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Err-Cheng Chan

 

Err-Cheng Chan
chan

Highest Degree

Ph. D. in Biotechnology 

Purdue University

Areas of Specialty

Biotechnology, Medical Instrumentation

Office Phone

5220

Lab phone

5220

Research website

MEDICAL BIOTECHNOLOGY LABORATORY

E-mail

chanec@mail.cgu.edu.tw

Lab & Research Interest

Research interests

1. Mycobacterium tuberculosis Study: Tuberculosis is an infectious disease that causes three million people death worldwide annually. Our interest is to study pathogenic mechanism of Mycobacterium tuberculosis and to develop detection method of this bacterium. The effect of M. tuberculosis on signal transduction and gene expression in WI-38 cell line will be studied. In addition, a reliable, noninvasive, and simple diagnostic method will be developed. 

2. Study of Tumor Biomarkers: By using proteomic technques to study tumor markers of the colorectal cancer and lung cancer, and to develop their diagnostic kits. We also develop the immuno-diagnostic kits for the Chang Gung Hospital “in house” use.

3. Chronic obstructive pulmonary disease (COPD) refers to chronic bronchitis and emphysema, a pair of two commonly co-existing diseases of the lungs. Our interest is to study pathogenic mechanism of COPD and autoantibody response in COPD patients. The association between the levels of anti-elastin autoantibodies and COPD pathogenesis will be studied.

Publication

  1. Chou YC, Lee D, Chang TM, Hsu YH, Yu YH, Chan EC, Liu SJ. Combination of a biodegradable three-dimensional (3D) - printed cage for mechanical support and nanofibrous membranes for sustainable release of antimicrobial agents for treating the femoral metaphyseal comminuted fracture. J Mech Behav Biomed Mater. 2017 Aug;72:209-218.

  2. Fan CW, Kuo YB, Lin GP, Chen SM, Chang SH, Li BA, Chan EC. Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer. Clin Chim Acta. 2017 Dec;475:157-163.

  3. Wu RS, Hong JJ, Wu JF, Yan S, Wu D, Liu N, Liu QF, Wu QW, Xie YY, Liu YJ, Zheng ZZ, Chan EC, Zhang ZM, Li BA. OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis. Oncotarget. 2017 Jun 13;8(24):39401-39416.

  4. Hsu YH, Lin CT, Yu YH, Chou YC, Liu SJ, Chan EC. Dual delivery of active antibactericidal agents and bone morphogenetic protein at sustainable high concentrations using biodegradable sheath-core-structured drug-eluting nanofibers. Int J Nanomedicine. 2016 Aug 17;11:3927-37.

  5. Lu YC, Chang JT, Chan EC, Chao YK, Yeh TS, Chen JS, Cheng AJ. miR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers. J Cancer. 2016 Mar 20;7(6):650-5.

  6. Chang PY, Chen JS, Chang NC, Chang SC, Wang MC, Tsai SH, Wen YH, Tsai WS, Chan EC2,3, Lu JJ. NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing. Oncotarget. 2016 Jun 21;7(25):37566-37580.

  7. Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA. OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors. Gastroenterology. 2016 Mar;150(3):659-671.

  8. Chang PY, Chen CC, Chang YS, Tsai WS, You JF, Lin GP, Chen TW, Chen JS, Chan EC. MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection. Oncotarget. 2016 Mar 1;7(9):10663-75.

  9. Kuo YB, Li YS, Chan EC. Rapid identification of HPV 16 and 18 by multiplex nested PCR-immunochromatographic test. J Virol Methods. 2015 Feb;212:8-11.

  10. Chen CY, Chen JS, Chou YP, Kuo YB, Fan CW, Chan EC. Antibody against N-terminal domain of phospholipid scramblase 1 induces apoptosis in colorectal cancer cells through the intrinsic apoptotic pathway. Chem Biol Drug Des. 2014 Jul;84(1):36-43.

  11. Kuo YB, Chen JS, Fan CW, Li YS, Chan EC. Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer. Clin Chim Acta. 2014 Jun 10;433:284-9.

  12. Chang PY, Kuo YB, Wu TL, Liao CT, Sun YC, Yen TC, Chan EC. Association and prognostic value of serum inflammation markers in patients with leukoplakia and oral cavity cancer. Clin Chem Lab Med. 2013 Jun;51(6):1291-300.

  13. Kuo YB, Chao M, Lee YH, Yeh CT, Chan EC. New enzyme-linked immunosorbent assay for detection of antibodies against hepatitis delta virus using a hepatitis delta antigen derived from a Taiwanese clone and comparison to the Abbott radioimmunoassay. Clin Vaccine Immunol. 2012 May;19(5):817-9.