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Rei-Lin Kuo

Rei-Lin Kuo

rei-lin kuo

Highest Degree

Ph. D. in Institute of Microbiology and Immunology, National  Yang-Ming  University, Taiwan

Areas of Specialty

Molecular virology; Virus and host interaction

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Lab & Research Interest

1. The induction of the IFN expression is a critical event for innate immunity to disrupt viral replication in virus-infected cells. It has been demonstrated that viruses can evade host innate immunity by targeting the pathway for type I IFN activation. The regulation of the type I IFN production has been considered an important factor for virus pathogenicity. Since enteroviruses are important human pathogens that periodically causes several outbreaks with severe neurological complications in recent years, our lab is endeavoring to elucidate the mechanism for the regulation of signaling pathway for type I IFN production in enterovirus-infected cells. The understanding of the regulation of IFN production may provide the information for enterovirus pathogenicity and the basis for the development of new antiviral drugs.      

 2. The viral RNA synthesis is directly involved in the virus replication during influenza A virus infection. Base on pathogenicity studies, the viral polymerase has been considered as one of the contributors for the virulence of influenza viruses. Our lab is interested in verifying the polymerase activities of highly pathogenic influenza virus strains by several systems. In addition, influenza viral proteins interact with many host proteins. We are also investigating the impacts of the interactions in pathogenicity during influenza virus infection.


Selected publications (since 2016)

1. Rei-Lin Kuo*, Yi-Tung Chen, Huai-An Li, Chih-Ching Wu, Hsiao-Chu Chiang, Jhao-Yin Lin, Hsing-I Huang, Shin-Ru Shih, Bertrand Chin-Ming Tan*. Molecular determinants and heterogeneity underlying host response to EV-A71 infection at single-cell resolution. 2021. RNA Biology, 18(5), 796-808. (*co-corresponding author)

2. Yen-Chin Liu*, Rei-Lin Kuo*, Shin-Ru Shih. COVID-19: The first documented coronavirus pandemic in history. 2020. Biomedical Journal, 43(4), 328-333. (*equal contribution)

3. Kuo-Ming Lee, Chih-Ching Wu, Shang-En Wu, Ya-Han Lin, Li-Ting Wang, Chun- Ru Chang, Peng-Nien Huang, Shin-Ru Shih, and Rei-Lin Kuo*. The RNA-dependent RNA polymerase of enterovirus A71 associates with ribosomal proteins and positively regulates protein translation. 2020. RNA Biology, 17(4), 608-622. (*corresponding author)

4. Jhao-Yin Lin, Rei-Lin Kuo, and Hsing-I Huang. Activation of type I interferon antiviral response in human neural stem cells. 2019. Stem Cell Research & Therapy, 10:387

5. Rei-Lin Kuo*, Chi-Jene Chen, Robert YL. Wang, Hsing-I Huang, Ya-Han Lin, Ee-Hong Tam, Wen-Jung Tu, Shang-En Wu, Shin-Ru Shih. Role of enteroviral RNA-dependent RNA polymerase in regulation of MDA5-mediated beta interferon activation. 2019. Journal of Virology, 93(10), e00132-19. (*corresponding author)

6. Yu-Nong Gong*, Rei-Lin Kuo*, Guang-Wu Chen, Shin-Ru Shih. Centennial review of influenza in Taiwan. 2018. Biomedical Journal, 41:234-241. (*equal contribution)

7. Rei-Lin Kuo, Chi-Jene Chen, Ee-Hong Tam, Chung-Guei Huang, Li-Hsin Li, Zong-Hua Li, Pei-Chia Su, Hao-Ping Liu, and Chih-Ching Wu. Interactome analysis of NS1 protein encoded by influenza A H7N9 virus reveals an inhibitory role of NS1 in host mRNA maturation. 2018. Journal of Proteome Research, 17: 1474-1484.

8. Cheng-Kai Chang, Chi-Jene Chen, Chih-Ching Wu, Shiau-Wen Chen, Shin-Ru Shih*, and Rei-Lin Kuo*. Cellular hnRNP A2/B1 interacts with the NP of influenza A virus and impacts viral replication. 2017. PLoS ONE, 12(11):e0188214. (*co-corresponding author)

9. Rei-Lin Kuo*, Zong-Hua Li, Li-Hsin Li, Kuo-Ming Lee, Ee-Hong Tam, Helene M. Liu, Hao-Ping Liu, Shin-Ru Shih, and Chih-Ching Wu*. Interactome analysis of the NS1 protein Encoded by influenza A H1N1 virus reveals a positive regulatory role of host protein PRP19 in viral replication. 2016. Journal of Proteome Research, 15: 1639-1648. (*co-corresponding author)

10. Rei-Lin Kuo,* Li-Hsin Li, Sue-Jane Lin, Zong-Hua Li, Guang-Wu Chen, Cheng-Kai Chang, Yi-Ren Wang, Ee-Hong Tam, Yu-Nong Gong, Robert M. Krug,* and Shin-Ru Shih. Role of N terminus truncated NS1 proteins of influenza A virus in inhibiting IRF3 activation. 2016. Journal of Virology, 90(9): 4696-4705. (*co-corresponding author)

11. Kin Fong Lei,* Chia-Hao Huang, Rei-Lin Kuo,* Cheng-Kai Chang, Kuan-Fu Chenf, Kuo-Chien Tsao, and Ngan-Ming Tsang. Paper-based enzyme-free immunoassay for rapid detection and subtyping of influenza A H1N1 and H3N2 viruses. 2015. Analytica Chimica Acta, 883:37–44. (*co-corresponding author)

12. Rei-Lin Kuo,* Ya-Han Lin, Robert Yung-Liang Wang, Chia-Wei Hsu, Yi-Ting Chiu, Hsing-I Huang, Li-Ting Kao, Jau-Song Yu, Shin-Ru Shih, and Chih-Ching Wu.* Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication. 2015. Journal of Proteome Research, 14:1818-1830. (*co-corresponding author)

Conference presentations (since 2016)

1. Kuo RL., Chen CJ., Lin YH, Tam EH., Tu WJ., Wu SE., Shih SR. Enteroviral RNA-dependent RNA polymerase interacts with MDA5 and is involved in regulation of interferon-b expression. Keystone symposia for 2019 conference on: Positive-strand RNA viruses. June 9-13, 2019, Killarney, Ireland.

2. Kuo RL., Tam EH., Chen CJ., Li ZH., Li LH., Su PC., and Wu CC. Systemic Identification of Host Proteins Interacting with Influenza A H7N9 NS1 protein Reveals Its Regulatory Role of NS1 in Host mRNA Maturation. American Society for Virology 37th Annual Meeting, July 14-18, 2018, College Park, Maryland, USA

3. Kuo RL., Li ZH., Li LH., Lee KM., Tam EH., Shih SR., and Wu CC. Systemic analysis of the host proteins that interact with the NS1 protein encoded by influenza A H1N1 virus by proteomic approach. American Society for Virology 36th Annual Meeting, June 24-28, 2017, Madison, Wisconsin, USA

4. Kuo, RL., Lin, YH., Wang, RYL., Yu, JS., Shih, SR., and Wu, CC. A proteome-wide dysregulation analysis identifies the involvement of NEDD4L and PSMF1 in EV71 replication. Keystone symposia for 2016 conference on: Positive-strand RNA viruses. May 1-5, 2016, Austin, Texas, USA