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賴信志 特聘教授

  (Hsin-Chih Lai)

賴信志

學歷

英國劍橋大學病理系所博士

任課科目

大學部(臨床微生物學及實驗、生物化學)、碩士班(高等微生物及感染症學)、博士班(高等細菌學)

研究專長

腸道微生物體與宿主免疫力及疾病互動機轉 (Deciphering the Interplay between Gut Microbiome and Host Immunity and Diseases)

開發具免疫調控與發炎疾病控制的草藥生物製劑 (Discovery of Novel Bioactive Components from Traditional Chinese Herbs to Treat Inflammatory Diseases)

開發具免疫調控的益生菌與益菌元 (Discovery of Novel Probiotics and Prebiotics with Immunomodulatory Function)

生物感測器開發 (Biosensors development)

辦公室(實驗室)分機

3585

實驗室名稱

感染、發炎暨分子免疫研究室(Infection, Inflammation and Molecular Immunology Laboratory)

個人網頁

微生物相研究中心

E-mail

hclai@mail.cgu.edu.tw

研究方向及研究室特色(Lab & Research Interest)

Deciphering the Interplay between Gut Microbiome and Host Immunity and Diseases

(腸道微生物體與宿主免疫力及疾病互動機轉)

Gut microbiome has been closely linked to immune development and inflammatory disease progression in local gastrointestinal (GI) tract and systemic extra-GI regions. We mainly focus on several diseases, including gastrointestinal tract diseases (intestinal bowel disorders (IBDs) and colorectal cancer (CRC)), metabolic disorders (obesity and non-alcoholic fatty liver diseases (NAFLD)), and respiratory tract diseases (asthma and mycobacterial infection). Using established murine diseases model (SPF and Germ-free model) and metagenomics microbiota analysis, we aim to uncover the novel players from the microbial and host side in order to develop novel gut microbiota-targeting intervention strategy.
Discovery of Novel Bioactive Components from Medicinal Herbs to Treat Inflammatory Diseases

(開發具免疫調控與發炎疾病控制的草藥生物製劑)

Traditional Chinese herbal medicine, including medicinal mushrooms and plants, exerts immune-homeostatic ability of Yin-Yang effects and gut microbiota targeting ability. Based on our established in vitro screening platform and in vivo disease mouse model, we aim to uncover novel bioactive ingredients from medicinal mushrooms and herbs to counteract inflammatory diseases, including IBDs, CRC, obesity, NAFLD, and asthma. 
Discovery of Novel Probiotics and Prebiotics with Immunomodulatory Function

(開發具免疫調控的益生菌與益菌元)

Understanding the interplay between gut microbiota-host immunity in health and disease circumstances will facilitate the discovery of novel gut microbes and derived components in order to develop potential probiotics. Additionally, medicinal herbs-mediated microbiota manipulation will be beneficial for development of novel prebiotics to exploit gut microbiota against inflammatory diseases.

Biosensors development (生物感測器開發)

Labor-intensive and time-consuming procedures of clinical diagnosis of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterium (NTM) have been a problem for clinicians to make a proper treatment for patients suffering from these troublesome mycobacterial infections. In collaboration with engineers in academic and bioindustry, we aim to develop fast, simple, and accurate engineered biosensors for diagnosis of MTB and NTM in order to apply to clinical diagnosis.

榮譽

  • 榮獲2020台灣創新技術博覽會發明競賽銅牌獎。

  • 獲科技部108年度研究傑出獎。

  • 榮獲106107年度Biomedical Journal最佳論文SCI引用次數,收錄期刊引用獎。

  • 獲本校104109年度優良教師研究獎。

  • 104年度財「團法人養樂多文教基金會」特優論文獎。

  • 指導博士班學生張志榮(25)及吳宗儒(29)博士獲得王民寧優秀論文獎

  • 指導博士班學生吳宗儒獲得「第25屆肝病防治學術基因會」之「優秀論文獎」。

專利

  1. 戈氏副擬桿菌用於抑制肥胖之用途。台灣專利:I640313、中國專利:CN109419815B、美國專利:9,956,255 專利期限2018/11/11-2037/08/17

  2. 戈氏副擬桿菌用於降低胰島素抗性及提升葡萄糖耐受性之用途。台灣專利:I640314、中國專利:CN109419817B、美國專利:10,086,019 專利期限:2018/11/11-2037/08/21

  3. 戈氏副擬桿菌用於抑制脂肪肝疾病之用途。台灣專利:I636788、中國專利:CN109419814B、美國專利:10,111,915 專利期限:2018/10/01-2037/08/27

  4. 中華被毛孢多醣體用於促進胰島素敏感性之用途及其製備方法。台灣專利:I604849、中國專利:CN106236769A、美國專利:9,828,442 專利期限:2017/11/11-2035/06/10

  5. 中華被毛孢多醣體用於抑制肥胖之用途及其製備方法。台灣專利:I599362、中國專利:CN106236768B、美國專利:9,782,431 專利期限:2017/09/21-2035/06/10

  6. 中華被毛孢多醣體用於治療脂肪肝疾病之用途及其製備方法。台灣專利:I593419、中國專利:CN106236786B、美國專利:9,782,447 專利期限:    2017/08/01-2035/06/10

  7. 靈芝多醣體用於抑制脂肪肝形成之用途及其製備方法。台灣專利:I569803、中國專利:CN106389459B、美國專利:9,763,990 專利期限:2017/02/11-2035/07/26

  8. 靈芝多醣體作為抑制肥胖之用途及其製備方法。台灣專利:I543765、中國專利:CN 106188321B、美國專利:9,758,595 專利期限:2016/08/01-2035/05/24

  9. 靈芝多醣體用於促進胰島素敏感性之用途及其製備方法。台灣專利:I542355、中國專利:CN106236770B、美國專利:9,757,409 專利期限:2016/07/21-2035/06/04

  10. 從牛樟菇中分離的化合物、其製備方法及用途。台灣專利:I538671專利期限:2016/06/21-2034/07/13

  11. 使用Serratia marcescens突變菌株檢測環境污染物質之方法及包含發光基因之Serratia marcescens菌株。台灣專利:I352119專利期限:2011/11/11- 2024/12/13

  12. 基因重組載體、基因重組發光菌及其用於檢測生物抑制性物質之方法。台灣專利:I325892 專利期限:2010/06/11- 2023/12/18

  13. 檢測裝置。台灣專利:M374057專利期限:2010/02/11- 2019/09/15

技術移轉

  1. 技術名稱:肺結核檢測裝置。專利名稱:檢測裝置。授權單位:生策會。被授權:肽湛生技。合約期間:103/4-113/40

論文與著作(Publication)

 所發表論文

  1. Hsin-Chih Lai, Tzu-Lung Lin, Ting-Wen Chen, Yu-Lun Kuo, Chih-Jung Chang, Tsung-Ru Wu, Ching-Chung Shu, Ying-Huang Tsai, Simon Swift, Chia-Chen Lu*. Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide. Gut. 2022 Feb;71(2):309-321. SCI=23.059 (Gastroenterology & Hepatology 3.26%)
  2. Chia-Ming Yang, Tzung-Hai Yen, Hui-Ling Liu, Yu-Jing Lin, Po-Yen Lin, Leung Sze Tsui, Chun-Hui Chen, Yu-Ping Chen, Yu-Chieh Hsu, Chih-Hong Lo, Tsung-Ru Wu, Hsin-Chih Lai, Wei-Chun Chin, Dorota G. Pijanowska, Tsann-Long Hwang*, Chao-Sung Lai*. A real-time mirror-LAPS mini system for dynamic chemical imaging and cell acidification monitoring. Sensors and Actuators: B. Chemical. 2021 Aug; 341(2021)130003. SCI=7.46 (Instruments & Instrumentation 4.68%)
  3. Hai-Hua Chuang, Jen-Fu Hsu, Li-Pang Chuang, Cheng-Hsun Chiu, Yen-Lin Huang, Hsueh-Yu Li, Ning-Hung Chen, Yu-Shu Huang, Chun-Wei Chuang, Chung-Guei Huang , Hsin-Chih Lai and Li-Ang Lee*. Different Associations between Tonsil Microbiome, Chronic Tonsillitis, and Intermittent Hypoxemia among Obstructive Sleep Apnea Children of Different Weight Status: A Pilot Case-Control Study. Journal of Personalized Medicine. 2021 May 28;11(6):486. SCI=4.945 (Health Care Sciences & Services 13.89%)
  4. Briliant Adhi Prabowo, Agnes Purwidyantri, Bei Liu, Hsin-Chih Lai and Kou-Chen Liu*. Gold nanoparticles-assisted plasmonic enhancement for DNA detection on the graphene-based portable SPR sensor. Nanotechnology. 2021 Feb 26;32(9):095503. SCI=3.874 (Materials Science, Multidisciplinary 41.62%)
  5. Chih-Yung Chiu, Hsin-Cheng Chou, Lun-Ching Chang, Wen-Lang Fan, Michael Cong Vinh Dinh, Yu-Lun Kuo, Wen-Hung Chung, Hsin-Chih Lai, Wen-Ping Hsieh, Shih-Chi Su*. Integration of metagenomics-metabolomics reveals specific signatures and functions of airway microbiota in mite-sensitized childhood asthma. Allergy. 2020 Nov;75(11):2846-2857. SCI=13.146 (Allergy 3.57%)
  6. Hongtao Liu, Junping Zheng, Hsin-Chih Lai, Baifei Hu, Lin Zhu, Elaine Lai-Han Leung* & Hong Wei*. Microbiome technology empowers the development of traditional Chinese medicine. Science China-Life Sciences. 2020 Nov ;63(11):1759-1761. SCI=6.038  (Biology 10.75%)
  7. Ye Zhao, Congxia Lu, Huiling Wang, Qing Lin, Liangliang Cai, Fanrong Meng, Enque Biniam Tesfaye, Hsin-Chih Lai*, Chi-Meng Tzeng*. Identification of hsa-miR-1275 as a Novel Biomarker Targeting MECP2 for Human Epilepsy of Unknown Etiology. Molecular Therapy-Methods & Clinical Development. 2020 Dec; 19:398-410. SCI=6.698 (Medicine, Research & Experimental 17.86%)
  8. I-Wen Wu, Chin-Chan Lee, Heng-Jung Hsu, Chiao-Yin Sun , Yuen-Chan Chen, Kai-Jie Yang, Chi-Wei Yang, Wen-Hun Chung, Hsin-Chih Lai, Lun-Ching Chang* ,and Shih-Chi Su*. Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction. Nutrients. 2020 Sep 12; 12(9):E2799. SCI=5.717 (Nutrition & Dietetics 19.32%)
  9. Tzu-Lung Lin, Chia-Chen Lu, Wei-Fan Lai, Ting-Shu Wu, Jang-Jih Lu, Young-Mao Chen, Chi-Meng Tzeng, Hong-Tao Liu, Hong Wei, Hsin-Chih Lai*. Role of gut microbiota in identification of novel TCM-derived active metabolites. Protein Cell. 2021 May;12(5):394-410. SCI=14.87 (Cell Biology 8.72%)
  10. Tzu-Lung Lin, Chia-Chen Lu, Wei-Fan Lai, Hsin-Chih Lai*. Roles of Gut Microbiota and Sera Metabolomics in Amelioration of Diabetes and Metabolic Syndrome by Bariatric Surgery. Journal of Biomedical & Laboratory Sciences. 2020 Sep;32(3):108-116
  11. Tzu-Lung Lin, Sui-Yuan Chang, I-Shan Lee, Hui-Ling Yeh, Po-I Wu, Wei-Fan Lai, Chia-Hsiang Hsu, Chia-Chen Lu, Hsin-Chih Lai*. A Highly Efficient Ultraviolet Light C-Emitting Diodes (UVC-LED)-Based Portable Device for Elimination of SARS-CoV-2 and other Pathogenic Microbes. Journal of Biomedical & Laboratory Sciences. 2020 Dec30;32(4):191-198
  12. Tzu-Lung Lin, Chia-Chen Lu, Wei-Fan Lai, Ting-Shu Wu, Jang-Jih Lu, Young-Mao Chen, Chi-Meng Tzeng, Hong-Tao Liu, Hong Wei, Hsin-Chih Lai*. Gut Microbiota-Based Integrated Multiomics Study-The Next Generation TCM Herbology Research. Journal of Biomedical & Laboratory Sciences. 2020 Jun 30;32(2):60-75.    
  13. Chin-Chung Shu, Ming-Fang Wu, Sheng-Wei Pan, Ting-Shu Wu*, Hsin-Chih Lai*, Meng-Chih Lin. Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease. Journal of the Formosan Medical Association. 2020 May 22;S0929-6646(20)30174-1. SCI=3.282 (Medicine, General & Internal 31.36%)
  14. Tzu-Lung Lin, Chin-Chung Shu, Young-Mao Chen, Jang-Jih Lu, Ting-Shu Wu, Wei-Fan Lai, Chi-Meng Tzeng, Hsin-Chih Lai*, Chia-Chen Lu*. Like Cures Like: Pharmacological Activity of Anti-Inflammatory Lipopolysaccharides From Gut Microbiome. Frontiers in Pharmacology.2020 Apr 30;11:554. SCI=5.811 (Pharmacology & Pharmacy 14.18%)
  15. I-Wen Wu, Sheng-Siang Gao, Hsin-Cheng Chou, Huang-Yu Yang, Lun-Ching Chang, Yu-Lun Kuo, Michael Cong Vinh Dinh, Wen-Hung Chung, Chi-Wei Yang, Hsin-Chih Lai, Wen-Ping Hsieh, Shih-Chi Su*. Integrative metagenomic and metabolomic analyses reveal severity-specific signatures of gut microbiota in chronic kidney disease. Theranostics. 2020 Mar; 10(12): 5398-5411. SCI=11.556 (Medicine, Research & Experimental 6.43% )
  16. Hai-Hua Chuang, Chung-Guei Huang, Li-Pang Chuang, Yu-Shu Huang, Ning-Hung Chen, Hsueh-Yu Li, Tuan-Jen Fang, Jen-Fu Hsu, Hsin-Chih Lai, Jau-Yuan Chen and Li-Ang Lee*. Relationships Among and Predictive Values of Obesity, Inflammation Markers, and Disease Severity in Pediatric Patients with Obstructive Sleep Apnea Before and After Adenotonsillectomy. Journal of Clinical Medicine. 2020 Feb; 9(2): 579. SCI=4.242 (Medicine General Internal 23.08%)
  17. I-Wen Wu, Chan-Yu Lin, Lun-Ching Chang, Chin-Chan Lee, Chih-Yung Chiu, Heng-Jung Hsu, Chiao-Yin Sun, Yuen-Chan Chen, Yu-Lun Kuo, Chi-Wei Yang, Sheng-Siang Gao, Wen-Ping Hsieh, Wen-Hung Chung, Hsin-Chih Lai, Shih-Chi Su*. Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study.  International Journal of Biological Sciences. 2020 Jan 1;16(3):420-434. SCI=6.58 (Biochemistry & Molecular Biology 19.2%)
  18. Tzu-Lung Lin, Ching-Chung Shu, Wei-Fan Lai, Chi-Meng Tzeng, Hsin-Chih Lai*, Chia-Chen Lu*. Investiture of next generation probiotics on amelioration of diseasesStrains do matter. Medicine in Microecology 1-2 (2019 Dec) 100002
  19. Yu-Chun Lin*, Cheng Huang, Hsin-Chih Lai Revealing the ultrastructure of the membrane pores of intact Serratia marcescens cells by atomic force microscopy. Heliyon. 2019 Oct 15;5(10): e02636. SCI=0.46  (Multidisciplinary Sciences 27.78%)
  20. Ming-Fang Wu, Chin-Chung Shu, Jann-Yuan Wang, Bo-Shiun Yan, Hsin-Chih Lai, Bor-Luen Chiang, Lawrence Shih-Hsin Wu* & Chong-Jen Yu*. NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1β response and host susceptibility. Scientific Reports. 2019 Aug 29;9(1): 12534. SCI=4.379 (Multidisciplinary Sciences 23.29%)
  21. Chin-Chung Shu, Lawrence Shih-Hsin Wu, Ming-Fang Wu, Hsin-Chih Lai, Ping-Huai Wang, Shih-Lung Cheng, Jann-YuanWang, Chong-Jen Yu*. Mono- and poly-functional T cells in nontuberculous mycobacteria lung disease patients: Implications in analyzing risk of disease progression. Cytokine. 2019 Aug;120:176-185. SCI=3.861 (Biochemis & Molecular Biology 50.17%)
  22. Ya-Hui Liu, Yung-Chi Chang, Liang-Kuei Chen, Po-An Su, Wen-Chien Ko, Yau-Sheng Tsai, Yi-Hsuan Chen, Hsin-Chih Lai, Cheng-Yeu Wu, Yuan-Pin Hung and Pei-Jane Tsai*. Corrigendum: The ATP-P2X7 Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation. Frontiers in Cellular and Infection Microbiology. 2019 Jul 17;9:260. SCI=5.293 (Microbiology 24.09%)
  23. Chih-Jung Chang, Tzu-Lung Lin, Yu-Ling Tsai, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu* and Hsin-Chih Lai*. Next generation probiotics in disease amelioration. Journal of Food and Drug Analysis. 2019 Jul;27(3):615-622. SCI=6.079 (Food Science & Technology 8.16%)
  24. Tsung-Ru Wu, Chuan-Sheng Lin, Chih-Jung Chang, Tzu-Lung Lin, Jan Martel, Yun-Fei Ko, David M Ojcius, Chia-Chen Lu, John D Young* and Hsin-Chih Lai*. The gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis mycelium. Gut. 2019 Feb;68(2):248-262. SCI= 23.059 (Gastroenterology & Hepatology 3.26%)
  25. Yi-Hsing Chen,Wan-Hua Tsai, Hui-Yu Wu, Chun-Ya Chen, Wen-Ling Yeh, Ya-Hui Chen, Hui-Ying Hsu, Wei-Wei Chen, Yu-Wen Chen, Wen-Wei Chang, Tzu-Lung Lin, Hsin-Chih Lai, Yu-Hsin Lin*, and Chih-Ho Lai*. Probiotic Lactobacillus spp. act Against Helicobacter pylori-induced Inflammation. Journal of Clinical Medicine. 2019 Jan 14; 8(1): 90. SCI=4.241 (Medicine General Internal 9.68%)
  26. Probiotics, prebiotics and amelioration of diseases. Yu-Ling Tsai, Tzu-Lung Lin, Chih-Jung Chang, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu* and Hsin-Chih Lai*. Journal of Biomedical Science. 2019 Jan 4;26(1):3. SCI=8.41 (Medicine, Research & Experimental 10.71%)
  27. Ju-Hsin Chia, Ting-Shu Wu, Tsu-Lan Wu, Chyi-Liang Chen, Chih-Hsien Chuang, Lin-Hui Su, Hong-Jyun Chang, Chia-Chen Lu, An-Jing Kuo, Hsin-Chih Lai*, Cheng-Hsun Chiu*. Clostridium innocuum is a vancomycin-resistant pathogen that may cause antibiotic-associated diarrhea. Clinical Microbiology and Infection. 2018 Nov;24(11):1195-1199.    SCI=8.067 (Infectious Diseases 5.43%)
  28. Hsin-Chih Lai, Chih-Jung Chang, Chuan-Sheng Lin, Tsung-Ru Wu, Ya-Jing Hsu, Ting-Shu Wu, Jang-Jih Lu, Jan Martel, David M.Ojcius, Cheng-Lung Ku, John D. Young, and Chia-Chen Lu*. NK Cell-Derived IFN-g Protects against Non-Tuberculous Mycobacterial Lung Infection. Journal of Immunology. 2018 Sep 1;201(5):1478-1490. SCI=5.422 (Immunology 31.48%)
  29. Yi-Hung Hsiao, Yu-Ling Tsai, Chih-Jung Chang, Tzu-Lung Lin, Wei-Fan Lai, Hsin-Chih Lai, and Chia-Chen Lu*. Molecular Mechanisms in TH2 asthma. Journal of Biomedical & Laboratory Sciences 2018 Sep;30(3):33-37
  30. Chin-Chung Shu, Jann-Yuan Wang, Ming-Fang Wu, Hsin-Chih Lai, Bor-Luen Chiang, Chong-Jen Yu*. Interleukin 23/interleukin 17 axis activated by Mycobacterium avium complex (MAC) is attenuated in patients with MAC-lung disease. Tuberculosis (Edinb). 2018 May;110:7-14.   SCI=3.131 (Respiratory System 53.13%)
  31. Ya-Hui Liu, Yung-Chi Chang, Liang-Kuei Chen, Po-An Su, Wen-Chien Ko, Yau-Sheng Tsai, Yi-Hsuan Chen, Hsin-Chih Lai, Cheng-Yeu Wu, Yuan-Pin Hung, and Pei-Jane Tsai*. The ATP-P2X7 Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation. Frontiers in Cellular and Infection Microbiology. 2018 Mar 16;8:84. SCI=5.293 (Microbiology 24.09%)
  32. Tsung-Teng Huang, Ying-Wei Lan, Yun-Fei Ko, Chuan-Mu Chen, Hsin-Chih Lai, David M. Ojcius, Jan Martel, John D. Young*, Kowit-Yu Chong*.Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway. Journal of Ethnopharmacology. 2018 Jun 28;220:239-249. SCI=4.36 (Plant Sciences 13.19%)
  33. Chih-Jung Chang, Chia-Chen Lu, Chuan-Sheng Lin, Jan Martel, Yun-Fei Ko, David M. Ojcius, Tsung-Ru Wu, Yu-Huan Tsai, Jang-Jih Lu, Ta-Sen Yeh, Hsin-Chih Lai*, John D. Young*. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. International Journal of Obesity. 2018 Feb;42(2):231-243.    SCI=5.095 (Nutrition & Dietetics 25.84%)
  34. Briliant Adhi Prabowo1, Ying-Feng Chang1, Hsin-Chih Lai1, Azharul Aloma, Parthasarathi Pal, Yu-Ying Lee, Nan-Fu Chiu, Koji Hatanaka, Li-Chen Su*, Kou-Chen Liu*.Rapid screening of Mycobacterium tuberculosis complex (MTBC) in clinical samples by a modular portable biosensor. Sensors and Actuators B: Chemical. 2018 Jan ;254:742-748. SCI=7.46 (Instruments & Instrumentation 4.68%)
  35. Julieta Schachter, Jan Martel, Chuan-Sheng Lin, Chih-Jung Chang, Tsung-Ru Wu, Chia-Chen Lu, Yun-Fei Ko, Hsin-Chih Lai, David M. Ojcius, John D. Young*. Effects of obesity on depression: a role for inflammation and the gut microbiota. Brain, Behavior, and Immunity. 2018 Mar;69:1-8. SCI=7.217 (Psychiatry 10.26%)
  36. Ming-Chun Lee, Pei-Lun Sun, Tsu-Lan Wu, Li-Hsin Wang, Chih-Hsun Yang, Wen-Hung Chung, An-Jing Kuo, Tsui-Ping Liu, Jang-Jih Lu, Cheng-Hsun Chiu, Hsin-Chih Lai, Nan-Yu Chen, Jeng-How Yang, Ting-Shu Wu*. Antimicrobial resistance in Mycobacterium abscessus complex isolated from patients with skin and soft tissue infections at a tertiary teaching hospital in Taiwan. Journal of Antimicrobial Chemotherapy. 2017 Oct 1;72(10):2782-2786.   SCI=5.113 (Pharmacology & Pharmacy 8.24%)
  37. Jan Martel, Yun-Fei Ko, Jian-Ching Liau, Chien-Sheng Lee, David M. Ojcius, Hsin-Chih Lai, John D. Young*. Myths and Realities Surrounding the Mysterious Caterpillar Fungus. Trends in Biotechnology. 2017 Nov;35(11):1017-1021. SCI=19.536  (Biotechnology & Applied Microbiology 2.46%)
  38. Jan Martel, Yun-Fei Ko, David M. Ojcius, Chia-Chen Lu, Chih-Jung Chang, Chuan-Sheng Lin, Hsin-Chih Lai, John D. Young*. Immunomodulatory Properties of Plants and Mushrooms.  Trends in Pharmacological Sciences. 2017 Nov;38(11):967-981. SCI=14.819 (Pharmacology & Pharmacy 1.818%)
  39. Chia-Fong Wei, Yu-Huan Tsai, Sheng-Hui Tsai, Chuan-Sheng Lin, Chih-Jung Chang, Chia-Chen Lu, Hsiou-Chen Huang, Hsin-Chih Lai*. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochemical and Biophysical Research Communications. 2017 Jul 15;489(1):70-75. SCI=3.575   (Biophysics 41.67%)
  40. Chin-Chung Shu, Ming-Fang Wu, Jann-Yuan Wang, Hsin-Chih Lai, Li-Na Lee, Bor-Luen Chiang and Chong-Jen Yu*. Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells. Respiratory Research. 2017 Jun 26;18(1):128. SCI=3.829   (Respiratory System 31.7%)
  41. Tsung-Ru Wu, Tsung-Teng Huang, Jan Martel, Jian-Ching Liau, Chen-Yaw Chiu, Yann-Lii Leu, Wei-Ting Jian, I-Te Chang, Chia-Chen Lu, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai*, John D. Young*. Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells. Journal of Ethnopharmacology. 2017 Apr 6;201:117-122. SCI=4.36 (Plant Sciences 13.19%)
  42. Jan Martel, David Ojcius, Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Yun-Fei Ko, Shun-Fu Tseng, Hsin-Chih Lai, and John Young*. Anti-obesogenic and antidiabetic effects of plants and mushrooms. Nature Reviews Endocrinology. 2017 Mar;13(3):149-160. SCI=43.33     (Endocrinology & Metabolism 1.13%)
  43. Chin-Chung Shu, Jann-Yuan Wang, Ming-Fang Wu, Chen-Tu Wu, Hsin-Chih Lai, Li-Na Lee, Bor-Luen Chiang* & Chong-Jen Yu*. Scientific Reports. 2017 Feb 7 ;7:42004. Attenuation of lymphocyte immune responses during Mycobacterium avium complex-induced lung disease due to increasing expression of programmed death-1 on lymphocytes. SCI=4.379 (Multidisciplinary Sciences 23.29%)
  44. Chun-Hung Yang, Heng-Yuan Chang, Yi-Chuan Chen, Chia-Chen Lu, Shyh-Shyun Huang, Guan-Jhong Huang*, Hsin Chih Lai*. Ethanol extract of Phellinus merrillii protects against Diethylnitrosamine- and 2-Acetylaminofluorene-induced Hepatocarcinogenesis in Rats. Chinese Journal of Integrative Medicine. 2017 Feb;23(2):117-124.   SCI=1.978 (Integrative & Complementary Medicine 62.1%)
  45. Yun-Fei Ko, Jian-Ching Liau, Chien-Sheng Lee, Chen-Yaw Chiu, Jan Martel, Chuan-Sheng Lin, Shun-Fu Tseng, David M. Ojcius, Chia-Chen Lu, Hsin-Chih Lai, John D. Young*. Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body. PLoS One. 2017 Jan 3;12(1): e0168734. SCI=3.24 (Multidisciplinary Sciences 35.6%)
  46. Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tsung-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel, David M. Ojcius, Hsin-Chih Lai* & John D. Young*. An iron detection system determines bacterial swarming initiation and biofilm formation. Scientific Reports. 2016 Nov 15; 6:36747. SCI=4.379 (Multidisciplinary Sciences 23.29%)
  47. Hsin-Chih Lai, Yu-Tze Horng, Pen-Fang Yeh, Jann-Yuan Wang, Chin-Chung Shu,Chia-Chen Lu, Jang-Jih Lu, Jen-Jyh Lee and Po-Chi Soo*. The assessment of host and bacterial proteins in sputum from active pulmonary tuberculosis. Journal of Microbiology. 2016 Nov;54(11):761-767. SCI=3.422 (Microbiology  52.55%)
  48. Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M. Ojcius, Yun-Fei Ko, Hsin-Chih Lai* and John D. Young*. Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity. Innate Immunity. 2016 Oct;22(7):522-33. SCI=2.68 (Medicine, Research & Experimental 68.57%)
  49. Hwai-Jeng Lin, Fang-Yu Hsu, Wei-Wei Chen, Che-Hsin Lee, Ying-Ju Lin, Yi-Ywan M. Chen, Chih-Jung Chen, Mei-Zi Huang, Min-Chuan Kao, Yu-An Chen, Hsin-Chih Lai and Chih-Ho Lai*. Helicobacter pylori Activates HMGB1 Expression and Recruits RAGE into Lipid Rafts to Promote Inflammation in Gastric Epithelial Cells. Frontiers in Immunology. 2016 Sep 9;7:341. SCI=7.561   (Immunology 27.2%)
  50. Chia-Hao Lin, Chih-Yu Chi, Han-Po Shih, Jing-Ya Ding, Chia-Chi Lo, Shang-Yu Wang,Chen-Yen Kuo, Chun-Fu Yeh, Kun-Hua Tu, Shou-Hsuan Liu, Hung-Kai Chen, Chen-Hsuan Ho, Mao-Wang Ho, Chen-Hsiang Lee, Hsin-Chih Lai & Cheng-Lung Ku*. Identification of a major epitope by anti-interferon-γ autoantibodies in patients with mycobacterial disease. Nature Medicine. 2016 Sep;22(9):994-1001. SCI=53.44 (Medicine, Research & Experimental 0.7%)
  51. JanMartel, Hsin-ChihLai, Yun-FeiKo, John D.Young, David M.Ojcius* lternative functions for the multifarious inflammasome. Biomedical Journal. 2016 Jun;39(3):183-7. SCI=4.91 (Biochemistry & Molecular Biology 31.99%)
  52. Chuan-Sheng Lin, Chih-Jung Chang, Jan Martel, David M. Ojcius, Wei-Fan Lai, Chia-Chen Lu, Yun-Fei Ko, Hsin-Chih Lai*, John D. Young. Lipopolysaccharide: friend or foe? J Biomed Lab Sci 2016 Vol 28 No 4
  53. Patricia T. Santana, Jan Martel, Hsin-Chih Lai, Jean-Luc Perfettini*, Jean M. Kanellopoulos, John D. Young, Robson Coutinho-Silva, David M. Ojcius*. Is the inflammasome relevant for epithelial cell function?    Microbes and Infection. 2016 Feb;18(2):93-101. SCI=2.7 (Infectious Diseases 50.56%)
  54. Briliant Adhi Prabowo, Li-Chen Su, Ying-Feng Chang, Hsin-Chih Lai*, Nan-Fu Chiu, Kou-Chen Liu*. Performance of white organic light-emitting diode for portable optical biosensor. Sensors and Actuators B-Chemical. 2016 January; 222:1058-1065. SCI=7.46 (Instruments & Instrumentation 4.68%)
  55. Tsung-Teng Huang, Hsin-Chih Lai, Yun-Fei Ko, David M. Ojcius, Ying-Wei Lan, Jan Martel, John D. Young *& Kowit-Yu Chong*. Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo. Scientific Reports. 2015 Oct 26;5:15282. SCI=4.379 (Multidisciplinary Sciences 23.29%)
  56. Agnes Purwidyantri, Hsin-Chih Lai, Sheng-Hui Tsai, Ji-Dung Luo, Chiuan-Chian Chiou, Ya-Chung Tian, Chi-Hui Cheng, Yi-Ting Lin, Chao-Sung Lai*. Sensing performance of fibronectin-functionalized Au-EGFET on the detection of S. epidermidis biofilm and 16S rRNA of infection-related bacteria in peritoneal dialysis. Sensors and Actuators B. 2015 Oct 1;217: 92-99. SCI=7.46 (Instruments & Instrumentation 4.68%)
  57. Sheng-Hui Tsai, Hsin-Chih Lai, Shiau-Ting Hu. Subinhibitory Doses of Aminoglycoside Antibiotics Induce Changes in the Phenotype of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy. 2015 Oct; 59(10):6161-9. SCI=5.191  (Pharmacology & Pharmacy 12.64%)
  58. Chih-Jung Chang, Chuan-Sheng Lin, Chia-chen Lu, Jan Martel, Yun-Fei Ko, David M. Ojcius, Shun-Fu Tseng, Tung-Ru Wu, Yi-Yuan Margaret Chen, John D. Young*, Hsin-Chih Lai*. Ganoderma lucidum reduces obesitly in mice by modulating the composition of the gut microbiota. Nature Communications. 2015 Jun 23; 6:7489. SCI=14.919 (Multidisciplinary Sciences 8.45%)
  59. Chuan-Sheng Lin, Chih-Cheng Su, Shang-Chen Hsieh, Chia-Chen Lu, Tsu-Lan Wu, Ju-Hsin Jia, Ting-Shu Wu, Chau-Chung Han, Wen-Cherng Tsai, Jang-Jih Lu*, Hsin-Chih Lai*. Rapid identification of Mycobacterium avium clinical isolates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Microbiology, Immunology and Infection. 2015 Apr;48(2): 205-212. SCI=4.399    Microbiology 57.3%)
  60. Chin-Chung Shu, Jann-Yuan Wang, Chia-Lin Hsu, Li-Ta Keng, Kochung Tsui, Jeng-Feng Lin, Hsin-Chih Lai, Chong-Jen Yu*, Li-Na Lee, Kwen-Tay Lu. Diagnostic role of inflammatory and anti-inflammatory cytokines and effector molecules of cytotoxic T lymphocytes in tuberculous pleural effusion. Respirology. 2015 Jan;20(1): 147-54. SCI=6.424 (Respiratory System 17.5%)
  61. Tsai-Hsien Hung, Sheng-Chi Hsu, Ching-Yi Cheng, Kong-Bung Choo, Ching-Ping Tseng, Tse-Ching Chen, Ying-Wei Lan, Tsung-Teng Huang, Hsin-Chih Lai, Chuan-Mu Chen and Kowit-Yu Chong*. Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway. Oncotarget. 2014 Dec 15;5(23):12273-90. SCI=5.168 (Oncology 20.3%)
  62. Chia-Chen Lu, Ting-Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, John D. Young*, and Hsin-Chih Lai*. NK cells kill mycobacteria directly by releasing perforin and granulysin. Journal of Leukocyte Biology. 2014 Dec;96(6):1119-1129. SCI=4.962 (Hematology 26%)
  63. Jan Martel, David M. Ojcius, Hsin Chih Lai, John D. Young*. Mushrooms - From cuisine to clinic. Biomedical Journal. 2014 Nov-Dec;37(6): 343-344. SCI=4.91 (Biochemistry & Molecular Biology 66.4%)
  64. Tsung-Teng Huang, Hsin-Chih Lai*, Young-Bin Chen, Lih-Geeng Chen, Yi-Hui Wu, Yun-Fei Ko, Chia-Chen Lu, Chih-Jung Chang, Cheng-Yeu Wu, Jan Martel, David M Ojcius, Kowit-Yu Chong, John D Young. cis-Resveratrol produces anti-inflammatory effects by inhibiting canonical and non-canonical inflammasomes in macrophages. Innate Immun. 2014 Oct;20(7): 735-50. SCI=2.68 (Medicine, Research & Experimental 62.5%)
  65. Impact of the Gut Microbiota, Prebiotics, and Probiotics on Human Health and Disease. Biomedical Journal. 2014 Sep-Oct;37(5): 259-68. SCI=4.91 (Biochemistry & Molecular Biology 66.4%)
  66. Nan-Fu Chiu*, Teng-Yi Huang, Hsin-Chih Lai and Kou-Chen Liu. Graphene oxide-based SPR biosensor chip for immunoassay applications. Nanoscale Research Letters. 2014 Aug 28;9(1): 445. SCI=3.159 (Physics, Applied 27.7%)
  67. Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius, Yi-Hui Wu, Yun-Fei Ko, Cheng-Yeu Wu, Jan Martel, Chia-Chen Lu, Hsin-Chih Lai* & John D. Young*. The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome. Journal of Ethnopharmacology. 2014 Aug 8;155(1):154-64. SCI=4.36 (Plant Sciences 13.19%)
  68. Chun-Hung Yang, Hui-Ling Wang , Yi-Sheng Lin , K. P. Shravan Kumar, Hung-Chi Lin, Chih-Jung Chang, Chia-Chen Lu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, Yu-Sun Chang, John D. Young* , Hsin-Chih Lai*. Identification of CD24 as a Cancer Stem Cell Marker in Human Nasopharyngeal Carcinoma. PLoS One. 2014 Jun 23;9(6): e99412. SCI=3.24 (Multidisciplinary Sciences 35.6%)
  69. Briliant Adhi Prabowo, Ying-Feng Chang,Yu-Ying Lee, Li-Chen Su, Chih-Jen Yu, Yen-Heng Lin, Chien Chou, Nan-Fu Chiu, Hsin-Chih Lai*, Kou-Chen Liu*. Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor. Sensors and Actuators B Chemical . 2014 July 31; 198: 424-430. SCI=7.46 (Instruments & Instrumentation 4.68%)
  70. Po-Chi Soo, Yu-Tze Horng, Yung-Lin Chang, Wei-Wen Tsai, Wen-Yih Jeng, Chia-Chen Lu*, Hsin-Chih Lai*. ManA is regulated by RssAB signaling and promotes motility in Serratia marcescens. Research in Microbiology. 2014 Jan;165(1): 21-29. SCI=2.651 (Microbiology 57.1%)
  71. Chih-Jung Chang, Yi-Yuan M Chen, Chia-Chen Lu, Chuan-Sheng Lin, Jan Martel, Sheng-Hui Tsai, Yun-Fei Ko, Tsung-Teng Huang, David M Ojcius, John D Young, Hsin-Chih Lai*. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun. 2014 Apr;20(3): 301-311. SCI=2.173 (Medicine, Research & Experimental 62.5%)
  72. Chin-Chung Shu, Manabu Ato, Jann-Tay Wang, Ruwen Jou, Jann-Yuan Wang*, Kazuo Kobayashi*, Hsin-Chih Lai, Chong-Jen Yu, Li-Na Lee, Kwen-Tay Luh. Sero-Diagnosis of Mycobacterium avium Complex LungDisease Using Serum Immunoglobulin A Antibodyagainst Glycopeptidolipid Antigen in Taiwan. PLoS One. 2013 Nov 18;8(11): e80473. SCI=3.24 (Multidisciplinary Sciences 35.6%)
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