Hung-Yao Ho

Highest Degree

Ph. D. in National Defense Medical Center Graduate Institutes of Life  Sciences, Taiwan

Areas of Specialty

Tissue Engineering; Stem Cell Research; Gerontological Research; Redox  Biology

Office Phone

3318

Lab phone

5998

Research website

Redox Biology and Redoxomics Research Laboratory

E-mail

hoh01@mail.cgu.edu.tw

Lab & Research Interest

1. To study the relationship between oxidative stress and infectious diseases

Variations in cellular microenvironment affect the susceptibility of host cells to pathogens. The roles of certain host factors such as redox status remain elusive. Recently, we have shown that the replication and cytopathogenicity of enterovirus are greatly enhanced when the cellular redox balance is tilted toward an oxidizing end. The mitochondrial function is altered during infection. We aim to study the underlying molecular mechanisms using molecular technologies, animal models and proteomic profiling. We found that antioxidant treatment deters viral infection. Herbal extract with antioxidant capacity alleviates the virulence and pathogenicity of virus and clinical outcome of infection.

2. To study how mitochondrial defect and oxidative stress affect tumorigenesis

Mitochondrion is a powerhouse, a major source of reactive oxygen species, as well as a regulator of cellular processes such as apoptosis. It is conceivable that mitochondrial dysfunction may play a role in cellular transformation and tumorigenesis. We have shown that alteration in mitochondrial functions and redox environment change the growth of tumor cells. This is our aim to study the mechanistic aspects using molecular technologies, animal models, transcriptomic and metabolomic profiling.

3. Study of metabolic signaling inβ cells and its roles in pathogenicity of type 2 diabetes

Pancreatic β cells secrete insulin and play an essential role in maintaining blood glucose level. Nutrient detection and insulin secretion by β cells depend on active metabolism in a process known as metabolism-secretion coupling. Metabolites are involved in regulation of these metabolic pathways, and activities of signaling proteins and exocytotic proteins. Any anomalies of such metabolic signaling may cause dysfunction In insulin secretion. It is believed that dysregulation of insulin secretion and β cell functions play important roles in pathogenesis of type 2 diabetes. Using molecular techniques, animal models omic technologies, we study the metabolic signaling in β cells and pathogenesis of type 2 diabetes.

Publication

1. Chen SG, Leu YL, Cheng ML, Ting SC, Liu CC, Wang SD, Yang CH, Hung CY, Sakurai H, Chen KH, Ho HY. Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific Reports.2017; 7(1):12264. (SCI)
2. Ho HY, Lin YT, Lin G, Wu PR, Cheng ML. Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation. Redox Biology. 2017;12:916-928. (SCI)
3. Tang HY, Ho HY, Chiu DT, Huang CY, Cheng ML, Chen CM. Alterations of plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre syndrome. Clinica Chimica Acta. 2017; 470:75-80. (SCI)
4. Chen SG, Cheng ML, Chen KH, Horng JT, Liu CC, Wang SM, Sakurai H, Leu YL, Wang SD, Ho HY. Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo. Scientific Reports. 2017; 7(1):935. (SCI)
5. Tang HY, Wang CH, Ho HY, Wu PT, Hung CL, Huang CY, Wu PR, Yeh YH, Cheng ML. Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. Redox Biology.2017;14:499-508. (SCI)
6. Cheng ML, Chi LM, Wu PR, Ho HY. Dehydroepiandrosterone-induced changes in mitochondrial proteins contribute to phenotypic alterations in hepatoma cells. Biochemical Pharmacology.2016;117:20-34. (SCI)
7. Wu YH, Chiu DT, Lin HR, Tang HY, Cheng ML, Ho HY. Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. Viruses. 2016;7:6689-6706. (SCI)
8. Cai N, Chang S, Li Y, Li Q, Hu J, Liang J, Song L, Kretzschmar W, Gan X, Nicod J, Rivera M, Deng H, Du B, Li K, Sang W, Gao J, Gao S, Ha B, Ho HY, Hu C, Hu J, Hu Z, Huang G, Jiang G, Jiang T, Jin W, Li G, Li K, Li Y, Li Y, Li Y, Lin YT, Liu L, Liu T, Liu Y, Liu Y, Lu Y, Lv L, Meng H, Qian P, Sang H, Shen J, Shi J, Sun J, Tao M, Wang G, Wang G, Wang J, Wang L, Wang X, Wang X, Yang H, Yang L, Yin Y, Zhang J, Zhang K, Sun N, Zhang W, Zhang X, Zhang Z, Zhong H, Breen G, Wang J, Marchini J, Chen Y, Xu Q, Xu X, Mott R, Huang G J, Kendler K, Flint J. Molecular signatures of major depression. Current Biology.2015; 25(9):1146-1156. (SCI)
9. Cheng ML, Wang CH, Shiao MS, Liu MH, Huang YY, Huang CY, Mao CT, Lin JF, Ho HY, Yang NI. Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure Diagnostic and Prognostic Value of Metabolomics. Journal of The American College of Cardiology.2015; 65:1509-1520. (SCI)
10. Yang HC, Cheng ML, Hua YS, Wu YH, Lin HR, Liu HY, Ho HY, Chiu DTY. Glucose 6-phosphate dehydrogenase knockdown enhances IL-8 expression in HepG2 cells via oxidative stress and NF-κB signaling pathway. Journal of Inflammation-London.2015;12:34. (SCI)
11. Tang HY, Ho HY, Wu PW, Chen SH, Kuypers FA, Cheng ML, Chiu DTY. Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance. Antioxidants & Redox Signaling.2015; 22:744-759. (SCI)
12. Cheng ML, Weng SF, Kuo CH, Ho HY. Enterovirus 71 induces mitochondrial reactive oxygen species generation that is required for efficient replication. PLoS ONE .2014; 9 (11): e113234. (SCI)
13. Ho HY , Cheng ML, Chiu DTY. Glucose-6-phosphate dehydrogenase – beyond the realm of red cell biology. Free Radical Research. 2014; 48:1028-1048. (SCI)
14. Hsieh YT, Lin MH, Ho HY, Chen LC, Chen CC, Shu JC. Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Epithelial Cells Are Less Tolerant to Infection by Staphylococcus aureus. PLoS One.2013; 8(11):e79566. (SCI)
15. Cheng ML, Ho HY, Lin HY, Lai YC, Chiu DTY. Effective NET Formation in Neutrophils from Individuals with G6PD Taiwan-Hakka is Associated with Enhanced NADP⁺ Biosynthesis. Free Radical Research.2013; 47:699-709. (SCI)
16. Yang HC, Chen TL, Wu YH, Cheng KP, Lin Y H, Cheng ML, Ho HY, Lo SJ, Chiu DTY. Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death & Disease.2013; 4:e616. (SCI)
17. Ho HY, Cheng ML, Shiao MS, Chiu DTY. Characterization of Global Metabolic Responses of G6PD-Deficient Hepatoma Cells to Diamide-Induced Oxidative Stress. Free Radical Biology & Medicine.2013; 54:71-84. (SCI)