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Chia-Rui Shen


Highest Degree

Ph. D. in Immunology University of Bristol, UK

Areas of Specialty

Immunology, Clinical Chemistry, Clinical Serology

Office Phone

+886 3 2118800 ext 5200

Fax number:

+886 3 2118698

Research website:



Research and Professional Positions/Appointments:

Aug.2018 -            Chair, Department of Medical Biotechnology and Laboratory Science, Chang Gung University

Jan. 2016 -          Associate Researcher, Department of Ophthalmology, Linkou Chang Gung Memorial Hospital

Jul. 2013 -Sep. 2013 Visiting Scholar, Genomic and Proteomic Center, Academia Sinica

Aug. 2010 -              Associate Professor, Department of Medical Biotechnology and Laboratory Science, Chang Gung University

Dec. 2006 -Jan. 2007   Visiting Scholar, Department of Radiology, Washington University in St. Louis, USA

Feb.2000 - Jul.2010   Assistant Professor, Department of Medical Biotechnology and Laboratory Science, Chang University

Sep.1998 - Feb.2000   Postdoctoral fellow, Institute of Biomedical Science, Academia Sinica 

Aug. 1993 - Jul. 1994    Teaching Assistant, Department of Medical Technology, College of Medicine, National Cheng Kung University


  Ph.D.   1998     Department of Pathology and Microbiology, Faculty of Medicine, University of Bristol, United Kingdom

  B.Sc.   1993     Department of Medical Technology, College of Medicine, National Cheng Kung University


American Association for the Advancement of Science (AAAS)

American Chemical Society (ACS)

Biotechnology and Biochemical Engineering Society of Taiwan (BEST)

British Society of Immunology (BSI)

The Chinese Society of Immunology (Council member 2012-)

The Chinese Society of Cell and Molecular Biology (CSCMB)

The Federation of Clinical Immunology Societies (FOCIS)

The Taiwan Society of Laboratory Medicine

The Taiwan Society for Chitin and Chitosan (Council member 2008-)

The Society of Taiwan Women in Science and Technology (TWiST) 

Book and Book Chapter (in English):

Advances in Chitin Science- vol XII, p196-199. (2010) Published by FEQ-UNICAMP , Brazil (ISBN978-85-64131-00-2)

Elson, CJ, Shen, CR (1998) Anemia, autoimmune hemolytic in experimental model. In Encyclopedia of Immunology (p.91-93), 2nd Ed. Edited by Roitt, I.M. and Delves, P.J. Arnold.

USA Patents:

2015 A Chitin-induced Immune Response Based Method for Diagnosing Allergic Asthma in Patients. USA Patent US9,005,899.

2010 Development of asthma therapy with rAAV-mediated AMCase shRNA. USA Patent US 7,851,616. 


  1. Shen CR (correspondence), Juang JH, Tsai ZT, Wu ST, Tsai FY, Wang JJ, Yen TC. Preparation, characterization and application of superparamagnetic iron oxide encapsulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride. Carbohydr Polym 2011 Mar; 84(1): 781- 787. Epub 2010 Aug. SCI=4.811 (CHEMISTRY, APPLIED, 5.56%)
  2. Lee MH, Chang JT, Yu FW, Shen CR (correspondence). The prevalence of IL-17–producing cells in patients with Nasopharyngeal carcinoma. J Biomed Lab Sci 2011 Mar; 23(1): 30-37.
  3. Shen CR, Wu ST, Tsai ZT, Wang JJ, Yen TC, Tsai JS, Liu CL. Characterization of the Quaternized chitosan-stabilized iron-oxide nanoparticles as a novel potential MRI contrast agent for cell tracking. Poly International 2011 Jun 60(6): 945-950. SCI=2.070(POLYMER SCIENCE, 36.05%)
  4. Chen JK, Yeh CH, Wang LC, Liou TH, Shen CR (correspondence), Liu CL. Chitosan, the marine functional food for a potent adsorbent of humic acid. Mar Drugs 2011 9, 2488-2498. SCI=3.503 (CHEMISTRY, MEDICINAL, 21.67%)
  5. Tsai JP, Lee MH, Hsu SC, Chen MY, Liu SJ, Chang JT, Liao CT, Cheng AJ, Chong P, Shen CR (correspondence), Chen HW. CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions. J Immunol 2012 189:1671-1679 SCI=4.856 (IMMUNOLOGY, 22.52%)
  6. Tsai ZT, Tsai FJ, Yang WC, Wang JF, Liu CL, Shen CR (correspondence), Yen TC. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential MRI T2 contrast agent. Mar Drugs 2012; 10(11), 2403-2414. SCI=3.503 (CHEMISTRY, MEDICINAL, 21.67%)
  7. Hsu PH, Wei KC, Huang CY, Wen CJ, Yen TC, Liu CL, Lin YT, Chen JC, Shen CR (correspondence), Liu HL. Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound. PLoS One 2013 Feb; 8(2): e57682. SCI=2.806 (MULTIDISCIPLINARY SCIENCES, 23.44%)
  8. Shen CR, Liu CL, Lee HP, Chen JK. The identification and characterization of chitotriosidase activity in pancreatin from porcine pancreas. Molecules 2013 Mar; 148, 2978-2987. SCI=2.861 (CHEMISTRY, ORGANIC, 28.81%)
  9. Shen CR, Chen HW. Fatal attraction: tumor recruitment of myeloid-derived suppressor cells is mediated by IL-17-producing CD8+ T cells. Transl Gastrointest Cancer 2013 June; 2(S1):119-122. doi: 10.3978/j.issn.2224-4778.2013.05.25.
  10. Hwang YS, Chiang PR, Hong WH, Chiao CC, Chu IM, Hsiue GH, Shen CR (correspondence). Study in vivo intraocular biocompatibility of in situ gelation hydrogels: Poly (2-ethyl oxazoline)- block- poly (<epsilon>- caprolactone)- block- poly (2-ethyloxazoline) Copolymer, Matrigel and Pluronic F127. PLoS One 2013 July; (7): e67495. SCI=2.806 (MULTIDISCIPLINARY SCIENCES, 23.44%)
  11. Chen YS, Liu CL, Lee MH, Chen HW, Shen CR (correspondence). The role of Tc17 in cancer immunity and clinical associations. J Biomed Lab Sci 2013 Sep; 25(3): 77-83.
  12. Shen CR, Yang WC, Chen HW. The fate of regulatory T cells: survival or apoptosis. Cell Mol Immunol 2014 Jan; 11(1):11-13. doi:10.1038/cmi.2013.49. SCI=5.897 (IMMUNOLOGY, 17.22%)
  13. Chen YS, Shen CR (correspondence). Immune checkpoint blockade therapy: The 2014 Tang Prize in Biopharmaceutical Science. Biomed J 2015 38:5-8.
  14. Shen CR, Juang HH, Chen HS, Yang CJ, Wu CJ, Lee MH, Hwang YS, Kuo ML, Chen YS, Chen JK, Liu CL. The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma. Int J Mol Sci. 2015 Nov; 16(11): 27371-27377. SCI=3.226 (CHEMISTRY, MULTIDISCIPLINARY, 32.53%)
  15. Yang WC, Hwang YS, Chen YY, Liu CL, Shen CN, Hong WH, Lo SM, Shen CR (correspondence). Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells. Front Immunol 2017 Nov; 8: Article 1508. SCI=6.429 (IMMUNOLOGY, 13.91%)
  16. Lee MH, Chang TC, Liao CT, Chen YS, Kuo ML, Shen CR (correspondence). Interleukin 17 and Peripheral IL-17-Expressing T cells are Negatively Correlated with the Overall Survival of Head and Neck Cancer Patients. Oncotarget 2018 Jan; 9(11): 9825-9837. SCI=5.168 (ONCOLOGY, 20.28%).
  17. Yang WC, Hwang YS, Shen CR (correspondence) Interleukin-4. Encyclopedia of Life Sciences. 2018 (Accepted for publication)
  18. Chen YS, Huang TH, Liu CL, Chen HS, Lee MH, Chen HW, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther. 2018 Aug 4. doi: 10.1089/hum.2018.104. SCI=4.187 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 15.82%)