence). The prevalence of IL-17–producing cells in patients with Nasopharyngeal carcinoma. J Biomed Lab Sci 2011 Mar; 23(1): 30-37.
  3. Shen CR, Wu ST, Tsai ZT, Wang JJ, Yen TC, Tsai JS, Liu CL. Characterization of the Quaternized chitosan-stabilized iron-oxide nanoparticles as a novel potential MRI contrast agent for cell tracking. Poly International 2011 Jun; 60(6): 945-950. SCI=2.990(POLYMER SCIENCE, 44.32%)
  4. Chen JK, Yeh CH, Wang LC, Liou TH, Shen CR (correspondence), Liu CL. Chitosan, the marine functional food for a potent adsorbent of humic acid. Mar Drugs 2011 Dec; 9(12):  2488-2498. SCI=5.118 (CHEMISTRY, MEDICINAL, 19.05%)
  5. Tsai JP, Lee MH, Hsu SC, Chen MY, Liu SJ, Chang JT, Liao CT, Cheng AJ, Chong P, Shen CR (correspondence), Chen HW. CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions. J Immunol 2012 Aug; 189(4): 1671-1679 SCI=5.422 (IMMUNOLOGY, 31.48%)
  6. Tsai ZT, Tsai FJ, Yang WC, Wang JF, Liu CL, Shen CR (correspondence), Yen TC. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential MRI T2 contrast agent. Mar Drugs 2012 Oct; 10(11): 2403-2414. SCI=5.118 (CHEMISTRY, MEDICINAL, 19.05%)
  7. Hsu PH, Wei KC, Huang CY, Wen CJ, Yen TC, Liu CL, Lin YT, Chen JC, Shen CR (correspondence), Liu HL. Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound. PLoS One 2013 Feb; 8(2): e57682. SCI=3.240 (MULTIDISCIPLINARY SCIENCES, 35.62%)
  8. Shen CR, Liu CL, Lee HP, Chen JK. The identification and characterization of chitotriosidase activity in pancreatin from porcine pancreas. Molecules 2013 Mar; 148(3): 2978-2987. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
  9. Shen CR, Chen HW. Fatal attraction: tumor recruitment of myeloid-derived suppressor cells is mediated by IL-17-producing CD8+ T cells. Transl Gastrointest Cancer 2013 June; 2(S1):119-122.
  10. Hwang YS, Chiang PR, Hong WH, Chiao CC, Chu IM, Hsiue GH, Shen CR (correspondence). Study in vivo intraocular biocompatibility of in situ gelation hydrogels: Poly (2-ethyl oxazoline)- block- poly (<epsilon>- caprolactone)- block- poly (2-ethyloxazoline) Copolymer, Matrigel and Pluronic F127. PLoS One 2013 July; (7): e67495. SCI=3.240 (MULTIDISCIPLINARY SCIENCES, 35.62%)
  11. Chen YS, Liu CL, Lee MH, Chen HW, Shen CR (correspondence). The role of Tc17 in cancer immunity and clinical associations. J Biomed Lab Sci 2013 Sep; 25(3): 77-83.
  12. Shen CR, Yang WC, Chen HW. The fate of regulatory T cells: survival or apoptosis. Cell Mol Immunol 2014 Jan; 11(1):11-13. doi:10.1038/cmi.2013.49. SCI=11.530 (IMMUNOLOGY, 7.41%) (NSC 101-2320-B-182-027-MY3, CMRPD3B0052, BMRP440)
  13. Chen JK, Shen CR (equal to first), Liu CL. The characteristics of chitinase expression in Aeromonas schubertii. Appl Biochem Biotechnol 2014 Apr; 172(8): 3827-3834. SCI=2.926 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 54.72%) (NSC101-2320-B-182-027-MY3)
  14. Chen YS, Shen CR (correspondence). Immune checkpoint blockade therapy: The 2014 Tang prize in biopharmaceutical science. Biomed J 2015 Jan; 38(1):5-8. SCI=4.910 (BIOCHEMISTRY&MOLECULAR BIOLOGY, 31.99%) (NSC101-2320-B-182-027-MY3, CMRPD3B0051, CMRPD1D0031)
  15. Shen CR, Juang HH, Chen HS, Yang CJ, Wu CJ, Lee MH, Hwang YS, Kuo ML, Chen YS, Chen JK, Liu CL. The correlation between chitin and acidic mammalian chitinase in animal models of allergic asthma. Int J Mol Sci. 2015 Nov; 16(11): 27371-27377. SCI=5.923 (BIOCHEMISTRY&MOLECULAR BIOLOGY, 22.56%) (CMRPD1D0032)
  16. Chang HM, Huang WY, Lin SJ, Huang WC, Shen CR, Mao WY, Shen CN. ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing. Exp Dermatol 2016 May; 25(5):355-361. SCI=3.960 (DERMATOLOGY, 27.94%)
  17. Chang FP, Cho HH, Shen CR, Ting LW, Shen CN. PDGF PDGF facilitates direct lineage reprogramming of hepatocytes to functional β-like cells induced by Pdx1 and Ngn3. Cell Transplant 2016 Oct; 25(10):1893-1909. SCI=4.064 (TRANSPLANTATION, 32.00%)
  18. Yang WC, Hwang YS, Chen YY, Liu CL, Shen CN, Hong WH, Lo SM, Shen CR (correspondence). Interleukin-4 supports the suppressive immune responses elicited by regulatory T cells. Front Immunol 2017 Nov; 8: Article 1508. SCI=7.561 (IMMUNOLOGY, 14.81%) (CMRPD1D0031-3, CMRPG3C0171, BMRP440)
  19. Lee MH, Chang TC, Liao CT, Chen YS, Kuo ML, Shen CR (correspondence). Interleukin 17 and peripheral IL-17-expressing T cells are negatively correlated with the overall survival of head and neck cancer patients. Oncotarget 2018 Jan; 9(11): 9825-9837. SCI (2016)=5.168 (ONCOLOGY, 20.28%). (CORPD1F0031, BMRP440)
  20. Shih MF, Pan KH, Liu CC, Shen CR, Cherng JY. Treatment of β-thujaplicin counteracts di(2-ethylhexyl)phthalate (DEHP)-exposed vascular smooth muscle activation, inflammation and atherosclerosis progression. Regul Toxicol Pharmacol 2018 Feb; 92:333-337. SCI=3.271 (MEDICINE, LEGAL, 17.65%)
  21. Chen YS, Hwang CH, Liu CL, Chen HS, Wu ST, Lee MH, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther 2019 Mar; 30(3):273-285. SCI=5.695 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 15.09%) (CMRPD3B0053, CORPD1F0031-3, BMRP440)
  22. Barker NM, Li YX, Lee MM, Shen CR, Krause JA, Sun SS, Lu N, Connick WB, and McMillin DR. Synthesis, luminescence, and structure of a polymorphic polyfluorinated diiodoplatinum (II) diimine complex. Inorg Chem. 2019 Aug; 58(16):10716-10724. SCI=5.165 (CHEMISTRY, INORGANIC & NUCLEAR, 11.11%)
  23. Elakkat V, Chang CC, Chen JY, Fang YC, Shen CR (correspondence), Liu LK, Lu N. The first two examples of halogen bonding with a sigma hole-donating fluorine in the Csp3–F⋯Osp3 interaction from polyfluorinated trans-dihalo-palladium(II) di-substituted pyridine complexes. Chem Commun (Camb). 2019 Nov; 55(95):14259-14262.SCI=6.222 (CHEMISTRY, MULTIDISCIPLINARY, 24.72%)(MOST108-2320B-182-032)
  24. Lin HC, Chen CY, Kao CW, Wu ST, Chen CL Shen CR, Juang JH, IM Chu. In situ gelling-polypeptide hydrogel systems for the subcutaneous transplantation of MIN6 cells. J Polym Res. 2020 Feb; 27, 64. SCI=3.097 (POLYMER SCIENCES, 40.91%)
  25. Shen CR, Chen YS, Hwang YS, Chen HJ, Liu CL. Differential bicistronic gene translation mediated by the internal ribosome entry site element of encephalomyocarditis virus. Biomed J 2020 Jun. doi:10.1016/j.bj.2020.06.006. SCI=4.910 (BIOCHEMISTRY&MOLECULAR BIOLOGY, 31.99%) (MOST105-2221-E-131-035, BMRP440, CMRPD1I0071-2)
  26. Chiu CF, Ho JH, Tessema E, Lu Y, Shen CR, Lin CW, Lu N. Short-chained platinum complex catalyzed hydrosilylation under thermomorphic conditions: heterogeneous phase separation at ice temperature.. Molecules 2021 Jan; 26(2):378. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
  27. Tessema E, Elakkat V, Chiu CF, Zheng JH, Chan KL, Shen CR, Zhang P, Lu N. Recoverable Phospha-Michael additions catalyzed by a 4-N,N-dimethylaminopyridinium saccharinate salt or a fluorous long-chained pyridine: two types of reusable base catalysts. Molecules 2021 Feb; 26(4):1159. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
  28. Tessema E, Elakkat V, Chiu CF, Tsai ZL, Chan KL, Shen CR, Su HC, Lu N. Recoverable palladium‐catalyzed carbon‐carbon bond forming reactions under thermomorphic mode: Stille and Suzuki‐Miyaura reactions. Molecules 2021 Mar; 26(5), 1414. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
  29. Juang JH, Lin HC, Chen CY, Kao CW, Chen CL, Wu ST, Lin SH, Shen CR, Wang JJ, Tsai ZT, Chu IM. Noninvasive tracking of mPEG-poly(Ala) hydrogel-embedded MIN6 cells after subcutaneous transplantation in mice. Polymers 2021 Mar; 13(6), 885. SCI=4.329 (POLYMER SCIENCE, 20.45%)
  30. Juang JH, Wang JJ, Shen CR (equal to first), Chen CY, Kao CW, Chen CL, Lin SH, Wu ST, Li WC, Tsai ZT. Magnetic resonance imaging of transplanted porcine neonatal pancreatic cell clusters labeled with chitosan-coated superparamagnetic iron oxide nanoparticles in mice. Polymers 2021 Apr; 13(8), 1238. SCI=4.329 (POLYMER SCIENCE, 20.45%)
  31. Lo SM, Hwang YS, Liu CL, Shen CN, Hong WH, Yang WC, Lee MH, Shen CR (correspondence). Inhibiting TLR7 expression in the retinal pigment epithelium suppresses experimental autoimmune uveitis. Front Immunol (in revision) 2021. SCI=7.561 (IMMUNOLOGY, 14.81%) (MOST 109-2320-B-182-037, CMRPD1I0071-2, BMRP440)
  32. Hsu LJ, Liu CL, Kuo ML, Shen CN, Shen CR (correspondence). An alternative cell therapy for cancers: induced pluripotent stem cell (iPSC)-derived natural killer cells. Biomedicines (in revision) 2021. SCI=6.081 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 14.81%) (MOST 109-2320-B-182-037, CMRPD1H0621, CMRPD1K0491, BMRP440)
  33. Juang JH, Shen CR (equal to first),Wang JJ, Wu ST, Lin SH, Chen CY, Kao CW, Chen CL, Wang YM. Exendin-4-conjugated manganese magnetism-engineered iron oxide nanoparticles as a potential magnetic resonance imaging contrast agent for tracking transplanted b-cells. (in revision) 2021.
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