黃幸宜 助理教授
Hsing-I
Huang, Ph. D
Contact information
第一醫學大樓十二樓新興病毒感染研究中心
TEL:
(03)211-8800 ext. 3721
E-mail: hihuang@mail.cgu.edu.tw
Education
Ph. D. Graduate Program in Microbiology and
Molecular Genetics,
Rutgers
University, The State University of New Jersey, New Brunswick, New Jersey, U.S.A.
B.S. Department of Medical
Technology,
Professional Experiences
2008-2009 Adjunct
assistant professor,
2004-2009 Adjunct
assistant professor,
2002-2009 Chief,
Tumor Immunology Lab., Cathay Medical Research Institute,
2000-2002 Postdoctoral
fellow,
Academia
Specialties
Cell
Biology, Cancer Biology, Immunology
Memberships
International
Society for Stem Cell Research (ISSCR)
Taiwan
Society for Stem Cell Research (台灣幹細胞學會)
Research Interests
本研究室的研究方向包括：
(一) 研究幹細胞在組織工程方面的應用
幹細胞由於其自我更新分化為其它體細胞能力，因此能應用於再生醫學上以修補受損的器官或組織。而成體幹細胞由於沒有一般胚胎幹細胞的缺點如免疫排斥，腫瘤生成以及道德爭議，因此在醫療應用上更具潛力。研究發現不同種類的成體幹細胞具有不同的分化能力，因此我們希望可以將合適的幹細胞應用於特定的組織再生醫學應用上，此外亦會合併基因轉殖、RNAi等技術以發展更有效的方法。
(二) 探討病毒與宿主幹細胞之間的關係
幹細胞極容易被各種因素影響，包括化學藥劑，生長激素，表面分子等，甚至物理因素也能夠左右其分化路徑。然而目前我們對於生物因素，例如細菌或病毒感染是否能影響幹細胞的特性則較不了解。有一些研究指出病毒的感染能使得某些成體幹細胞分化為特定的體細胞，但是對於其它幹細胞特性的影響之研究則較為缺乏。因此，我們研究室目前致力於研究病毒感染對於幹細胞的影響。尤其針對一些新興病毒，是否能經由感染幹細胞而影響其致病機轉是我們相當有興趣的一個研究方向。
Expert Reviewer
Journal
of Cellular and Molecular Medicine
Tissue
Engineering
American
Journal of Hematology
Journal
of Cell Biology
Acta
Pharmalogica Sinica
Cell
Proliferation
Publications
Journal Papers
Wang
RY, Kuo RL, Ma WC, Huang HI,
Yu JS, Yen SM, Huang CR, Shih SR. Heat shock protein-90-beta facilitates
enterovirus 71 viral particles assembly. Virology.
2013 Sep 1;443(2):236-47. (SCI; IF: 3.367)
Chen
CC, Huang HI, Louis CL, Lin
KT, Ron Y. Isolation of multilineage progenitors from mouse brain. In Vitro
Cell Dev Biol Anim. 2013 May;49(5):307-14. (co-first author) (SCI; IF: 1.312)
Hsing-I
Huang, Kuo-Feng Weng, Shin-Ru Shih. Viral and host
factors that contribute to pathogenicity of enterovirus 71. Future Microbiol. 2012
Apr;7(4):467-79. (SCI; IF: 4.018)
Shih-Hsin Tu*, Hsing-I Huang*, Su-I Lin, Hsin-Yu Liu, Yuh-Pyng Sher,
Sheng-Kuo Chiang, Pele Chong, Steve Roffler, Hsin-Wei Chen, Shih-Jen Liu. A
novel HLA-A2-restricted CTL epitopes of tumor associated antigen L6 could
inhibit tumor growth in vivo. J Immunother. (co-first author)(SCI; IF: 3.463)
Huang PN, Lin JY, Locker N, Kung YA,
Huang
HI*,
Tissue Eng Part A. 2010 May;16(5):1491-501. (Corresponding author)
(SCI; IF: 4.409)
Chung
CA, Lin TH, Chen SD, Huang HI.
Hybrid cellular automaton modeling of nutrient modulated cell growth in tissue
engineering constructs. J Theor Biol. 2010 Jan 21;262(2):267-78.
(SCI; IF: 2.496)
Yen BL, Chien CC, Chen
YC, JT Chen, Huang JS, Lee FK, Huang
HI*. Placenta-derived multipotent cells differentiate into neuronal and
glial cells in vitro. Tissue
Engineering 2008 Jan;14(1):9-17. (Corresponding
author) (SCI; IF: 4.409)
Yen
ML, Chien CC, Chiu IM, Huang HI,
Chen YC, Hu HI, Yen BL. Multilineage differentiation and characterization of
the human fetal osteoblastic 1.19 cell line: a possible in vitro model of human
mesenchymal progenitors.
Stem
Cells. 2007,
25(1):125-31. (SCI;
IF: 7.701)
Chien CC, Fu WH, Huang HI, Lai YH, Tsai YF, Guo SL, Wu TJ, Ling QD. Expression of
Neurotrophic Factors in Neonatal Rats After Peripheral Inflammation. J Pain. J Pain. 2007;8(2):161-7. (SCI; F:
3.578, Clinical Neurology :18.9%)
Chang CJ, Yen ML, Chen YC, Chien CC, Huang HI, Bai CH, Yen BL. Placenta-derived
multipotent cells exhibit immunosuppressive properties that are enhanced in the
presence of interferon-gamma. Stem
Cells. 2006, 24(11):2466-77.
(SCI; IF: 7.701)
Chien
CC, Yen BL, Lee FK, Lai TH, Chen YC, Chan SH, Huang HI*. In vitro differentiation of human
placenta-derived multipotent cells into hepatocyte-like cells. Stem Cells. 2006, 24(7): 1759~1768. (Corresponding author) (SCI; IF: 7.701)
Yen BL, Huang HI, Chih-Cheng Chien, Hsiang-Yiang Jui, Ming
Huang
HI,
Wu PY, Teo CY, Chen MN, Chen YC, Silin D, Tao MH. Improved
immunogenicity of a self tumor antigen by covalent linkage to CD40 ligand. Int. J Cancer. 2004, 108(5):696-703. (SCI; IF: 6.198)
Huang
HI, Chien CC, Tu SH, Sung YC, Lin CL, and Chen KM. The expression of MAGE genes in human breast carcinoma in
Shih-Hsin Tu, Hsing-I Huang, Chin-Long Lin, Jaan-Yeh Jeng,
Feng-Chun Tsi, Kai-Mo Chen. Expression
of MAGE-6 and NY-ESO-1 Genes in Breast Cancer among Taiwanese Women. Fu-Jen
J. of Medicine, 2004, 2(suppl):s189-s196. (contributed
equally)
Chen HW, Huang HI, Lee YP, Chen LL, Liu HK, Cheng ML, Tsai JP, Tao MH, Ting CC. 2002, Aug. Linkage of CD40to a self-tumor antigen enhances the antitumor immune responses of dendritic cell based treatment. Cancer Immunol Immunother. 51(6):341-8. (SCI; IF:3.637)
Huang TH, Wu PY, Lee CN, Huang
HI, Hsieh SL, Kung J, Tao MH. 2000, Dec.
Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen. Blood 96(12):3663-70. (SCI; IF: 9.06)
Chan MM, Huang HI, Fenton MR, Fong D. 1998, Jun, In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol. 55(12):1955-62. (SCI; IF:4.529)
Chan MM, Fong D, Ho CT, Haung HI. 1997, Dec, Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea. Biochem Pharmacol. 55(12):1281-6. (SCI) (SCI; IF:4.529)
Chan MM, Ho CT, Huang HI. 1995,
Effects of three dietary phytochemicals
from tea, rosemary and turmeric on inflammation-induced nitrite production.
Cancer Lett. 4;96(1):23-9.
(SCI) (IF: 3.398)
ABSTRACTS
Hsin-Hsu
Chen and Hsing-I Huang. The
Effects of Enterovirus 71 Infection on Mouse Neural Stem Cells. International
symposium on RNA Viruses 2011.
Hsing-I
Huang＊,
Shu-Hui Chan, Tsung-Ru Wu, Jen-Der Song. Comaparative characterization of
multipotent cells isolated from human amniotic membrane and placenta. ISSCR 9th Annual Meeting,
The
molecular mechanism of enterovirus 71 infection in the neuronal progenitor
cells.
Lin JY, Chan SH, Su LC, Huang HI,
Shih SR. International symposium of RNA Viruses 2010.
Hsing-I Huang＊, CC Cheng, SK Chen,
Hsiao-Tun Liu. The comparison of human FDSC and PDMCs in their in
vitro hepatic differentiation abilities. ISSCR 8th Annual Meeting,
In
Vitro Hepatic Differentiation of Multipotent Cells
Derived from Human Placenta and Umbilical Cord. Hsing-I
Huang, Tsung-Hsuan Lai, B Linju Yen, Yao-Chang Chen,
Shu-Hui Chan, Chih-Cheng Chien. 5th ISSCR Symposium,
Expression of hepatocyte-like phenotypes in human
placenta-derived multipotent cells after HGF and FGF-4 induction. Hsing-I Huang, Tsung-Hsuan Lai,
Fa-Kung Lee, B Linju Yen, Yao-Chang Chen, Shu-Hui
Chan, Chih-Cheng Chien.
國際幹細胞研討會, Taipei, Taiwan, 2006.
Differential Maturation of Human Monocyte-derived
Dendritic Cells by Lipopolysaccharide and poly I:C.
Li-Chiu Su , and Hsing-I Huang*.台灣分子醫學研討會Taipei,
Isolation of Multipotent Progenitors from Human Term
Umbilical Cord. Shu-Hui Chan, Tsung-Hsuan Lai and Hsing-I Huang*.台灣分子醫學研討會Taipei, Taiwan, 2006.
BOOKS
Isolation
and Differentiation Potential of Fibroblast-Like Stromal Cells Derived from
Human Skin. Hsing-I
Huang* and Chung-Zu Wu. Somatic Stem Cells: Protocol for Methods
in Molecular Biology (2011), Humana/Springer press
Huang HI*. Isolation
of Placenta-Derived Multipotent Cells from Human Placenta and In Vitro
Differentiation into Hepatocyte-Like Cells. Current Protocols in Stem Cell Biology. Unit 1H.1, Wiley Interscience.
Chan
MM, Huang HI, Mattiacci JA,
Fong D. 2002, Jul, Modulation of cytokine gene expression by curcumin. In “Food factors for disease prevention
and health promotion” edited by Shahidi F,
2012 實驗室成員和大學專題生們
2013 Aug實驗室迎新送舊